Open Access DOI:10.23937/2469-5831/1510009
Hierarchical Bayes Approach for Analysis of Item-Level Missing Data
Junshan Qiu and Ram Tiwari
Article Type: Research Article | First Published: June 30, 2016
Missing data are primarily due to dropout which can be categorized into different types based on its relation to the response process. For simplicity, it is generally assumed that the relation between a specific type of dropout and the response process can be described using a single (indicator) random variable. In case of distinct types of dropout, it is natural to use the multinomial indicator variables to model the dropout....
Open Access DOI:10.23937/2469-5777/1510039
Wilderness Care of Acute Traumatic Wounds Curriculum
Caleb D Sunde and Susanne J Spano
Article Type: Perspective | First Published: July 20, 2016
A comprehensive approach to wound care is critical when in the wilderness where definitive care may be hours, days or weeks away. The limitation of resources and the variety of acute traumatic wounds presents a management challenge. Resources for wilderness experiences with wound care are sparse. We developed an adaptable curriculum to teach participants of all levels how to appropriately manage wounds using established and improvised techniques....
Open Access DOI:10.23937/2469-570X/1410038
Stem Cells in Adult Homeostasis, Regeneration and Tissue Development of the Digestive Tract Epithelium
Valeria Fernandez Vallone and Marie-Isabelle Garcia
Article Type: Mini-Review | First Published: July 01, 2016
The gastrointestinal epithelium is one of the tissues with highest self-renewing rates under steady-state conditions, and it thereby constitutes an excellent model to better understand how tissues maintain homeostasis. In the past decade, intense research in this field has allowed identifying stem cells responsible for this task and has contributed to uncover the main molecular mechanisms associated with self-renewal and differentiation properties of these cells....
Open Access DOI:10.23937/2469-570X/1410037
Enteroendocrine Cells, A Potential Way to Control Intestinal Stem Cell Proliferation
Rihab Loudhaief and Armel Gallet
Article Type: Perspective | First Published: July 01, 2016
Organisms are subjected during their lifespan to many environmental stresses such as starvation, temperature variations, chemicals, pathogens, injuries... In order to overcome the incoming stress and to yield an adapted answer, organisms have developed throughout evolution robust and conserved mechanisms such as immune response and tissue regeneration helping at maintaining their physiological equilibrium, i.e. their homeostasis. However, the maintenance of the homeostasis can be compromised in ...
Open Access DOI:10.23937/2469-570X/1410036
Kartogenin Induced Chondrogenesis of Stem Cells and Cartilage Repair
Fazal-Ur-Rehman Bhatti, Karen A Hasty and Hongsik Cho
Article Type: Short Review | First Published: July 01, 2016
Osteoarthritis (OA) is predicted to be the fourth leading cause of disability in the world by the year 2020. OA results in damage to cartilage tissue and underlying subchondral bone. Current therapeutic options for osteoarthritis (OA) are limited due to the unique nature of cartilage tissue. Alternatively, mesenchymal stem cells (MSCs) have been utilized for cartilage repair, but the formation of an intact neocartilage similar to hyaline cartilage is still a challenge. Kartogenin (KGN), a small ...
Open Access DOI:10.23937/2469-584X/1510031
Hepatotoxicity from Alpha-Methyldopa During Pregnancy: Two Case Reports
Raul Adrover, Cecilia Siri, Daniel Cocozzella, Carlos Quarin, Juan Rome and Horacio Aziz
Article Type: Case Series | First Published: July 29, 2016
A 29-year-old woman in her third pregnancy (at 22 weeks), with a history of arterial hypertension under treatment with enalapril, which medication was switched to α-methyldopa on gestation week 8. She then began to experience coluria, generalized pruritus, and asthenia. Four days before consultation, she presented with jaundice. ...
Open Access DOI:10.23937/2474-3658/1510014
Essential Transition Metal Ion Complexation as a Strategy to Improve the Antimicrobial Activity of Organic Drugs
Graciela Borthagaray, Melina Mondelli and Maria H Torre
Article Type: Review Article | First Published: May 02, 2016
In order to maintain the capacity to treat infections it is necessary to adopt strategies for the development of new drugs. The use of metal ions in medicine for their antimicrobial effects was prevalent for many years before the advent of antibiotics. During the second half of the twentieth century, active metal complexes with different chemical, physicochemical and biochemical properties than the constituents reborn by the threat posed by microbial multidrug resistance....
Open Access DOI:10.23937/2572-4010.1510014
Eating Behavior in a Sample of Overweight and Obese: A Cross Sectional Study
Ahmed Salih Sahib, Tamara Sadeq Raheem, Maryam Shamal Saleh, Lina Saud khleel, Aya Mufeed Abdulhussein, Shams Reyadh Sadiq and Faris Abdul Kareem Kazaal
Article Type: Original Article | First Published: July 28, 2016
Obesity is becoming a public health problem worldwide especially in the recent years, thus; overweight and obesity are increasingly being observed among the population. The purpose of this study was to investigate the eating habits in a sample of overweight and obese Iraqi subjects who attend Al-Kindy obesity therapy and research unit....