Open Access DOI:10.23937/2572-407X.1510007

Myopathy Revealing Parathyroid Carcinoma

KS Moalla, N Bouzidi, M Damak, M Abid and C Mhiri

Article Type: Case Report | First Published: February 21, 2017

Primary hyperparathyroidism (PHPT) is defined as an inappropriate and excessive secretion of parathyroid hormone (PTH). It is usually asymptomatic and often diagnosed after a fortuitous discovery of hypercalcemia. We report the case of severe myopathy revealing PHPT secondary to parathyroid carcinoma (PC) with lung metastasis....

 Open Access DOI:10.23937/2378-3656/1410153

Misdiagnosis of Neurobehavoral Disorders Associated with Fetal Alcohol Exposure in Adults

Carl C Bell and Rochelle Gaudet

Article Type: Case Report | First Published: January 31, 2017

his case report addresses the misdiagnosis of Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE) in adults. The American Psychiatric Association's (APA's) Diagnostic and Statistical Manual - Fifth Edition (DSM-5) has proposed Fetal Alcohol Spectrum Disorders (FASD) be designated as ND-PAE. ND-PAE is prevalent in some contexts and populations, and is the cause of significant morbidity and mortality....

 Open Access DOI:10.23937/2378-3656/1410152

Cement Powder Ingestion: Case Report and Review of the Literature

Kim Lewis, Christopher Sheasgreen and Waleed Alhazzani

Article Type: Case Report | First Published: January 30, 2017

Alkaline material ingestions can cause a wide variety of injuries, ranging from mild to fatal. Cement is an alkaline agent and can lead to abrasions, allergic dermatitis, and chemical burns. There are very few case reports of cement ingestion in the literature. The gold standard for assessing the extent of injury after cement ingestionis via an esophagogastroduodenoscopy (EGD) within 12-24h....

 Open Access DOI:10.23937/2378-3419/1410077

Acetylation of α-tubulin by a Histone Deacetylase Inhibitor, Resminostat, Leads Synergistic Antitumor Effect with Docetaxel in Non-Small Cell Lung Cancer Models

Hiroaki Konishi, Akimitsu Takagi, Hiroyuki Takahashi, Satoru Ishii, Yu Inutake and Takeshi Matsuzaki

Article Type: Original Article | First Published: January 31, 2017

There is a growing body of clinical evidence to demonstrate that inhibition of histone deacetylase is effective in the treatment of various types of cancer. We examined whether acetylation of a non-histone protein α-tubulin was induced by resminostat and this acetylation exerts combination effects with docetaxel since α-tubulin was a target of docetaxel....

 Open Access DOI:10.23937/2378-3419/1410076

Trastuzumab Emtansine in Patients with HER2-Positive Metastatic Breast Cancer: a Multicenter Japanese Retrospective Study

Masako Sato, Masato Takahashi, Kenichi Watanabe, Nobumoto Tomioka, Mitsugu Yamamoto, Yoshiaki Narita, Hiroaki Kato, Masaru Abe, Yukiko Tabata, Masaya Kawada, Motoshi Tamura, Mitsuchika Hosoda, Motoi Baba, Kazuhiro Ogasawara, Tomohiro Oshino, Hiromitsu Akabane, Yasuhiro Suzuki, Masatoshi Kadoya, Kazuhiro Iwai, Yumi Okawa, Kenjiro Misu, Kazuomi Ichinokawa and Hiroko Yamashita

Article Type: Original Article | First Published: January 30, 2017

Trastuzumab emtansine (T-DM1) is currently approved for the treatment of patients with HER2-positive metastatic breast cancer after failure of prior anti-HER2 therapies. However, the efficacy of T-DM1 in patients who received pertuzumab, and in those patients with brain metastases, is currently unclear....

 Open Access DOI:10.23937/2378-2951/1410089

Type A Aortic Dissection in an Asymptomatic 28-Week Pregnant Patient with Marfan Syndrome

Mario Gioia, Reehan Shahzad and Jordan Safirstein

Article Type: Case Report | First Published: January 21, 2017

Acute aortic dissection during pregnancy is a rare and potentially fatal disease. Connective tissues disorders, including Marfan syndrome, in combination with the physiological stress of pregnancy and delivery substantially increase the risk of aortic dissection. It is vital to recognize symptoms early, if present, in order to undergo medical and surgical management to increase the chance of survival....

 Open Access DOI:10.23937/2378-2951/1410088

Timing of Catheterization Post Cabg Surgery: (Tic-Postcabg)

Nasser Hayat, Jadan Al Saddah, Mohammad Al Mutairi, Mariam Abdulla Almelahi and PRS Remya

Article Type: Original Article | First Published: January 20, 2017

Post coronary artery bypass graft (CABG) patients were arbitrarily divided into 2 groups at the time of cardiac catheterization. Catheterization was performed because of ischemic manifestations. Group A had their surgery less than 5 years. Group B had their surgery more than 5 years....

 Open Access DOI:10.23937/2377-4630/1410055

A Case Report: Adaptive Servo Ventilation for a Patient with Acute Heart Failure and Central Sleep Apnea

Chol Kim, Yoshihiko Seino and Atsuhiro Sakamoto

Article Type: Case Report | First Published: January 18, 2017

A 50-year-old male presented to the emergency room at night with complaints of paroxysmal nocturnal dyspnea and worsening shortness of breath on exertion. He was an active tireless estate agent till three months before, when he noticed shortness of breath on climbing the stairs at the station....

 Open Access DOI:10.23937/2469-5823/1510061

Brief Report: Von Willebrand Disease in Women: A Review and APN Survey Results

Jennifer P Kurkowski, Angelo P Giardino, Jennifer E Dietrich and Haleh H Sangi

Article Type: Review Article | First Published: January 20, 2017

Approximately 3 million women in the United States are estimated to have an inherited bleeding disorder, VWD being the most common and affecting 1% of the population. Pathophysiology, prevalence, relationship to heavy menstrual bleeding, screening and appropriate workup for VWD are discussed. Advanced practice nurses were surveyed about the amount of education on bleeding disorders and revealed 59% were taught about Type 1 Von Willebrand disease in school. Furthermore, 62.2% of participants felt...

 Open Access DOI:10.23937/2474-3631/1510024

Homelessness and the Length of Stay in Psychiatric Wards

Walid Khalid Abdul-Hamid, Shefalica Bhan-Kotwal, Pratap Kovvuri and Stephen Stansfeld

Article Type: Research Article | First Published: January 26, 2017

To study the effects of homelessness on length of stay in psychiatric wards. All 37 admissions of homeless people to an acute psychiatric service during the year 2005 were identified using the Carebase system. Admissions of homeless people were then compared to a random sample (of 62 admissions) from the total number of admission during 2005 (397 admissions)....