Open Access DOI:10.23937/2474-1353/1510044
Overview of Locally Advanced Breast Cancer: A Huge Challenge to Science
Francine Carla Cadona, Alencar Kolinski Machado, Marco Aurelio Echart Montano, Charles Elias Assmann and Ivana Beatrice Manica da Cruz
Article Type: Review Article | First Published: February 10, 2017
Cancer incidence and cancer-related deaths are dramaticallys rising worldwide. In women, current estimates show high incidence of breast cancer (BC). BC is considered the second most frequent cancer-related death causer in women worldwide, responsible for millions of deaths each year. However, BC early diagnosis improves treatment success and increase survival rates. Physical examination, mammography, ultrasound, magnetic resonance imaging are techniques that auxiliary BC diagnosis....
Open Access DOI:10.23937/2469-570X/1410045
Secretome of Mesenchymal Stem Cells Grown in Hypoxia Accelerates Wound Healing and Vessel Formation In Vitro
Sushma Bartaula-Brevik, Anne Isine Bolstad, Kamal Mustafa and Torbjorn O Pedersen
Article Type: Original Article | First Published: February 20, 2017
Hypoxia is one of the factors that trigger the release of inflammatory and vasculogenic cytokines during tissue regeneration. Mesenchymal stem cells (MSC) with and without endothelial cells (EC) were cultured in vitro in normoxic and hypoxic environments. The mRNA expression of inflammatory and vasculogenic cytokines were evaluated at 1, 12, 24 and 48 hours. After 48 hours of incubation in normoxic and hypoxic conditions, supernatants termed as conditioned medium (CM) from each group were collec...
Open Access DOI:10.23937/2378-3516/1410067
A Single Center Review of Pleural Fluid Samples
C Walker, J Mackenzie, J Aust, J Port, D Cooper, S Parker, S Bourke, J Miller, M Weatherhead and A Aujayeb
Article Type: Research Article | First Published: February 20, 2017
All pleural aspirations done between January 1st 2014 and December 31st 2015 were analyzed for fluid biochemistry, microbe, cytology and final diagnoses (n = 264). Light's criteria were applied wherever possible. The fluid biochemistry, microbiology and cytology results were assimilated from the local electronic results system. The patient diagnosis was taken from clinic letters electronically uploaded to another system called SingleView. Local governance approval was sought and obtained....
Open Access DOI:10.23937/2378-3516/1410066
Seromucinous Hamartoma Presenting as an Obstructive Endobronchial Mass
Guang-Qian Xiao and Sapna Patel
Article Type: Case Report | First Published: February 10, 2017
Seromucinous hamartoma is an extremely rare entity that has been described in the sinonasal cavity and nasopharynx. We here present a case of seromucinous hamartoma manifesting as an obstructive endobronchial mass in a 65-year-old male and active smoker, who presented with dyspnea upon prolonged exertion and atelectasis....
Open Access DOI:10.23937/2378-3516/1410065
Effects of Chest Physical Therapy in Patients with Non-Tuberculous Mycobacteria
Basavaraj Ashwin, Segal Leopoldo, Samuels Jonathan, Feintuch Jeremy, Feintuch Joshua, Alter Kevin, Moffson Daniella, Scott Adrienne, Addrizzo-Harris Doreen, Liu Mengling and Kamelhar David
Article Type: Original Research | First Published: January 21, 2017
Antibiotic therapy against non-tuberculous mycobacteria (NTM) is prolonged and can be associated with toxicity. We sought to evaluate whether chest physical therapy (PT) was associated with clinical improvement in patients with NTM not receiving anti-mycobacterial pharmacotherapy. A retrospective review of 77 subjects that were followed from June 2006 to September 2014 was performed. Baseline time point was defined as the first positive sputum culture for NTM; symptoms, pulmonary function, and r...
Open Access DOI:10.23937/2572-4037.1510016
An Overview of Cognitive-Behavioral Interventions for Promoting Adaptive Skills of Children with Angelman Syndrome
Fabrizio Stasolla and Viviana Perilli
Article Type: Review Article | First Published: February 25, 2017
This paper provides the reader with a concise overview of the empirical evidences available in the last decade on the use of cognitive-behavioral interventions for promoting adaptive skills of children with Angelman syndrome. The results were fairly positive, although no documents were found on the implementation of assistive technology-based programs. Some useful suggestions for future research and practice within this framework were briefly discussed....
Open Access DOI:10.23937/2378-346X/1410066
Haemophilus Influenzae Endophthalmitis Associated with a Glaucoma Drainage Implant in an Adult
Bac T Nguyen, Patricia Chevez-Barrios, Robert E Coffee and Benjamin J Frankfort
Article Type: Case Report | First Published: January 27, 2017
A 65-year-old male with primary open-angle glaucoma underwent tube shunt surgery with an Ahmed Glaucoma Valve FP-7 (New World Medical, Rancho Cucamonga, CA) in the left eye for uncontrolled intraocular pressure, worsening visual field defects, and advanced glaucomatous optic neuropathy. In that eye, the patient had previously undergone selective laser trabeculoplasty, phacoemulsification with posterior chamber intraocular lens placement, and pars plana vitrectomy for rhegmatogenous retinal detac...
Open Access DOI:10.23937/2469-5742/1510022
The Role of Hyperbaric Oxygen Therapy in Andrology
Donghua Xie, Boris Klopukh, Guy M Nehrenz and Edward Gheiler
Article Type: Review Article | First Published: February 13, 2017
Hyperbaric oxygen (HBO) therapy is a supplemental treatment, in addition to the converntional approach, for patients with an underlying ischemic process. In Andrology, HBO is a therapeutic approach supplemental to surgical and medical options for some patients, mainly reported in the treatment of perineal necrotizing fasciitis (Fournier's gangrene). There were also case reports of successful management using the HBO therapy for posttraumatic ischemic injury, infertility caused by varicocele, hyd...
Open Access DOI:10.23937/2377-4630/1410057
Trachway Intubating Stylet Facilitates the Double-Lumen Endobronchial Tube Placement in Patients with Limited Mouth Opening
Wen-Ming Chuang, Hung-Te Hsu, Shah-Hwa Chou, Chia-Chen Wu, Kuang-Yi Tseng, Kuang-I Cheng and Miao-Pei Su
Article Type: Case Report | First Published: March 13, 2017
Intubation for one lung ventilation in patients with difficult airways can be a challenge. Severely limited mouth opening restricts the use of direct laryngoscopy or video-assisted laryngoscopy. We present two patients with limited mouth opening undergoing video-assisted thoracoscopic decortication, who were successfully intubated with left-sided double-lumen endobronchial tube (DLT) using the Trachway® intubating stylet. This technique provides a safe and reliable method for DLT intubation ...