Open Access DOI:10.23937/2469-5823/1510065

Using Quality Improvement Methods to Implement Guidelines to Decrease the Proportion of Urinary Retention in Orthopaedic Care

Ann-Christine Andersson, Rose-Marie Johansson, Mattias Elg, Boel Andersson Gare and Lennart Christensson

Article Type: Original Research | First Published: March 09, 2017

In patients treated with indwelling urethral catheter (IUC), complications such as catheter associated urinary tract infections are common, while underuse of IUC may cause harmful urinary retention (UR)....

 Open Access DOI:10.23937/2469-5823/1510064

Reliability and Validity of Drugs Use Health Belief Scale in Adult Women

Behice Erci and Zeynep Cicek

Article Type: Research Article | First Published: March 07, 2017

The research was methodological study design. A convenience sample of 210 women at a primary health care centre completed a structured questionnaire including the health beliefs related drug use scale for women in 2012. The researchers visited primary health care centre on 5 working days in every week and conducted interviews with the women....

 Open Access DOI:10.23937/2469-5823/1510063

Improving Practitioners Knowledge and Confidence to Identify High Risk Medications with Older Adults: A Quality Improvement Intervention

Ellen O Beyer and Jeungok Choi

Article Type: Original Article | First Published: March 02, 2017

Adults 65 years and older are at increased risk for complications of drug therapy and are vulnerable to medication prescribing patterns of poor quality because of age-related changes, comorbidities, polypharmacy, and medication interactions. Potentially inappropriate medications contribute to adverse drug events, falls, delirium, and gastrointestinal bleeding and are deemed preventable....

 Open Access DOI:10.23937/2469-5823/1510062

Self-Perceived Competency-Based Training Needs of Registered Nurses: A Cross-Sectional Exploratory Study

Lap Fung Tsang, So Yuen Alice Sham, Sheung Lan Winnie Law, Shuk Chun Irene Ho, Siu Keung Tang, Ching Yan Kong, Suk Ying Peggy Wong and A Marie Tarrant

Article Type: Review Article | First Published: February 25, 2017

The aim of this study is to explore a competency-based training need of registered nurses working in United Christian Hospital (UCH) in Hong Kong. This cross-sectional questionnaire study included 876 registered nurses from 3 to 23 August 2015....

 Open Access DOI:10.23937/2469-5750/1510043

Report a Case of Linear Iga Bullous Dermatosis During Gestation and Minor Review for Features of Different Subtypes and Differential Diagnosis

Xiaoyue Wang, Pengfei Song and Jing Wang

Article Type: Case Report | First Published: February 25, 2017

Linear IgA bullous dermatosis (LABD) is a rare auto-immune bullous disease occurring in adults or childhood. There are similarities and differences between these two subtypes of the disease. We report a twenty-seven-year-old patient with adult subtype of LABD. The disease started from the second month of gestation and remitted after the delivery....

 Open Access DOI:10.23937/2572-3235.1510022

Comparison of Arterial Spin Labeling and Dynamic Susceptibility Contrast-Enhanced MR Perfusion in Differentiating Tumor Recurrence from Treatment-Related Changes

Robert J Bert, William Colantoni III, Douglas E Ney, Denise M Damek, Bette K Kleinschmidt-DeMasters and Manuel Thomas Borges

Article Type: Original Research | First Published: February 24, 2017

MR dynamic susceptibility contrast-enhanced perfusion (DSC) has demonstrated utility in the evaluation of follow-up malignant CNS neoplasms. Preliminary studies suggest Arterial Spin Labeling (ASL) perfusion may be equivalent for this purpose. Using a retroprospective, blinded test design, we compared interpretations of ASL and DSC in tumor follow-up....

 Open Access DOI:10.23937/2469-5858/1510022

Diagnosis of Dementia-Circadian Dependency?

Wolfgang Trapp, Robert Meyrer, Goran Hajak and Stefan Lautenbacher

Article Type: Short Communication | First Published: February 16, 2017

Little is known whether tests used for the diagnosis of dementia syndromes are sensitive to time of day effects. In a sample of 145 participants, no such effect (test administration either in the morning from 9.30 to 11.30 a.m. or in the afternoon from 2.30 to 4.30 p.m.) could be found for most subtests of a neurocognitive test battery (CERAD-Plus) used for the detection of dementia syndromes....

 Open Access DOI:10.23937/2469-5858/1510021

Phase II Clinical Trial of Nicotinamide for the Treatment of Mild to Moderate Alzheimer's Disease

Michael J Phelan, Ruth A Mulnard, Daniel L Gillen and Steven S Schreiber

Article Type: Research Article | First Published: February 14, 2017

Disease-modifying treatments for Alzheimer's disease (AD) are currently unavailable and are the focus of an intensive research effort. We found vitamin B3, nicotinamide (NA), to significantly reduce pathology and improve behavior in AD transgenic mice. These results led us to conduct a double-blind, placebo-controlled randomized clinical trial of NA in mild to moderate AD....

 Open Access DOI:10.23937/2572-4193.1510029

In Vitro Modulation of MMP-2 and MMP-9 Secretion by Cytokines, Inducers, and Inhibitors in Head and Neck Squamous Carcinoma Cells (FaDu) and Tongue Carcinoma Cells (SCC-25)

M Waheed Roomi, Bilwa Bhanap, Aleksandra Niedzwiecki and Matthias Rath

Article Type: Research Article | First Published: February 21, 2017

Head and neck squamous cell carcinoma (HNSCC) is a devastating disease with poor prognosis. Matrix metalloproteinases (MMPs), specifically, MMP-2 and MML-9 play a critical role in tumorigenesis by their ability to modify tumor microenvironments, facilitating cell invasion and metastasis. We compared MMP secretion by various cytokines, inducers, mitogen, inhibitors that regulate MMP-2 and MMP-9 activities in FaDu and Tongue cancer cell lines....

 Open Access DOI:10.23937/2474-3674/1510023

Emerging Concepts in Acute Heart Failure: From the Pathophysiology to the Clinical Case Based Approach

Antonio Giovanni Solimando, Antonella Argentiero, Anna Ruckdeschel, MaxBittrich, Andreas Schneider, Rodolfo Sbrojavacca, Angelo Vacca, Georg Fritz and Hermann Einsele

Article Type: Case Report | First Published: February 25, 2017

Acute heart failure (AHF) represents a heterogeneous clinical syndrome, comprising new or worsening signs and symptoms on a background of stable chronic heart failure (HF), as well as new-onset HF. In either clinical picture, urgent care is crucial. Given the variety of clinical scenario, stratifying patient subgroups on a pathophysiologic base can help direct appropriate therapy. ...