Open Access DOI:10.23937/2469-570X/1410049

Adult Stem Cell Therapy in Liver Cirrhosis Management: Current Practices and Future Perspectives

Sellamuthu Subbanna Gounder, Radha Kodiappan, Soon Choy Chan, Abhi Veerakumarasivam and Baskar Subramani

Article Type: Review Article | First Published: September 26, 2017

Liver cirrhosis is a leading cause of mortality worldwide. Although treatable by liver transplantation, quality of life is unlikely to drop in all the patients after five years. The shortage of matching donors and the high risk of surgical-associated complications further limits the therapeutic potential of transplantation....

 Open Access DOI:10.23937/2469-570X/1410048

Reduction of Gingival Black Triangles with Dental Pulp or Gingival Stem Cell Injection Therapy: Clinical and Outcomes Research Gaps

Jennifer Hilario Diaz and Jordana Kate Schmier

Article Type: Review Article | First Published: August 31, 2017

Gingival Black Triangles (GBTs), or gingival embrasures, are aesthetically displeasing even when they are not severe enough to require periodontal treatment. Multiple treatment modalities exist, including veneers, composite and other prosthetic modalities, with few, if any, treatments covered by insurance....

 Open Access DOI:10.23937/2469-567X/1510034

Dual Cytomegalovirus and Aspergillus Pneumonia Following Influenza B Infection in a Patient with Polyarteritis Nodosa

Chiu-Yin Yeh, Hsi-Hsing Yang and Wen-Liang Yu

Article Type: Case Report | First Published: September 20, 2017

Polyarteritis Nodosa (PAN) is a systemic necrotizing vasculitis that might require immunosuppressive therapy. We report on a 72-year-old woman of PAN with influenza B infection, who developed dual cytomegalovirus and Aspergillus pneumonia in the later course....

 Open Access DOI:10.23937/2469-5696/1410027

Interstitial Deletion of Chromosome 9q in Therapy-Related Acute Promyelocytic Leukemia with Pathognomonic t(15;17) in a Patient Exposed to Radioactive Iodine

Poorva Bindal, Heenam Goel, Alexei Shimanovsky, Joseph M Ryan, Jeffrey S Wasser and Enrique Ballesteros

Article Type: Case Report | First Published: September 29, 2017

The incidence of therapy-related Acute Promyelocytic Leukemia (t-APL) has been steadily rising. Radioactive Iodine (RAI) has emerged as a potential leukemogenic insult. Translocation involving the Retinoic Acid Receptor-alpha (RAR-alpha, RARa) gene on chromosome 17 and the Promyelocytic Leukemia (PML) gene on chromosome 15....

 Open Access DOI:10.23937/2469-5866/1510019

Microglial NLRP3 Activity in Alzheimer's Disease

Bruno Cabral de Lima Oliveira

Article Type: Review Article | First Published: September 11, 2017

Alzheimer's Disease (AD) is the major disease leading to dementia. This disease is characterized by the presence of β-Amyloid (Aβ) extracellular deposits and neurofibrillary tangles, which induce senile plaques formation. Furthermore, inflammation in AD is mainly mediated by innate immunity-related cells, especially microglia....

 Open Access DOI:10.23937/2572-4061.1510008

Assessment of Environmental Contamination by Wastewater from a Cocoa Processing Industry Using Genetic and Reproductive Biomarkers

Alabi A Okunola, Esan E Babatunde, Olorunfunmi J Temitope and Oludare O Evelyn

Article Type: Research Article | First Published: September 25, 2017

Food industries are among the major contributors to industrial wastes. Their wastewaters can pose a threat if untreated and indiscriminately disposed into the environment. In this study, we investigated the potential genetic and reproductive toxicity of Cocoa processing industry wastewater, by using the mouse Micronucleus (MN) and sperm morphology assays....

 Open Access DOI:10.23937/2572-4053.1510017

Sleep, Nightmares and Schizophrenia

Mary V Seeman

Article Type: Case Report | First Published: October 19, 2017

Sleep problems are recognized as widespread in patients with psychosis. Other facts are known as well - that not only can psychiatric illness result in sleep problems, but that these same problems can exacerbate psychopathology and that they constitute risk factors for suicide....

 Open Access DOI:10.23937/ijrdd-2017/1710001

Hereditary Ichthyosis and Achieving the Oral Mucosa, Retrospective Study of 33 Cases

Pr Omar Boudghene Stambouli and Dib Lachachi Amina

Article Type: Case Study | First Published: October 19, 2017

This is the most frequent and is transmitted on an autosomal dominant mode. It appears from the first months of life and is manifested by flaky scales on the faces of extension of the limbs and convexities in general. The face and the large folds are respected....

 Open Access DOI:10.23937/2469-5831/1510012

A Systematic Approach to Increase Reproducibility in Simulation Studies

Xiaoyong Wu and Shesh N Rai

Article Type: Research Article | First Published: October 07, 2017

Reproducibility of results in simulation studies plays a key role in statistical science. Although P-value occupies a prominent place for determining statistical significance in replicate studies, there is always possibility of extra variability across samples leading to irreproducible results. Recently, Halsey, et al....

 Open Access DOI:10.23937/2469-5831/1510011

Can We Identify Patients at High Risk of Harm under a Generally Safe Intervention?

Gerd K Rosenkranz

Article Type: Research Article | First Published: September 23, 2017

Personalized medicine today is primarily addressing efficacy. Here we investigate and illustrate the role that precision medicine could play in drug safety by supporting the identification of subjects at high risk of harm by an otherwise safe and efficacious treatment. Predicting potential harm requires high sensitivity of a classification rule....