Open Access DOI:10.23937/2572-3987.1510013

Novel Concepts for Clinical Pharmacology from

Leandro Bueno Bergantin and Afonso Caricati-Neto

Article Type: Mini Review | First Published: November 24, 2017

The solution for the so-called "calcium paradox" has been revealed 4 years ago, when we demonstrated the involvement of the interaction between Ca2+ and cAMP signalling pathways (Ca2+/cAMP signalling interaction) in this enigma....

 Open Access DOI:10.23937/2469-5742/1510034

Embolization in the Treatment of a Major Retropubic Hemorrhage Following Tension-Free Vaginal Tape: A Case Report and Literature Review

Margrethe Foss Hansen, Mads Henrik Carstensen, Jens Prien-Larsen and Lars Alling-Møller

Article Type: Case Report | First Published: November 20, 2017

55-year-old para 2 woman was brought to the emergency department following insertion of a tension-free vaginal tape complaining of lower abdominal pain and vertigo. The subsequent angiography localized a significant bleeding from the right obturator artery and a retropubic hematoma 17.5 cm × 10.0 cm in size....

 Open Access DOI:10.23937/IAPHCM-2017/1710002

Neck Pain and Low Back Pain in Medical Students: A Cross-Sectional Study

Jerry Y Du, Alexander Aichmair, Joshua E Schroeder, Paul D Kiely, Joseph T Nguyen and Darren R Lebl

Article Type: Research Article | First Published: November 18, 2017

Neck Pain (NP) and Low Back Pain (LBP) are among the top four major causes of disability. There is a paucity of data regarding the prevalence and Quality of Life (QOL) issues associated with NP and LBP in American medical students. The aim of the present study was to characterize NP and LBP in American medical students....

 Open Access DOI:10.23937/iaoms-2017/1710003

Tissue Dimensional Changes Following Alveolar Ridge Preservation with Different Xenografts Associated with a Collagen Membrane. Results at the 4-Month Re-Entry Surgery

Guarnieri Renzo, Stefano Ippoliti, Stefanelli Luigi, De Angelis Francesca, Di Carlo Stefano and Pompa Giorgio

Article Type: Research Article | First Published: October 09, 2017

The aim of the present study was to clinically and histologically evaluate outcomes of alveolar ridge preservation technique using a collagen membrane associated to bovine-derived bone (MB), and a collagen membrane associated to porcine-derived bone (MP)....

 Open Access DOI:10.23937/2469-567X/1510036

p53 Expression Activation of HIV-1 Latency in U1 Cells

Xue Wang , Jiangqin Zhao, Christelle Mbondji and Indira Hewlett

Article Type: Research Article | First Published: November 18, 2017

Latent infection is a major barrier for cure of HIV-1 infection. HIV-1 is capable of establishing latency when its host cells undergo apoptosis and initiate replication in response to this effect. HIV infection results in increased p53 expression that enhances replication in primary infection....

 Open Access DOI:10.23937/2469-5823/1510084

Effectiveness of Simulation among Undergraduate Students in the Critical Care Nursing

Melba Sheila D'Souza, Ramesh Venkatesaperumal, Frieda S Chavez, Kader Parahoo and Devakirubai Jacob

Article Type: Research Article | First Published: November 18, 2017

Novice nursing students are trained to develop skills for delivering safe patient-centered holistic care in the undergraduate nursing. Entry of novice students in the higher levels of the undergraduate curriculum entails their adult clinical experience in the intensive care, high acuity, post-anesthetic and emergency settings....

 Open Access DOI:10.23937/iacvd-2017/1710002

Hyper-Homocysteinemia and other Inherited Thrombophilic Factors Inducing Retinal Vein Occlusion. The Employment of Novel Orals Anti-Coagulants is Possible?

Federico Cacciapuoti

Article Type: Review Article | First Published: November 18, 2017

Retinal Vein Occlusion (RVO) is the second cause of unilateral visual loss, and can have ischemic or non-ischemic aetiology. The causes inducing RVO may be due to thrombophilia induced by acquired or inherited risk factors....

 Open Access DOI:10.23937/2378-3419/1410089

Clinical Utility of Serum Human Epidermal Growth Factor Receptor Type 2 Testing as a Marker of Therapeutic Response In Tissue HER2-Positive Breast Cancer Patients

Seiichi Mokuyasu and Yasuhiro Suzuki

Article Type: Original Article | First Published: November 18, 2017

Human Epidermal growth factor Receptor type 2 (HER2) is over expressed in 20.0-30.0% of breast cancers and is currently evaluated histopathologically. Immunohistochemistry and fluorescence in situ hybridization require invasive enucleation of the tumor tissue and may be affected by heterogeneity....

 Open Access DOI:10.23937/2378-3419/1410088

Ipilimumab Activity in Advanced Uveal Melanoma: A Pooled Analysis

Muhammad A Khattak and Elin Gray

Article Type: Original Research | First Published: November 18, 2017

Uveal Melanoma is a rare tumour that displays different clinical behavior and molecular features compared with cutaneous melanoma. It is generally resistant to systemic therapy and there is no current standard effective therapy to treat patients with advanced disease....

 Open Access DOI:10.23937/2378-3419/1410087

Immune Paralysis and the Spontaneous Remission of Cancer

BH Behzad Niakan

Article Type: short review article | First Published: November 16, 2017

Once a malignant growth grows past a certain size immune tolerance rather than immune sensitization occurs possibly due to the slow tumor growth. As the malignant grows larger some branches of the immune system (adoptive immunity) become protective of it, while other branches of the immune system oppose its growth....