Open Access DOI:10.23937/2378-3648/1410039

A Novel Mutation in the MFN2 Gene Associated with Hereditary Sensory and Motor Neuropathy with Proximal Predominance (HMSN-P)- A Case Report

D Hettiaracchchi, K Weththasigha, N Nethikumara, S Pathirana and WHV Dissanayaka

Article Type: Case Report | First Published: October 17, 2018

Mutations in mitofusin 2 gene have been reported in Charcot-Marie-Tooth type 2 disease also known as Hereditary Sensory and Motor Neuropathy. With its cytogenetic location: 1p36.22. A 43-year-old female with a family history of neuropathy was experiencing gradual detrition and proximal weakness of the bilateral lower limb for the past 3 years. Her MRI scan (Brain and whole Spinal) was normal and Electromyography (EMG) report was suggestive of motor & sensory demyelinating polyneuropathy with fea...

 Open Access DOI:10.23937/2378-3419/1410098

Response Prediction to Neoadjuvant Chemotherapy Prior to Interval Debulking Surgery and the Outcome of Responders Compared to Nonresponders

Michal Levy, Joseph Menczer, Mona Boaz, Ayelet Wandel, Yossi Mizrachi and Tally Levy

Article Type: Research Article | First Published: October 17, 2018

Neoajuvant Chemotherapy (NACT) followed by Interval Debulking Surgery (IDS) is an acceptable therapeutic approach for selected patients with advanced stage Ovarian Carcinoma (OvC) and Primary Peritoneal Carcinoma (PPC) patients. Our aim was to assess whether the combined presence of reduction of the diameter of the largest tumor mass and of the CA125 level predict response to Neoadjuvant Chemotherapy (NACT). Clinicopathological data were abstracted from medical records of consecutive OvC and PPC...

 Open Access DOI:10.23937/iaoms-2017/1710011

Treatment of Acquired Retrognathia Secondary to Infantile Temporomandibular Joint Luxation with Intraoral Vertico-Sagittal Ramus Osteotomy

Khaled Gamal Dahy, Katsu Takahashi, Honoka Kiso, Kensaku Aihara, Kazuo Chin and Kazuhisa Bessho

Article Type: Case Report | First Published: October 17, 2018

Temporomandibular joint (TMJ) disorders are under-diagnosed in pediatric patients, and infantile TMJ luxation is a very rare condition. Luxation early in life can cause skletofacial problems, such as retrognathia, if it is left untreated for a long time. It is well known that severe retrognathia is one of the most common causes of sleep-disordered breathing (SDB). The authors report a case of infantile TMJ luxation with secondary retrognathia associated with SDB, in which intraoral vertico-sagit...

 Open Access DOI:10.23937/2469-5718/1510106

Physical Activity in the Prevention of Abdominal Obesity: Type, Duration and Intensity

Francisco Jose Gondim Pitanga, Cristiano Penas Seara Pitanga and Carmem Cristina Beck

Article Type: Opinion | First Published: October 17, 2018

To suggest the type and dose (duration and intensity) of physical activity more adequate to prevent abdominal fat in adults. The evidences that were presented are part of studies on physical activity and abdominal fat published in the national and international literature. Physical activity (aerobic and resistance exercises), with a prolonged duration of moderate intensity for men and walking or moderate intensity for women, is suggested as the most adequate for the prevention/treatment of abdom...

 Open Access DOI:10.23937/2378-3516/1410092

Identification and Molecular Epidemiology of Mycobacterial Isolates in Kayseri/Turkey

Murat KARAUZ, A Nedret KOC and Altay ATALAY

Article Type: Original Article | First Published: October 17, 2018

Early diagnosis and treatment of tuberculosis (TB) patients are the most effective ways to protect society from this disease. The objectives of this study were to evaluate the molecular epidemiology of mycobacterial strains by repetitive sequence PCR (rep-PCR) using the DiversiLab System method at Kayseri in Turkey. A total of fifteen clinically sample isolated Mycobacterial strains were identified as M. tuberculosis complex (MTBC) and non-tuberculous mycobacteria (NTM) by the rep-PCR method (bi...

 Open Access DOI:10.23937/2572-4037.1510032

Pathogenic Beliefs and their Relevance in Psychotherapy: A Written Case Study

Jennifer Kadur, Irina Flaig, Jana Volkert, Isa Sammet and Sylke Andreas

Article Type: Case Study | First Published: October 17, 2018

Goals of this single-case study are to assess whether tests according to Control Mastery Theory (CMT) can be reliably identified by trained raters and to examine whether the Psychotherapy Process Q-Sort method can adequately represent the test situation. A single case was analyzed by well-trained psychology graduates on the basis of the Plan Formulation Method. The interrater reliability of the identified tests was examined. In addition, the tests were classified according to the Psychotherapy P...

 Open Access DOI:10.23937/2469-5726/1510067

Rheumatologic Diseases as Paraneoplastic Syndromes - A Paradigmatic Case

Ines Rego de Figueiredo, Rita Vieira Alves, Sara Guerreiro Castro, Filipa Lourenco, Ana Margarida Antunes, Heidi Gruner and Antonio Panarra

Article Type: Case Report | First Published: October 15, 2018

Rheumatic diseases can be a paraneoplastic syndrome for an occult neoplasia. Some syndromes are more characteristic than others. In this case report, we present a patient with musculoskeletal symptoms suggestive of both carcinomatous arthritis and polymyalgia rheumatica that was shown to have adenocarcinoma of the lung. The musculoskeletal symptoms accompanied the course of the disease, disappearing with the treatment and re-occurring when it relapsed. We present a 63-year-old male, native from ...

 Open Access DOI:10.23937/2469-5793/1510092

Impact of Core Electronic Health Record Functionalities on Cardiovascular Disease Preventive Health Services for Underserved Patients

Christopher K Rogers

Article Type: Research Article | First Published: October 15, 2018

Examine differences in the associations between core Electronic Health Record (EHR) functionalities for public and population health, care coordination, patient engagement, and quality improvement on the provision of recommended Cardiovascular Disease (CVD) preventive health services provided at Primary Care Visits (PCVs) for CVD at-risk adults with Medicaid and those with private insurance. Utilizing a nationally representative survey of ambulatory care visits by patients at risk for CVD in 201...

 Open Access DOI:10.23937/2469-5793/1510091

Blue Finger Syndrome in an Elderly Patient

Castillo-Santizo JJ, Alvarez-Perez E, Gonzalez-Lopez A, Blanco-Rubio C, Ortega-Calvo M and Gabaldón-Rodriguez I

Article Type: Case Report | First Published: October 15, 2018

This article presents a case of an 88-year-old man who shows blue-violaceous discoloration on his fingers and toes, with a greater intensity on the third finger of right hand and the first, second and third toe of his right foot. The patient had been recently diagnosed with atrial fibrillation and met the criteria for oral anticoagulation with acenocoumarol, which had started two weeks earlier. When the treatment was discontinued, the bluish color of his fingers disappeared, for which reason the...

 Open Access DOI:10.23937/2377-3634/1410096

Insulin Resistance Modification is a Game Changer for Type 2 Diabetes Treatment Strategy

Juraj Gmitrov

Article Type: Review Article | First Published: October 15, 2018

Insulin resistance, appearing years before diabetes main diagnostic sign, hyperglycemia, stands in the origin of type 2 diabetes (T2DM), generated by complex impairment of a spectrum biochemical processes the most important of which is the failure of phosphatidylinositol 3-kinase enzymatic chain responsible for glucose uptake and endothelial nitric oxide (NO) synthase activation. Therefore in conditions with insulin resistance the impairment of glucose uptake is strongly coupled with NO deficit ...