Open Access DOI:10.23937/2378-346X/1410152
Evaluation for Anatomical Success in Macular Hole Surgery in Cambodian Population
Leng Un, Piseth Kong, Amrin Mar and Guechlaing Chea
Article Type: Research Article | First Published: 2024/06/17
This was a prospective study on patients operated for idiopathic MH at Preah Ang Duong Hospital. Patients underwent pars plana vitrectomy with inverted internal limiting membrane (ILM) flap and postoperative prone positioning. The primary outcome measure was anatomical closure of MH. The secondary outcome measure was postoperative best-corrected visual acuity (BCVA) and ocular complications....
Open Access DOI:10.23937/2377-3634/1410182
Pathophysiology of the Skin in Type 1 and Type 2 Diabetes and Emerging Therapeutic Opportunities
Priyanka Prabhakar Poonja, MBBS, MSc and Flora Kiss, MD, PhD
Article Type: Review Article | First Published: 2024/05/31
Skin manifestations of diabetes mellitus (DM) occur as a result of impaired insulin signalling, insulin resistance and chronic hyperglycemia. The biophysical properties of the outer barrier of the epidermis the stratum corneum (SC), reflect the status of both epidermal function and systemic conditions, with over two-thirds of DM patients known to experience skin involvement....
Open Access DOI:10.23937/2572-4061.1510057
Hepatoprotective Efficacy of Phytochemicals in Clerodendrum volubile as Potential Natural Inhibitor on CYP2e1 Protein Implicated for Toxicity in Liver
Ololade Zacchaeus S, Onifade Olayinka F, Olugboye Bolarinde O, Alabi Temidayo E, Faleye Busayo C and Jimson Favour E
Article Type: Review Article | First Published: 2024/06/13
This study delves into the effects of secondary metabolites in Clerodendrum volubile on CYP2e1, a protein target implicated in hepatotoxicity. Among these compounds, cis,cis-linoleic acid, 3-hydroxydecanoic acid, n-pentadecanoic acid, palmitic acid, and 3,5-dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one demonstrate strong binding affinities and stability within the protein's active site compared to standard compounds with lower values. These compounds exhibited notable binding affinities against ...
Open Access DOI:10.23937/2469-5734/1510164
Reducing HPV-Associated Oropharyngeal Cancer Risk and Exploring the Role of Safe Sexual Activity and Behavioral Modifications
Chinonyelum Emmanuel Agbo, B.Pharm, Uzochukwu Emmanuel Chima, B.Pharm, Olanrewaju Faith Omotayo, B.Pharm, Jideofor Collins Amoke, B.Pharm, Mmesomachi Sylvia Mbaji, B.Pharm, Onyebuchi Oliver Offor, B.Pharm, Sunday Chibueze Ogbobe, B.Pharm and Abdulmuminu Isah, PhD
Article Type: Review Article | First Published: 2024/06/14
Human Papillomavirus (HPV) is the most prevalent sexually transmitted infection, posing a significant public health concern with HPV-associated oropharyngeal cancer emerging as the most common HPV-associated cancer (HPV-aOC). Risky sexual behaviours, notably, oral sex emerge as a critical risk factor for HPV-aOC. Despite its profound impact, there exists a poor awareness of the connection between HPV and oropharyngeal cancer, coupled with suboptimal vaccine uptake. By elucidating the nexus betwe...
Open Access DOI:10.23937/2469-5823/1510200
Promoting Health Literacy: Efficacy of an Obesity Focused Educational Intervention for Undergraduates
Cameron Carter, Maggie Nobles, Nicholas Castellucci, Matthew McCall, Fatma al-Dhefery and Amie J. Dirks-Naylor
Article Type: Original Research | First Published: 2024/06/10
Obesity is a progressive issue that affects 1 in 3 adults in the United States. Research shows that educational interventions can positively impact community knowledge levels and implementation of healthy lifestyle habits. Thus, the aim of this study was to determine the efficacy of an obesity focused interactive educational intervention on knowledge acquisition among undergraduate students. The correlation between personal exercise habits and baseline knowledge was also investigated....
Open Access DOI:10.23937/2377-9004/1410260
Uterine Malformations: Two Cases Report of Incidental Discovery during Emergency Caesarean Sections
Ouattara Adama, Ouédraogo Emmanuel, Kabore Yacouba, Traoré Salah Idriss and Ouédraogo Charlemagne Marie
Article Type: Case Report | First Published: 2024/05/31
Congenital malformations of the uterus vary in frequency according to studies throughout the world. They may be discovered antenatally, at birth or during childhood. Some remain unrecognised and are discovered later by chance during radiological investigations or surgery. We report two cases of uterine malformations, one case of a unicervical bicornuate uterus and one case of a unicornuate uterus discovered incidentally during emergency caesarean sections....
Open Access DOI:10.23937/2469-5807/1510151
Scrotal Calcinosis: A Comprehensive Case Report with Literature Review
Wit Tharanon, Narongsak Tang-on, Sarawoot Cherthong and Komson Wannasai
Article Type: Case Report | First Published: 2024/06/03
Idiopathic scrotal calcinosis is a benign disorder characterized by the deposition of calcium salts in the skin layers of the scrotum, leading to the formation of painless nodules. We present a 60-year-old Thai male patient diagnosed with idiopathic scrotal calcinosis. The patient presented with multiple hard nodules in the scrotal region, a characteristic finding of this rare condition. He did not report any associated symptoms, such as pain or discomfort. The diagnosis was confirmed through pa...
Open Access DOI:10.23937/2474-3631/1510040
Understanding Addiction: Insights from Research and Medicine
Kieran Poland, MbChBMRes and Patrick Davies, BMedSci BMB MRCPCH
Article Type: Research Article | First Published: 2024/06/06
Addiction, a multifaceted neurobiological disorder characterized by compulsive substance use despite negative consequences, poses significant challenges to public health worldwide. This paper presents a comprehensive examination of addiction research and medicine, delving into the intricate neurobiological mechanisms, current treatment modalities, and future prospects for intervention. By synthesizing existing knowledge and exploring emerging avenues of inquiry, this review aims to contribute to...