Open Access DOI:10.23937/2469-5807/1510154

The Role of Cell Cycle Division 6 (CDC6) in Cancer: Breast Cancer as a Prototype

Yousif A Kariri

Article Type: Review Article | First Published: 2024/07/08

An increase in cancer-cell division (proliferation) is a distinctive feature of cancer and is acknowledge as a key cell-division checkpoint alteration in cancer cells. Breast cancer is well-known as a heterogeneous disease with variant molecular subtypes, responses to therapy and morphological characteristics, breast malignant cells are identified to deactivate cell-cycle checkpoints to support survival and proliferation. Cell-cycle division 6 (CDC6) plays an important role as a cell-cycle check...

 Open Access DOI:10.23937/2378-3419/1410187

Plasma Cell Neoplasms with Atypical Features in a University Hospital

Everard Kylie R, MD, Zern Chantel, MD and Ikpatt Offiong Francis, MD

Article Type: Review/Case Series | First Published: 2024/07/08

Plasma cell neoplasms are derived from terminally differentiated B-cells. The distinction between anaplastic plasma cell myeloma and plasmablastic lymphoma, a B cell lymphoma, can be challenging. We present 3 cases of neoplasms with plasmacytic features that highlight the heterogeneity of plasma cell neoplasms and challenges in their diagnosis. Molecular profiling of these cases may provide value in their differential diagnosis....

 Open Access DOI:10.23937/2643-461X/1710077

Neonatal Anemia: Prevalence, Associated Factors, and Impact of Malaria in a Newborn Population at the University Hospital Center of Libreville

Minko J, Mbang Nguema OA, Moutombi Ditombi B, Lembet Mikolo AM, Ovengue FC, Mawili Mboumba DP, Ategbo SJ and Bouyou-Akotet MK

Article Type: Research Article | First Published: 2024/07/07

Demographic, clinical, and paraclinical variables of the newborns, as well as maternal histories were prospectively collected in 2015. A thick drop and a complete blood count were performed....

 Open Access DOI:10.23937/2469-5718/1510266

Increases in Upper-Body Strength are Dependent on Training Modality and Independent of Initial Strength Level and Fat-Free Mass Index in Women

Monica L Hunter, Jana L Arabas, Liz Jorn, Jerry L Mayhew and William F Brechue

Article Type: Research Article | First Published: 2024/07/07

Strength was determined from one-repetition maximum (1RM) free weight and modality specific upper-body press measured before and after 12 weeks of periodized RT with each modality. From a large cohort (N = 570), the top and bottom 20% were identified for one-repetition maximum bench press with free weights (FW, n = 60), seated horizontal press (SHP, n = 80), and supine vertical press (SVP, n = 87) for low (n = 94) or high (n = 133) FFMI (FFMI = FFM/Ht2) groups. RT also included upper- and lower-...

 Open Access DOI:10.23937/2474-3658/1510323

Knowledge, Attitudes, and Practices of Healthcare Students' Infection Control in COVID-19 Test Sampling in Vietnam: A Cross-Sectional Descriptive Study

Khanh Hoang Pham, Quyen Thi My Huynh, Ny Dang Tieu Tran, Phuong Truc Vo, Nhat Minh Phan, Tuong Manh Do, Thi Anh Nguyen, Karl Rennick-Zuefle and Tin Hoang Nguyen

Article Type: Research article | First Published: 2024/06/30

The Coronavirus Disease 2019 (COVID-19) pandemic became much more severe in 2021. Healthcare students were a crucial population that needs to participate in disease preventive assistance and were very susceptible to COVID-19 exposure due to the specialized nature of their area of study. Knowledge, attitudes, and practices were important for protecting healthcare volunteer students against infection in COVID-19 sampling....

 Open Access DOI:10.23937/2643-4474/1710162

Right Frontotemporal Meningioma Encasing a Middle Cerebral Artery Aneurysm, A Case Report and Review of the Literature

Razan Almufarriji, MD and Abdullah Alobaid, MD, FRCSC

Article Type: Case Report | First Published: 2024/07/06

Meningiomas encasing an aneurysm are considered one of the rare presentations encountered in neurosurgical services. To the best of our knowledge, this is the fourth case describing a frontotemporal meningioma encasing a middle cerebral artery aneurysm. Management of such cases has many aspects to consider and scenarios to be prepared for....

 Open Access DOI:10.23937/2643-4474/1710161

CNS Embryonal Tumour with Desmoplastic Reaction Treated with Ultra-NPT Bionanocatalysts

Tessy Lopez-Goerne, Francisco J Padilla-Godínez, Daniel Alvárez-Amador, Antonela Gonzalez-Bondani, Rafael Valiente, Fernando Chico Ponce de Leon, Vicente Gonzalez-Carranza and José Omar Navarro-Fernández

Article Type: Case Report | First Published: 2024/07/06

Central nervous system (CNS) embryonal tumors, lacking a distinct molecular signature and categorized as "Not Otherwise Specified (NOS)", are WHO grade IV neoplasms with significant genetic diversity. They typically exhibit immature cell sheets with round, oval, or angulated nuclei, often located supratentorially and characterized by a desmoplastic reaction. Diagnosis relies on MRI and molecular analysis, with traditional management involving surgery, radiotherapy, and chemotherapy. However, rec...

 Open Access DOI:10.23937/2474-1353/1510163

An Experience of Use of Zuspan Regimen for Severe Preeclampsia and Eclampsia at a University Hospital

Girija S, Manjunath AP, Vanita P, Al Dughaishi T, Al Riyami N and Suhas AM

Article Type: Original Article | First Published: 2024/06/30

Preeclampsia and eclampsia remain major contributors to maternal morbidity and mortality worldwide. Magnesium sulfate (MgSO4) is a key treatment in managing these conditions. This study evaluates the outcomes of intravenous MgSO4 therapy in women with preeclampsia and eclampsia at a tertiary care university hospital in Oman....

 Open Access DOI:10.23937/2474-1353/1510162

Longitudinal Analysis of Heart Rate Variability in Post-Bariatric Pregnant Woman: A Case Report

Renata da Silva Cardoso Rocha Tavares, PhD, Tatiana Sousa Cunha, PhD and Karina Rabello Casali, PhD

Article Type: Case Report | First Published: 2024/06/30

The measurement of heart rate variability (HRV) allows a noninvasive investigation of the functioning of the autonomic nervous system, especially the balance between sympathetic and vagal activity. Pregnancy after bariatric surgery has some peculiarities that may interfere with its course and evolution. Studies have investigated the variability of maternal heart rate and its relationship to the prognosis for pregnancy development about the risks of eclampsia and pregnancy complications. This pap...

 Open Access DOI:10.23937/2474-3658/1510322

Correlation of Ultrasonographic Findings of the Kidneys to Serum Creatinine Levels in Lassa Fever Patients in a Tertiary Health Facility in Sub-Saharan Africa

Oriaifo BB, Adeyekun AA, Irabor PI, Okokhere PO, Izevbekhai SO

Article Type: Original Research | First Published: 2024/06/30

Lassa fever is an acute viral haemorrhagic fever that affects all major organs of the body including the kidneys. Renal complications of this disease are an important cause of morbidity and mortality in affected patients. Early detection of renal involvement will facilitate the initiation of measures to improve the clinical outcome of such patients as treatment is more effective if initiated early. Ultrasonography is a valuable imaging modality in the evaluation of the kidneys and is useful in a...