Open Access DOI:10.23937/2377-3634/1410147
Clinical Characteristics and Outcome of COVID-19 among People Living with Diabetes in Nigeria
Vivian Gga Kwaghe, Rifkatu Reng, Olufemi Adediran and Felicia Anumah
Article Type: Original Article | First Published: August 28, 2021
The novel coronavirus disease 2019 (COVID-19) has affected millions of people globally with over 3 million deaths. People with underlying comorbidities are at a risk of having severe disease with increased fatality. This study aimed at describing the clinical characteristics and outcome of COVID-19 among people living with diabetes mellitus (DM) in Nigeria. This was a retrospective study that analyzed the data of adult patients who were admitted into the isolation and treatment center at the Uni...
Open Access DOI:10.23937/2378-3419/1410159
Total Maxillectomy in Children: A Report Two Cases
Agustina Lorea, Eduardo Figueroa, Juan Larrañaga and Carlos S Ruggeri
Article Type: Case Report | First Published: September 08, 2021
We describe the clinical cases of two pediatric patients who were treated with a total maxillectomy and chemo/ radiotherapy for suffering from malignant tumors of the maxilla. The reconstruction of the floor of the orbit was done with titanium micromesh and the defect in the maxilla and hard palate was reconstructed with free flaps. This allowed a quick swallowing rehabilitation and an excellent cosmetic result. Total maxillectomy is a surgical technique that involves the resection of all the bo...
Open Access DOI:10.23937/2378-3419/1410158
Proposed Biology of the Spontaneous Remission of Cancer
Behzad Niakan
Article Type: Hypotheses | First Published: September 08, 2021
Two common factors were identified among the case reports of the prolonged spontaneous remission and regression of cancer. The prolonged spontaneous remissions of cancer may be preceded by a low blood oxygen delivery to the tumor and a short, steady or rapid malignant growth. The steady or rapid growth of primary tumor not the growth of new metastases. Case reports of the spontaneous disappearance of verified cancer without any medical intervention has baffled researcher. The disappearance of al...
Open Access DOI:10.23937/2378-3419/1410156
Atypical Presentation of Triple-Negative Breast Cancer
Ramon Eduardo Garcia-Cahuich, Felipe Rodríguez-Solis, Nancy E. García-Carrillo, Alondra Yereldi Naranjo-Cruz, Lorena Berenice Hernández-Hoil and María Valeria Jiménez-Báez
Article Type: Case Report and Systematic Review | First Published: August 30, 2021
Triple-Negative Breast Cancer (BCTN) has been defined as the absence of Estrogenic Receptors (ER), Progesterone Receptors (EP), Epidermal growth factor receptor 2 (HER2), and it conforms 10 to 20% of all cases of breast cancer. A 42-years-old female, debuting with abdominal pain, a 44 pounds of weight loss on the last 2 months and abdominal mass presence. A single complex looking nodule found in the left breast, which underwent a biopsy with results of triple negative breast adenocarcinoma, she ...
Open Access DOI:10.23937/2378-2951/1410236
An Electrocardiographic Early Repolarization Pattern in a Competitive Athlete: Is it a Sign of Danger?
Daniel B Petrov, MD, FESC and Yoana D Petrova, M. Pharm
Article Type: Case Report | First Published: September 06, 2021
The 12-leads electrocardiogram (ECG), can play a key role in the diagnosis of ERP, and many pre-participation screening protocols include an ECG, because is it a simple, inexpensive initial tool in the evaluation a both symptomatic and asymptomatic athletes. In the setting of pre-participation screening appropriate differential diagnosis between physiologic and pathologic ST-segment elevation is of importance not only to prevent sport related sudden cardiac deaths (SCD), but also to avoid unnece...
Open Access DOI:10.23937/2378-2951/1410235
Appropriate Use and Outcomes of In-Hospital Telemetry: Implications Regarding the Contemporary Code Blue
Ronald F Espinosa, DO, Christopher A Woolley II, MD, Scot W Nolan, DNP, RN, Jill M Waalen, MD, MPH and Bruce J Kimura, MD, FACC
Article Type: Retrospective Cohort | First Published: September 03, 2021
Although practice standards for telemetry reflect the historical benefit of early monitoring for arrhythmias in select admissions, few data exist on the initial appropriateness of telemetry for contemporary inpatients who then later suffered a “code blue.” As telemetry monitoring is a significant resource, we sought to review appropriate use, detection of causative arrhythmias, and the timing and outcomes of telemetry use in code blues. Over a 3-year period in a 300-bed teaching hospital, da...
Open Access DOI:10.23937/2469-5696/1410067
SMYD2 in Leukemia: An Update
Teresa Rubio-Tomás
Article Type: Mini-Review Article | First Published: August 30, 2021
SMYD2 is one of the five members (SMYD1-5) of the Su(Var)3-9, Enhancer-of-zeste and Trithorax (SET) and Myeloid, Nervy, and DEAF-1 (MYND) domain-containing (SMYD) protein family and is it known to methylate histone and non-histone substrates. By methylating a wide range of targets, SMYD2 acts as an oncogene in most cancer types. In this review I will comment on the last publications related to the role of SMYD2 in leukemia and I will refer to more extensive reviews if the reader aims to have a b...
Open Access DOI:10.23937/2469-5696/1410066
Hypogonadotropic Hypogonadism in a Female Patient with Thalassemia Major
Richmond R Gomes
Article Type: Review Article | First Published: August 28, 2021
Thalassemia refers to a group of inherited diseases characterized by decreased or absent synthesis of normal globin chains. The direct consequence is an imbalance of the alpha and beta globin chain synthesis that results in anemia from ineffective erythropoiesis and hemolysis. The term thalassemia major refers to the severe form that is often associated with life-long transfusion dependent anemia. Hypogonadism is the most frequently reported endocrine complication, affecting 70-80% of thalassemi...
Open Access DOI:10.23937/2377-4630/1410126
Epidural Blood Patch for Spontaneous Intracranial Hypotension
Li Weiling Lydia, MBBS, MMed, Lim Yiqi Ofelia, MBBS, Chan Lijuan Jasmine, BMed/MD and Alex Joseph, MBBS, MD, FRCA
Article Type: Case Report | First Published: September 05, 2021
Spontaneous intracranial hypotension (SIH) is uncommon and postulated to occur due to spontaneous cerebrospinal fluid (CSF) leak. Subdural hemorrhage is a rare but serious complication of intracranial hypotension. With a paucity of high-level evidence to guide treatment, its management remains challenging. We report a case of spontaneous intracranial hypotension which was successfully treated with an epidural blood patch. The patient is a 59-year-old man with poorly controlled diabetes and hyper...