Open Access DOI:10.23937/2378-3397/1410137

Impact of Neoadjuvant Chemotherapy Interval on Tumour Regression Grading for Rectal Cancer

Thomas Tiang, MBBS, FRACS, Ankur Sidhu, MBBS, FRACS, David Williams, MBBS, FRCPA and Andrew Bui, MBBS, FRACS

Article Type: Research Article | First Published: January 30, 2022

The rectum is the site of 30% of all colorectal tumours. When contemplating neoadjuvant alternatives and surgical treatments, the rectum’s position within the bony pelvis and its closeness to important tissues offer major therapeutic difficulties. Colorectal cancer survival times have improved as a result of advances in primary and adjuvant treatments. This paper aims to investigate the tumour regression grade (TRG) in rectal cancer patients, primarily if the interval of surgery after neoadjuv...

 Open Access DOI:10.23937/2378-3516/1410169

Evaluation of Patient Outcomes of High Flow versus Low Flow Nasal Oxygen during Outpatient Bronchoscopy under Conscious Sedation at Thoracic Procedure Suite in Lyell McEwin Hospital

Singankutti Mudalige Thanuja Nilushi Priyangika, Moayed Alawami and Shanka Karunarathne

Article Type: Original Research | First Published: February 05, 2022

High flow nasal oxygen (HFNO) has been shown to reduce desaturations during flexible bronchoscopy. We evaluated outcomes of HFNO vs. low flow nasal oxygen (LFNO) on intraprocedural hypoxemia, the demand of sedative and reversal medications, postprocedure complications, procedure conversion to general anaesthesia and patient comfort during outpatient standard and EBUS (Endo Bronchial Ultrasound) guided bronchoscopy under conscious sedation. A Prospective open-label study where the first 42 patien...

 Open Access DOI:10.23937/2469-5769/1510087

Newborn Resuscitation Scale Up and Retention Program Associated with Improved Neonatal Outcomes in Western Nepal

Naresh Pratap KC, Ranjan Dhungana, Emily Gamboa, Siena F Davis, Michael K Visick and Robert B Clark, MD, MPH

Article Type: Original Article | First Published: February 07, 2022

The adoption of Helping Babies Breathe (HBB) tool has improved the outcomes of neonatal resuscitation following intrapartum events. Perinatal asphyxia however remains a leading cause of neonatal morbidity and mortality in Nepal. HBB training has proven effective, but a major challenge is maintaining resuscitation skills over time. Safa Sanaulo Nepal (SSN) designed an evidence-based strategy for scaling up training and sustaining long-term retention. This paper describes the implementation of SSN...

 Open Access DOI:10.23937/2643-4563/1710035

Relationship between Awareness of Healthy Lifestyle and Perception of Breast Cancer among Women of Reproductive Age

Yeliz VARIŞOĞLU, PhD and Pınar IRMAK VURAL, PhD

Article Type: Original Article | First Published: January 31, 2022

The aim of this study was to determine the relationship between awareness of healthy lifestyle and breast cancer perception among women of reproductive age. This descriptive co relational study was conducted on 642 women. Data were collected using the sociodemographic data form, the Healthy Lifestyle Awareness Scale (HLAS), and the Breast Cancer Perception Scale (BCPS). A moderate, significant, and positive correlation was found between the HLAS total score and the scores obtained from the BCPS ...

 Open Access DOI:10.23937/2643-4563/1710033

Prognostic Utility of Targeted Circulating Cell-Free DNA versus Formalin-Fixed Paraffin-Embedded DNA Mutation Analysis for Advanced Lung Cancer

Madli Tamm, Mart Kals, Tarmo Annilo, Kersti Oselin, Katrin Keerma, Paula Ann Kivistik, Miriam Nurm, Margot Saare, Jana Jaal and Neeme Tõnisson

Article Type: Original Article | First Published: January 23, 2022

Cancer burden is a globally growing problem. Early diagnosis and targeted treatment decrease patients’ death rate, pain, and treatment expenses. Liquid biopsy can be used for early cancer detection, treatment selection, and progression and treatment response monitoring. We evaluated the performance of circulating cell-free DNA (cfDNA) and formalin-fixed paraffin-embedded (FFPE) tissue DNA analyses using a commonly employed targeted therapeutic pathway in predicting the outcomes of patients wit...

 Open Access DOI:10.23937/2378-3664.1410036

Encapsulation of Alendronate in Chitosan based Polymeric Nanoparticles for Effective Management of Osteoporosis - Development to Release Kinetic Study

Sandhya Pathak, Satyendra Kumar Tripathi, Chandni Pachouri and Archna Pandey

Article Type: Research Article | First Published: January 31, 2022

Osteoporosis means "Porous bone” is a disease characterized by progressive bone thinning. The deterioration of bone tissue can lead to bone fragility and fracture, especially of the hip, spine, shoulder and wrist. Osteoporosis is characterized by decreasing bone mineral density (BMD). Bisphosphonates are the most commonly prescribed drugs for the treatment of osteoporosis in the US and many other countries including India. Alendronate (Aln) is a widely used anti-osteoporosis drug, exhibits str...

 Open Access DOI:10.23937/2643-4059/1710028

Anxiety Symptomatology and Patterns of Coping amongst Medical Doctors and Nurses in Nigeria during the COVID-19 Pandemic: An Online Cross-Sectional Survey

Seb-Akahomen Omonefe J, Okogbenin Esther O, Obagaye Olukunle M, Erohubie Paul O and Aweh Benjamin E

Article Type: Research Article | First Published: December 31, 2021

The unprecedented global crisis triggered by the COVID-19 pandemic led to a cascade of overwhelming pressure on the healthcare system. Frontline healthcare professionals (HCPs), especially doctors and nurses were confronted with an increased risk of mental disorders, most commonly identified are anxiety disorders. This study aimed to determine the prevalence of anxiety symptomatology amongst doctors and nurses in Nigeria and the effects of the coping pattern of participants on the symptoms of an...

 Open Access DOI:10.23937/2474-3674/1510137

Effectiveness of a Protective Ventilatory Strategy Using Prone Decubitus in Patients with Severe Acute Respiratory Syndrome (SARS) after Covid-19: Integrate Review

Daniela Alves de Moraes Ribeiro and Fabrício Vieira Cavalcante

Article Type: Review Article | First Published: February 05, 2022

The main objective of the present study is to investigate the effectiveness of the ventilatory strategy in decubitus in the prone position in patients with severe acute respiratory syndrome triggered by Covid-19. This is an integrative literature review combined with the snowball technique, based on the following question: “What are the effects of the protective ventilatory strategy in prone decubitus in patients with SARS secondary to Covid-19? PUBMED and Academic Google were used as database...

 Open Access DOI:10.23937/2690-263X/1710012

Predictive Role of Duration of Treatment, Social Anxiety in Self-Efficacy to Resist Alcohol among Persons with Alcohol Use Disorder in Ghana

Marie Pearl Agordzo, Joseph Kwarteng Ofosuhene-Mensah, Kofi Krafona and George Ekem-Ferguson

Article Type: Research Article | First Published: February 07, 2021

Self-efficacy to resist alcohol use is necessary to prevent relapse after treatment. However, the duration of patients stay in treatment and social anxiety are crucial in treatment outcomes of patients but its predictive role in selfefficacy to resist alcohol in the Ghanaian context is yet to be known. Sixty participants obtained through purposive sampling participated in the study. These participants were patients with an established diagnosis for alcohol use disorder within the three main publ...

 Open Access DOI:10.23937/2643-3966/1710038

Technical Feasibility Does Not Guarantee Clinical Improvement: A Word of Caution for Valve-in-Valve Procedures in Small Surgical Prosthesis

Marie-Elisabeth Stelzmueller, Bruno Mora, Guenther Laufer and Wilfried Wisser

Article Type: Case Report | First Published: March 13, 2021

The reoperation of old and frail patients with small tissue valves is a still challenging topic in cardiac surgery. An 85-years-old patient who underwent an aortic valve replacement (AVR) with a Mitroflow 21 mm and single coronary bypass operation 6 years ago, presented again dyspnea NYHA II-III. The echo showed a restenosis of the tissue valve and a mean gradient of 40 mmHg. Because of age, frailty and calculated perioperative risk, the patient was evaluated for a transcatheter valve-in-valve i...