Open Access DOI:10.23937/2469-5807/1510137
Do Messenger RNA Vaccines Induce Pathological Syncytia?
Adonis Sfera, MD, Karina G Thomas, DAN O Sfera, Jonathan J Anton, Christina V Andronescu, Nyla Jafri, Sarvin Sasannia and Zisis Kozlakidis
Article Type: Review Article | First Published: October 20, 2022
The Pfizer and Moderna COVID-19 vaccines are composed of lipid nanoparticles (LNP) containing a modified messenger RNA (mRNA) that encodes for the Spike S protein. The LNP transfection likely involves particle engulfment by the host immune cells due to their resemblance to apoptotic bodies, vesicles with externalized phosphatidylserine (ePS). As the LNPs are decorated with PS-like ionizable phospholipids, including 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), they encourage human phagocyte...
Open Access DOI:10.23937/2377-9004/1410230
Diapers and Dialysis: A Case Report on Postpartum Atypical Hemolytic Uremic Syndrome
Meghan St John, MD and Maritsa Scoulos-Hanson, DO
Article Type: Case Report | First Published: October 19, 2022
While thrombotic microangiopathy (TMA) syndromes such as thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS) and atypical hemolytic uremic syndrome (aHUS) present similarly with hemolytic anemia, thrombocytopenia, and renal injury, their etiology and treatment differs. This poses challenges to prompt diagnosis and treatment....
Open Access DOI:10.23937/2377-9004/1410229
Abortion in Patient with Obstructive Longitudinal Vaginal Adhesion following Vaginal Prolapse Surgery: A Case Report
Arielle W Fein, MD, Madeline A Dick-Biascoechea, MD, Gracie Nichols, CRNP and Jessica K Lee, MD, MPH
Article Type: Case Report | First Published: October 12, 2022
A vaginal adhesion is an uncommon complication of vaginal surgery. While treatment options for radiation- induced vaginal stenosis and vaginal septum have been well-characterized, there is little to guide surgeons providing care to patients with intravaginal adhesions. This report presents a multigravida with history of anterior and posterior colporrhaphy and perineoplasty referred from an outpatient abortion clinic for a dense longitudinal adhesion obstructing the cervix....
Open Access DOI:10.23937/2643-4474/1710123
Case Report: Use of MLC601 in Severe Traumatic Brain Injury
Ramesh Kumar, Peh Hong Shawn and Narayanaswamy Venketasubramanian
Article Type: Case Report | First Published: October 14, 2022
Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. The medical management of TBI involves stabilization of the individual and focusing on preventing further injury. There are no proven pharmacological therapies to enhance recovery after severe TBI....
Open Access DOI:10.23937/2474-3690/1510070
Isolated Systolic Hypertension in Young Patients
Minetto Julian
Article Type: Review Article | First Published: October 01, 2022
The international society of hypertension, like other societies, defines isolated systolic hypertension (ISAH) as a brachial arterial pressure value greater than 140 mmHg of systolic values and less than 90 mmHg of diastolic values....
Open Access DOI:10.23937/2469-5793/1510150
Challenges Imposed by Online-Based Learning on Acquiring Clinical Knowledge and Skills
Firdous Jahan, Mohammed Al Azri, Arwa Hilal Salim Al Azri, Laila Alwahaibi and Muhammad Siddiqui
Article Type: Research Article | First Published: October 02, 2022
Medical students in clinical years are supposed to be independent, self-directed learner to motivate in depth learning. In response to COVID-19, medical education faculty have quickly transitioned to online formats that include COVID-19 crisis. The main purpose of this study was to assess the experience of clinical years’ students with online-based learning during the COVID19 pandemic....
Open Access DOI:10.23937/2469-5750/1510116
Short Course Treatment with Dapsone in a 59-Year-Old Male with Dermatitis Herpetiformis: A Case Report
Zacaria B Pario Jr, MD and Victoria P Guillano, MD
Article Type: Review Article | First Published: October 12, 2022
Dermatitis Herpetiformis is a chronic autoimmune blistering skin condition that is often associated with gluten-sensitive enteropathy. The primary lesion of DH is an erythematous papule, plaque, or, most commonly, a vesicle that can be pruritic. Most DH patients have an associated GI abnormality and a higher incidence of other autoimmune diseases, such as thyroid disease, insulin- dependent diabetes, lupus erythematosus, and vitiligo. In 70% of cases, patient with DH will require dapsone after...