Aksoy RT, Çınar M, Tokmak A, Özkaya E, Güzel AI, et al. (2018) Handedness Score in Unexplained Infertility, a Contribution to the Debate on Neuronal Function in Fertility. Reprod Med Int 1:007.


© 2018 Aksoy RT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ORIGINAL ARTICLE | OPEN ACCESS DOI: 10.23937/rmi-2017/1710007

Handedness Score in Unexplained Infertility, a Contribution to the Debate on Neuronal Function in Fertility

Rıfat Taner Aksoy1, Mehmet Çınar1, Aytekin Tokmak1*, Enis Özkaya2, Ali İrfan Güzel1 and Nafiye Yılmaz1

1Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey

2Department of Obstetrics and Gynecology, Zeynep Kamil Women's and Children's Disease Training and Research Hospital, İstanbul, Turkey



The aim of this study was to assess the value of handedness score as an indicator of neuronal function in predicting unexplained infertility (UI).


Fifty female patients with UI, 50 male patients with UI, 50 fertile female controls and 50 fertile male controls were evaluated in terms of handedness score obtained by using Edinburgh Handedness Inventory. Association between the score and the UI cases was assessed.


Mean age of the female study population was 27.1 ± 3.4 years. Groups were comparable in terms of left/right handedness (12/38 vs. 15/35, p = 0.499). However comparison of mean handedness scores between the groups revealed a significant difference (64.6 vs. 74.2, p < 0.001). Handedness score was a significant predictor of UI among women patients (AUC = 0.749, p < 0.001). Optimal cut off value was obtained at a level of 72.5 with 80% sensitivity and 60% specificity. On the other hand, fertile and infertile male groups were comparable regarding left/right handedness (9/41 vs. 14/36 p = 0.235). Comparison of scores between groups revealed similar results (72.4 vs. 71.2, p = 0.663).


After screening for all the fertility diagnostic tests, handedness score that indirectly show the neuronal cascade function associated with the fertility problems may be used to confirm real UI in women.