Elkhoudri N, Marhoume FZ, Amor H, Baali A (2019) Serum Transaminases Elevations to Predict Adverse Outcomes of Preeclampsia. Obstet Gynecol Cases Rev 6:148.


© 2019 Savescu A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

RESEARCH ARTICLE | OPEN ACCESSDOI: 10.23937/2377-9004/1410148

Serum Transaminases Elevations to Predict Adverse Outcomes of Preeclampsia

Elkhoudri N1,2*, Fatima Zahra Marhoume2, Amor H1 and Baali A1

1Department of Biology, Laboratory of Human Ecology, School of Sciences Semlalia, Cadi Ayyad University, Marrakesh, Morocco

2Mohammed VI University Hospital, Marrakesh, Morocco



The aim of this study is to evaluate the transaminases capacity in predicting the adverse outcomes of preeclampsia.


This study was carried out among women hospitalized in Department of Obstetrics and Gynecology and intensive care unit at maternity university hospital between January 2013 and June 2015. We have compared the group of eclampsia with preeclampsia control group, each case (eclamptic woman) was matched to a control (preeclamptic woman), a ratio of 1/1. Transaminases levels were compared in the two groups (cases and controls).


58 cases of eclampsia were observed during the study period, corresponding to a rate of 7.9 per 10,000 births. Transaminases levels were higher among eclamptic women compared to women with preeclampsia, respectively 107.10 U/L and 28.2 U/L for ALT, and 171.75 U/L and 30.12 U/L for AST (p = 0.01 and p = 0.008).

ALT area under the ROC curve was 0.718 (CI 95%: 0.62-0.81). For a sensitivity of 74% and a specificity of 66%, the best threshold value was 57 U/L. While for AST the area under the ROC curve was 0.716 (CI 95%: 0.61-0.82), the best threshold value was 59 U/l, with a sensitivity of 76% and a specificity of 57%.


Transaminases levels were significantly higher during eclampsia compared with preeclampsia. This is a clinically useful way to predict the adverse outcomes of preeclampsia. However, a prospective study is necessary to develop a clinical prediction model of eclampsia.