Leiomyomas or fibroids are the most common benign tumor of uterus and it often increases in size during pregnancy. Its incidence in pregnancy is approximately 1.5-2% and is associated with increased risk of complication during pregnancy including abortions, preterm labor, red degeneration, malpresentations, increased cesarean section rates, postpartum hemorrhage. We hereby, discuss a case of large multi-lobed uterine fibroid complicating the second trimester of pregnancy. Our patient presented with a large leiomyoma of approximately 28 × 30 cm size at 28 weeks of gestation with acute red degeneration of fibroid with intra-capsular and intra-peritoneal bleed. Life saving subtotal hysterectomy was done and around 1.5-2 liters of blood was drained out from the abdominal cavity. The total weight of uterus with fibroid was around 15 kg and benign leiomyoma was confirmed on histopathological examination.