Clear cell renal cell carcinoma (ccRCC) is a malignant entity that develops from the renal tubular epithelium. piR-36707 and piR-36741 have not previously been associated with ccRCC and their potential roles in the pathogenesis of ccRCC are mystery.
In the present study, formalin-fixed paraffin embedded (FFPE) specimens were obtained from 19 patients having ccRCC diagnosis. Then, the expression levels of piR-36707 and piR-36741 were analyzed by Real-Time PCR with respect to clinical parameters.
The expression levels of piR-36707 and piR-36741 were found higher in tumor samples than control ones. Also, piR-36707 expression showed significantly different pattern in terms of gender. Moreover, piR-36707 and piR-36741 expressions displayed statistically significant difference with respect to some TNM staging comparisons. piR-36707 and piR-36741 expressions were significantly differed between Fuhrman nuclear grade 2 and 4. Furthermore, piR-36741 expression change was significantly associated with the changes between low and normal RBC counts of ccRCC patients. Similarly, piR-36707 expression was significantly associated with hemoglobin count change of ccRCC patients.
According to the literature, this is the first study that relates ccRCC pathogenesis with piR-36707 and piR-36741. Prospectively, all genes in target of piR-36707 and piR-36741 should be studied for the pathogenesis of ccRCC.