Heng C (2019) Stress Fractures in Loeys-Dietz Syndrome. Int Arch Orthop Surg 2:008.


© 2019 Heng C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

CASE REPORT | OPEN ACCESS DOI: 10.23937/2643-4016/1710008

Stress Fractures in Loeys-Dietz Syndrome

Christian Heng*

Department of Orthopedic Surgery, Singapore General Hospital, Academia, Level 4 College Road, Singapore


Loeys-Dietz Syndrome (LDS) is a rare autosomal dominant connective tissue disorder. Patients with this disorder have mutations in several genes which encode for Transforming Growth Factor-Beta Receptor. This genetic mutation causes patients to have low bone mineral density, usually resulting in osteoporotic-like fractures. Stress fractures are rarely reported in patients with LDS. We report a case of stress fracture in a patient with LDS, discuss the management of this patient and provide a brief overview of LDS.