A systematic review on diabetes care was centered in their modifying effects of coaching and motivational interventions on diabetes and hypertension care. Critical issues pertaining to the dose-response relationship between the intervention program and outcomes, the cost-effectiveness evaluation, and the lengths of observation were noted. A positive impact of health coaching (HC) and motivational intervension (MI) was noted in this review of randomized controlled studies. However, successful results are dependent on many factors such as the type of the program, the ethnicity or racial composition coupled with cultural sensitivity, the training of the healthcare providers who will execute the program, and the characteristics of the patients who are involved in the program. Specific recommendations were made for future clinical trial studies, using health coaching (HC) and motivational interview (MI) approaches.