The incidence of thyroid cancer has increased in recent years. This increase may be due to the change of metabolic parameters in patients. This study was designed to clarify the association of malignancy of thyroid nodules with metabolic parameters.
This study designed as a cross-sectional study between January 2018 and May 2018. Samples were collected from the patients by thyroid fine needle biopsy and patients who had thyroid surgery. Group 1 patients were pathologically benign patients; Group 2 patients were pathologically malignant. In both groups, preoperative TSH, fasting insulin were measured and HOMA-IR calculated. Statistical analysis was performed.
A total of 84 patients were included in the study. The benign group was 41 (F/M: 33/8) and the malignant group was 43 (F/M: 36/7). TSH levels (1.44 (0.0-9.4) versus 0.41 (0.0-8.9); p < 0.01), fasting insulin levels (13.0 (5.0-40.0) versus 9.4 (3.2-25); p < 0.05) and HOMA-IR levels (2.75 (1.06-13.19) versus 2.24 (0.68-6.3); p < 0.05) were significantly higher in the malignant group.
TSH elevation and insulin resistance may be associated with a risk of malignancyof thyroid nodule.