Join Us | Latest Articles | Contact

Journal Home


Editorial Board


Recent Articles


Submit to this journal


Special Issues


Current issue

Clinical Medical Image Library




Clinical and Radiographic Characteristics of Hereditary Gingival Fibromatosis

Jing Qiao, Feng Liu and Zu-Yan Zhang*



The First Outpatient Center, School and Hospital of Stomatology, Peking University, China


*Corresponding author: Zu-Yan Zhang, The First Outpatient Center, School and Hospital of Stomatology, Peking University, 100034 Xishenku Avenue Jia 37, Xicheng District, Beijing, China, Tel: 86-10-53295009, Fax: 86-10-62174226, E-mail: zhangzy-bj@vip.sina.com
Clin Med Img Lib, CMIL-2-035, (Volume 2, Issue 3); ISSN: 2474-3682
Published Date: March 24, 2016
Citation: Qiao J, Liu F, Zu-Yan Z (2016) Clinical and Radiographic Characteristics of Hereditary Gingival Fibromatosis. Clin Med Img Lib 2:035.
Copyright: © 2016 Qiao J, et al. This is an open-access content distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Hereditary gingival fibromatosis, also known as congenital familial fibromatosis or idiopathic fibromatosis, is a rare genetic disorder with prevalence of 1/750000 [1,2]. This disorder may show as an isolated disease entity or as part of a syndrome [3,4]. As a single disease entity, it is typically transmitted as an autosomal dominant trait [5]. The main clinical features of hereditary gingival fibromatosis include severe generalized and progressive gingival overgrowth [6,7]. It can involve attachment gingiva, marginal gingiva and interdental gingival papilla, which always cover the teeth partially or completely. Gingiva are smooth, firm and usually normal in color. This disease usually appears during childhood and occasionally delays eruption of teeth [8,9]. The body and mental development of patients are normal [10]. The most important treatment for hereditary gingival fibromatosis is dental plaque control and elimination of gingival inflammation [11,12]. Gingivectomy is usually performed after adolescence [13].

We show a 12-year-old Chinese girl in this report. She has obvious gingival overgrowth since her birth. Her father (42-year-old) and his ancestors all had similar status. The girl's intraoral image is shown in Figure 1. Figure 2 shows her panoramic radiograph. Her father's intraoral image is shown in Figure 3.


Informed Consent

An informed consent was obtained from the girl and her father.



Figure 1: Intraoral image of the patient



Figure 2: Panoramic radiograph of the patient.



Figure 3: Intraoral image of her father.




References
  1. Pappachan B, Narayan JV, Nayak A (2002) Idiopathic gingival fibromatosis: A neglected case. Indian J Radiol Imaging 12: 335-338.

  2. (2013) Hereditary gingival fibromatosis. Orphanet.

  3. Tay YK, Bellus G, Weston W (2001) What syndrome is this? Gingival fibromatosis-hypertrichosis syndrome. Pediatr Dermatol 18: 534-536.

  4. Bittencourt LP, Campos V, Moliterno LF, Ribeiro DP, Sampaio RK (2000) Hereditary gingival fibromatosis: review of the literature and a case report. Quintessence Int 31: 415-418.

  5. Hart TC, Zhang Y, Gorry MC, Hart PS, Cooper M, et al. (2002) A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1. Am J Hum Genet 70: 943-954.

  6. Ramer M, Marrone J, Stahl B, Burakoff R (1996) Hereditary gingival fibromatosis: identification, treatment, control. J Am Dent Assoc 127: 493-495.

  7. Millet C, Rodier P, Farges JC, Labert N, Duprez JP (2012) Surgical and prosthetic treatment in an elderly patient affected by unilateral idiopathic gingival fibromatosis: a case report. Gerodontology 29: e1185-1189.

  8. Kavvadia K, Pepelassi E, Alexandridis C, Arkadopoulou A, Polyzois G, et al. (2005) Gingival fibromatosis and significant tooth eruption delay in an 11-year-old male: a 30-month follow-up. Int J Paediatr Dent 15: 294-302.

  9. Hakkinen L, Csiszar A (2007) Hereditary gingival fibromatosis: characteristics and novel putative pathogenic mechanisms. J Dent Res 86: 25-34.

  10. Gawron K, Lazarz-Bartyzel K, Chomyszyn-Gajewska M (2014) Clinical presentation and management of a rare case of unilateral idiopathic gingival fibromatosis. Dent Med Probl 51: 546-552.

  11. Shetty AK, Shah HJ, Patil MA, Jhota KN (2010) Idiopathic gingival enlargement and its management. J Indian Soc Periodontol 14: 263-265.

  12. Bozzo L, de Almedia OP, Scully C, Aldred MJ (1994) Hereditary gingival fibromatosis. Report of an extensive four-generation pedigree. Oral Surg Oral Med Oral Pathol 78: 452-454.

  13. Tripathi AK, Dete G, Saimbi CS, Kumar V (2015) Management of hereditary gingival fibromatosis: A 2 years follow-up case report. J Indian Soc Periodontol 19: 342-344.


International Journal of Anesthetics and Anesthesiology (ISSN: 2377-4630)
International Journal of Blood Research and Disorders   (ISSN: 2469-5696)
International Journal of Brain Disorders and Treatment (ISSN: 2469-5866)
International Journal of Cancer and Clinical Research (ISSN: 2378-3419)
International Journal of Clinical Cardiology (ISSN: 2469-5696)
Journal of Clinical Gastroenterology and Treatment (ISSN: 2469-584X)
Clinical Medical Reviews and Case Reports (ISSN: 2378-3656)
Journal of Dermatology Research and Therapy (ISSN: 2469-5750)
International Journal of Diabetes and Clinical Research (ISSN: 2377-3634)
Journal of Family Medicine and Disease Prevention (ISSN: 2469-5793)
Journal of Genetics and Genome Research (ISSN: 2378-3648)
Journal of Geriatric Medicine and Gerontology (ISSN: 2469-5858)
International Journal of Immunology and Immunotherapy (ISSN: 2378-3672)
International Journal of Medical Nano Research (ISSN: 2378-3664)
International Journal of Neurology and Neurotherapy (ISSN: 2378-3001)
International Archives of Nursing and Health Care (ISSN: 2469-5823)
International Journal of Ophthalmology and Clinical Research (ISSN: 2378-346X)
International Journal of Oral and Dental Health (ISSN: 2469-5734)
International Journal of Pathology and Clinical Research (ISSN: 2469-5807)
International Journal of Pediatric Research (ISSN: 2469-5769)
International Journal of Respiratory and Pulmonary Medicine (ISSN: 2378-3516)
Journal of Rheumatic Diseases and Treatment (ISSN: 2469-5726)
International Journal of Sports and Exercise Medicine (ISSN: 2469-5718)
International Journal of Stem Cell Research & Therapy (ISSN: 2469-570X)
International Journal of Surgery Research and Practice (ISSN: 2378-3397)
Trauma Cases and Reviews (ISSN: 2469-5777)
International Archives of Urology and Complications (ISSN: 2469-5742)
International Journal of Virology and AIDS (ISSN: 2469-567X)
More Journals

Contact Us

ClinMed International Library | Science Resource Online LLC
3511 Silverside Road, Suite 105, Wilmington, DE 19810, USA
Email: contact@clinmedlib.org
 

Feedback

Get Email alerts
 
Creative Commons License
Open Access
by ClinMed International Library is licensed under a Creative Commons Attribution 4.0 International License based on a work at https://clinmedjournals.org/.
Copyright © 2017 ClinMed International Library. All Rights Reserved.