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Clinical Medical Image Library

Clinical and Radiographic Characteristics of Hereditary Gingival Fibromatosis

Jing Qiao, Feng Liu and Zu-Yan Zhang*

The First Outpatient Center, School and Hospital of Stomatology, Peking University, China

*Corresponding author: Zu-Yan Zhang, The First Outpatient Center, School and Hospital of Stomatology, Peking University, 100034 Xishenku Avenue Jia 37, Xicheng District, Beijing, China, Tel: 86-10-53295009, Fax: 86-10-62174226, E-mail:
Clin Med Img Lib, CMIL-2-035, (Volume 2, Issue 3); ISSN: 2474-3682
Published Date: March 24, 2016
Citation: Qiao J, Liu F, Zu-Yan Z (2016) Clinical and Radiographic Characteristics of Hereditary Gingival Fibromatosis. Clin Med Img Lib 2:035.
Copyright: © 2016 Qiao J, et al. This is an open-access content distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Hereditary gingival fibromatosis, also known as congenital familial fibromatosis or idiopathic fibromatosis, is a rare genetic disorder with prevalence of 1/750000 [1,2]. This disorder may show as an isolated disease entity or as part of a syndrome [3,4]. As a single disease entity, it is typically transmitted as an autosomal dominant trait [5]. The main clinical features of hereditary gingival fibromatosis include severe generalized and progressive gingival overgrowth [6,7]. It can involve attachment gingiva, marginal gingiva and interdental gingival papilla, which always cover the teeth partially or completely. Gingiva are smooth, firm and usually normal in color. This disease usually appears during childhood and occasionally delays eruption of teeth [8,9]. The body and mental development of patients are normal [10]. The most important treatment for hereditary gingival fibromatosis is dental plaque control and elimination of gingival inflammation [11,12]. Gingivectomy is usually performed after adolescence [13].

We show a 12-year-old Chinese girl in this report. She has obvious gingival overgrowth since her birth. Her father (42-year-old) and his ancestors all had similar status. The girl's intraoral image is shown in Figure 1. Figure 2 shows her panoramic radiograph. Her father's intraoral image is shown in Figure 3.

Informed Consent

An informed consent was obtained from the girl and her father.

Figure 1: Intraoral image of the patient

Figure 2: Panoramic radiograph of the patient.

Figure 3: Intraoral image of her father.

  1. Pappachan B, Narayan JV, Nayak A (2002) Idiopathic gingival fibromatosis: A neglected case. Indian J Radiol Imaging 12: 335-338.

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  5. Hart TC, Zhang Y, Gorry MC, Hart PS, Cooper M, et al. (2002) A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1. Am J Hum Genet 70: 943-954.

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  8. Kavvadia K, Pepelassi E, Alexandridis C, Arkadopoulou A, Polyzois G, et al. (2005) Gingival fibromatosis and significant tooth eruption delay in an 11-year-old male: a 30-month follow-up. Int J Paediatr Dent 15: 294-302.

  9. Hakkinen L, Csiszar A (2007) Hereditary gingival fibromatosis: characteristics and novel putative pathogenic mechanisms. J Dent Res 86: 25-34.

  10. Gawron K, Lazarz-Bartyzel K, Chomyszyn-Gajewska M (2014) Clinical presentation and management of a rare case of unilateral idiopathic gingival fibromatosis. Dent Med Probl 51: 546-552.

  11. Shetty AK, Shah HJ, Patil MA, Jhota KN (2010) Idiopathic gingival enlargement and its management. J Indian Soc Periodontol 14: 263-265.

  12. Bozzo L, de Almedia OP, Scully C, Aldred MJ (1994) Hereditary gingival fibromatosis. Report of an extensive four-generation pedigree. Oral Surg Oral Med Oral Pathol 78: 452-454.

  13. Tripathi AK, Dete G, Saimbi CS, Kumar V (2015) Management of hereditary gingival fibromatosis: A 2 years follow-up case report. J Indian Soc Periodontol 19: 342-344.

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