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Genetics and Genome ResearchISSN: 2378-3648

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 Open Access DOI:10.23937/2378-3648/1410032

Sequence and Expression Analysis of Procine GLI3 gene

Ying Wang, Zhengwei Zhang, Yifan Dai and Haiyuan Yang

Article Type: Research Article | Indexed Archive: Volume 4

GLI family zinc finger 3 (GLI3) has been shown to play a critical role in the regulation of Hedgehog signaling, with important implications in embryonic and postnatal development. However, the molecular characteristics of GLI3 gene and its expression profile in pig tissues have yet to be elucidated....

 Open Access DOI:10.23937/2378-3648/1410031

Deriving Transition Probabilities and Evolutionary Distances from Substitution Rate Matrix by Probability Reasoning

Xuhua Xia

Article Type: Review Article | Indexed Archive: Volume 4

Substitution rate matrices are used to correct multiple hits at the same sites, which requires the derivation of transition probabilities and evolutionary distances from substitution rate matrices. The derivation is essential in molecular phylogenetics and phylogenomics....

 Open Access DOI:10.23937/2378-3648/1410030

Thermo Stability of DNA Methylation Marks in Human Sperm

Timothy G Jenkins, Monis B Shamsi, Emma James, Kenneth I Aston and Douglas T Carrell

Article Type: Research Article | Indexed Archive: Volume 4

Shipping of various tissues, including sperm, for the purposes of diagnostic testing and/or collaborative scientific pursuits is commonly performed. While many sample attributes are largely stable during the shipping process regardless of shipping environment, some physical factors such as temperature, duration of storage and other handling conditions may affect certain features of these samples including a commonly assessed epigenetic mark, DNA methylation....

 Open Access DOI:10.23937/2378-3648/1410029

Testing the Mutagenicity Potential of Chemicals

Geert R Verheyen, Koen Van Deun and Sabine Van Miert

Article Type: Research Article | Indexed Archive: Volume 4

All information for the proper development, functioning and reproduction of organisms is coded in the sequence of matched base-pairs of DNA. DNA mutations can result in harmful effects and play a role in genetic disorders and cancer. As mutations can arise through exposure to chemical substances, testing needs to be done on substances that humans and animals can be exposed to....

Volume 4
Issue 1