Open Access DOI:10.23937/2643-4571/1710061

Heterotopic Ossification in a 2-year-old girl: Fibrodysplasia Ossificans Progressiva

Mridul Singh, Anushka Aggarwal, Sneha Bhosale, Meera Shah, Renu Kumawat, Anita Mahajan and Sundeep Upadhayaya

Article Type: CASE REPORT | First Published: April 12, 2025

We report a case of a two-year-old girl presenting with progressive multiple bony swellings over the neck and back, diagnosed as Fibrodysplasia ossificans progressiva (FOP) based on radiological and genetic tests. FOP is an extremely rare disorder of heterotopic ossification which leads to progressive immobility. Efforts to correct deformities by surgical resection further stimulate new bone formation and lead to clinical worsening. Classically, FOP presents as malformation of the great toes and...

 Open Access DOI:10.23937/2469-5769/1510137

The Assessment of Five Years Results for Congenital Talipes Equinovarus Treatment at Saint Francis Rural Referral Hospital in Kilombero, Mororgoro Tanzania

Theresia Andrea Karuhanga, Br Joseph Swai, Fassill Tekie, Wilfred Gingo, Prosper Sitta, Rahabu Morro, Ashura Ramadhani, Bartazari Sakuran and Casian Magori

Article Type: CLINICAL PEDIATRIC RESEARCH | First Published: April 14, 2025

Congenital talipes equinovarus (CTEV) may be defined as a fixation of the foot in adduction. It is one of the common developmental malformations of the musculoskeletal system. To date, there is no global appropriate medical care. On addition to poverty, ignorance and inadequate health system are the major risk factors to the CTEV burden to developing countries. The Pirani scoring system is an instrumental tool for assessing both the severity of the deformity, and the progress of treatment....

 Open Access DOI:10.23937/2469-5769/1510136

Experience of Mothers of Children with Down syndrome at the Cocody University Hospital (Côte d’Ivoire)

Kouamé Cyprien Kouakou, Ane Leon Guillaume, Djivohessoun Augustine C, Andre Marius Gro-Bi, Isabelle Djoman, Komenan Amoro Mansou, Dainguy M and Amorissani Folquet

Article Type: ORIGINAL ARTICLE | First Published: April 09, 2025

Down syndrome or trisomy 21 is the most common chromosomal aberration and the leading cause of intellectual disability in the world. It has complex repercussions on the lives of children and their families. This was a prospective descriptive study from April 1, 2019, to January 31, 2021 (22 months) in the medical genetics unit of the Cocody University Hospital on children with trisomy 21 and their mothers. The descriptive qualitative approach was used. Data were collected using clinical intervie...

 Open Access DOI:10.23937/2469-5769/1510135

Therapeutic and Evolutionary Aspects of Antiretroviral Treatment (ART) for Children in Libreville

Lembet Mikolo AM, Eyi Nzong C, Midili TL, Mekame Méyé A, Mabery Ngrodet Adryana, Kiba Live Gael, Mintsa Mi Nkama JE, Koumba Maniaga R, Manga Koumba A, Mayombo Moutsatsa J, Nguemou Mba N, Kuissi Kamkaing E and Ategbo S

Article Type: ORIGINAL RESEARCH ARTICLE | First Published: April 09, 2025

HIV remains a major public health problem worldwide. Without treatment, the disease progresses rapidly in children, half of whom die before the age of 2. The aim was to study the therapeutic and evolutionary aspects of HIV infection in children followed up in the various care centres....

 Open Access DOI:10.23937/2469-5807/1510162

Spindle Cell Papillary Thyroid Carcinoma (SC-PTC): A Rare and Challenging Case in Thyroid Pathology

Mellouki Abderrahmane, Evrard Niyonkuru, Reda Chelly, Meriem Regragui, Mehdi Karkouri and Mohamed Mahtar

Article Type: CASE REPORT | First Published: April 12, 2025

Spindle cell PTC (SC-PTC) is an exceedingly rare PTC subtype believed to have a favorable prognosis. However, a clear and precise definition of SC-PTC is still lacking. Currently, spindle cells in SC-PTC are regarded as a form of metaplasia, wherein follicular carcinomatous cells transform into mesenchymal-like cells devoid of papillary nuclear features. We report the case of a 45-year-old woman diagnosed with spindle cell PTC. The patient presented cervical swelling that progressed gradually ov...

 Open Access DOI:10.23937/2469-5742/1510095

Observational Analysis of A Retrospective Cohort on Indications and Complications of Double-J Ureteral Stents

Saleh Nedjim A*, Hissein Hagguir, Adil Kbirou, Amine Moataz, Mohamed Dakir, Adil Debbagh and Rachid Aboutaieb

Article Type: ORIGINAL RESEARCH ARTICLE | First Published: April 09, 2025

This was a cross-sectional prospective study conducted over twelve months in the urology department of the Ibn Rochd University Hospital in Casablanca, Morocco. Included in the study were patients who were hospitalized for complications related to double J ureteral stents. The parameters studied were age, sex, indication for JJ placement, duration of stent placement, diagnosis, renal function, urine microscopic analysis, imaging (plain abdominal radiograph or uro-CT), and therapeutic approach. D...

 Open Access DOI:10.23937/2469-5823/1510206

Are Pharmacological Managements Effective than Non- Pharmacological Managements for Treating Pain in Neonates Admitted to NICU? A Systematic Review

Girum Sebsibie Teshome and Teklemariam Gultie Ketema

Article Type: ORIGINAL RESEARCH ARTICLE | First Published: April 10, 2025

Neonates admitted to the Neonatal Intensive Care Unit (NICU) often undergo numerous painful procedures and interventions that, if inadequately managed, can lead to adverse neurodevelopmental outcomes and increased stress responses. Managing pain in neonates is thus essential, but the most effective approach remains unclear. While both pharmacological and non-pharmacological strategies are widely used, a systematic comparison is needed to determine which is more beneficial....

 Open Access DOI:10.23937/2474-3682/1510248

Morphea in Plate

Youssef Zemmez, Abdourahman Moussa, Rachid Frikh and Naoufal Hjira

Article Type: Image | First Published: March 30, 2025

A 45-year-old woman with no previous pathological history of any kind consulted us for skin lesions on the trunk, which had started on the back and extended to the left breast. Dermatological examination revealed three skin lesions on the back, in the form of plaques, the largest of which was located on the left lumbar region and measured 6 centimetres in diameter. The other two were located on the middle dorsal region and measured 2 centimetres in diameter, as well as on the left breast....

 Open Access DOI:10.23937/2378-346X/1410159

Recurrence of Benign Orbital Solitary Fibrous Tumor

Muhammad Awan, BS, Lea Carter, DO, Heidi Mina, MD and Jorge Agi, MD

Article Type: Case Report | First Published: March 27, 2025

Orbital solitary fibrous tumors are rare, accounting for less than 1% of all orbital tumors. These tumors are typically benign and surgical excision is curative, although recurrence of the neoplasm may occur after surgery. We report a case of a recurrent orbital solitary fibrous tumor in a 30-year-old female patient. The patient initially underwent an orbitotomy with partial resection for a right periorbital lesion in April 2024 but presented it to the clinic in September 2024 with worsening rig...

 Open Access DOI:10.23937/2469-567X/1510097

Broad-Spectrum Anti-HIV Microbicide Activity of the Non- Nucleoside Reverse Transcriptase Inhibitor UC781

Mohammad M Hossain, PhD and Micheal A Parniak

Article Type: Research Article | First Published: March 26, 2025

The tight-binding nonnucleoside reverse transcriptase inhibitor (NNRTI) UC781is under development as a topical microbicide to prevent sexual transmission of the human immunodeficiency virus type 1 (HIV-1). However, there are concerns whether UC781 will be broadly effective against different HIV subtypes as well as against the increasingly prevalent NNRTI-resistant HIV strains....