Open Access DOI:10.23937/2572-3278.1510001
Nutritional Medicine and Diet Care
Ross Stewart Grant
Article Type: Editorial | First Published: February 16, 2015
A number of previously well-established fundamentals to nutritional health have been challenged in recent times. The merits of the well balanced low fat diet, built on whole grains, vegetables, fruits, nuts, seeds and grains with restricted use of meats and dairy is now being vigorously debated by those advocating various alternatives including; the no grain Paleolithic diet or the high meat protein Atkins diet, or the high fat (low omega-3) Weston Price diet....
Open Access DOI:10.23937/2378-2951/1410021
High Prevalence of Atrial Fibrillation in Elderly Patients Hospitalized with Heart Failure
Urrutia A, Cepeda JM, Formiga F, Manzano L, Conde-Martel A, Aramburu-Bodas O, Suarez I, Gonzalez-Franco A, Quiros-Lopez R and Montero Perez-Barquero M
Article Type: Research Article | First Published: February 12, 2015
Background: Atrial Fibrillation (AF) is a common condition in the elderly and often occurs together with Heart Failure (HF). The differences between elderly patients with HF according to the presence or absence of AF were analysed. Material and methods: Patient data were collected from consecutively admitted patients 75 years of age and older with acute decompensated HF from the Spanish National Heart Failure Registry (RICA) with data retrieved from internal medicine settings....
Open Access DOI:10.23937/2378-346X/1410012
Effect of Interferon Alfa-2a on Peripheral Blood CD4+CD25+ T Regulatory Cells in Patients with Behcet Uveitis: Preliminary Study
Aylin Koc, Sumru Onal, Aysin Tulunay, Haluk Kazokoglu, Emel Eksioglu Demiralp, Haner Direskeneli and Sule Yavuz
Article Type: Research Article | First Published: February 13, 2015
Purpose: To evaluate the phonotypical and functional effect of interferon alfa-2a therapy on peripheral blood CD4+CD25+ T regulatory (Treg) cells in patients with Behcet uveitis. Methods: Blood was taken from 5 patients with refractory Behcetpanuveitis and 5 age-matched healthy controls. Flow cytometric analysis of CD4+CD25+Treg cells was performed. CD4+CD25+Treg cells were separated by magnetic-assisted cell sorting and co-cultured. Cytokine levels in the supernatants were determined by ELISA.....
Open Access DOI:10.23937/2378-346X/1410011
Generation of Retinal Progenitor Cell Sheets which Differentiate into Rhodopsin Positive Photoreceptors from Mouse iPS Cell Derived Retinal Progenitor Cell Clones
Noboru Suzuki, Jun Shimizu, Chieko Hirotsu, Erika Takada, Nagisa Arimitsu, Yuji Ueda, Naruyoshi Fujiwara, Tomoko Suzuki and Kenji Takai
Article Type: Research Article | First Published: February 05, 2015
We previously reported successful establishment of retinal progenitor cell clones. Here, we cultured them on temperature reversible gelation polymer, with supplementation of several chemokines. The retinal progenitor cell clones formed a cell sheet with extension of their axon like processes. RT-PCR of the cell sheets after two week culture, they were positive for retinal ganglion cell markers, bipolar cell markers, and photoreceptor cell markers. Immunohistochemistry suggested that the cell she...
Open Access DOI:10.23937/2378-3419/2/1/1013
Gene-Specific Promoter Methylation Status in Hormone-Receptor-Positive Breast Cancer Associates with Postmenopausal Body Size and Recreational Physical Activity
Lauren E. McCullough, Jia Chen, Alexandra J. White, Xinran Xu, Yoon Hee Cho, Patrick T. Bradshaw, Sybil M. Eng, Susan L. Teitelbaum, Mary Beth Terry, Gail Garbowski, Alfred I. Neugut, Hanina Hibshoosh, Regina M. Santella, Marilie D. Gammon
Article Type: Original Article | First Published: February 09, 2015
Introduction: Breast cancer, the leading cancer diagnosis among American women, is positively associated with postmenopausal obesity and little or no recreational physical activity (RPA). However, the underlying mechanisms of these associations remain unresolved. Aberrant changes in DNA methylation may represent an early event in carcinogenesis, but few studies have investigated associations between obesity/RPA and gene methylation, particularly in postmenopausal breast tumors where these lifest...
Open Access DOI:10.23937/2469-5726/1510001
Subchondral Bone: An Emerging Target for Treatment of Osteoarthritis
Lukas A. Holzer
Article Type: Editorial | First Published: February 15, 2015
Osteoarthritis (OA) is a long-term chronic disease that is characterized by the deterioration of cartilage in joints resulting in stiffness, pain and impaired range of motion. OA is a disease that is associated with ageing. However, there are various factors e.g. obesity, lack of exercise, genetical abberations, occupation, trauma and gender that contribute to progression of OA. Osteoarthritis is the most common form of arthritis. The World Health Organization estimates that globally 25% of adul...
Open Access DOI:10.23937/2572-4037.1510002
Narcissism: It's more Complex than High Self-Esteem
Marion Wallace
Article Type: Editorial | First Published: January 30, 2015
Narcissism is often used synonymously with high or inflated selfe-steem. Indeed, narcissism is illustrated by individuals with grandiose self-views and a need for admiration. The origins of the term stem from Greek mythology where a young man named Narcissus became enamored with his reflection. However, individuals with higher levels of narcissistic traits make up a unique combination of high and vulnerable self-esteem. Since narcissism is more complex than high self-esteem, individuals with hig...
Open Access DOI:10.23937/2572-4010.1510001
Anti-Obesity Drugs: A Necessary Part of Treatment
Raquel Cristina Lopes Assis Coelho
Article Type: Editorial | First Published: January 29, 2015
Worldwide obesity prevalence has nearly doubled since 1980. Obesity is reaching epidemic proportions worldwide and it is correlated with various comorbidities, among which the most relevant are diabetes mellitus, arterial hypertension, and cardiovascular diseases. Obesity management is a modern challenge because of the rapid evolution of unfavorable lifestyles. Due to numerous co-morbidities, obesity represents a serious health and socioeconomic problem worldwide....