Open Access DOI:10.23937/2572-4037.1510004
Multi-family Groups for First Episode Psychosis in an Adult Psychiatric Care Department: A Study Design
Rosini E, Calabro G, Mancinelli I, Pacifici MP, Pucci D, Caltagirone SS, De Pisa E, Narracci A, Girardi P and Comparelli A
Article Type: Short Report | First Published: February 21, 2015
Introduction: In 1958, Jorge Garcia Badaracco initiated weekly meetings between psychotic patients and their parents in Buenos Aires. On the basis of these experiences, he founded a new psychotherapeutic method, with an open setting based on multifamily groups (MFG), for patients affected by severe psychiatric illness. In Italy, there are several public psychiatric services in which MFG is followed, but there are few studies testing its validity. Herein, we describe a design study addressing the...
Open Access DOI:10.23937/2377-3634/1410021
Early Release of HMGB1 may Aggravate Neuronal Damage after Transient Focal Ischemia in Diabetic Rat Brain
Naohiro Iwata, Mari Okazaki, Shinya Kamiuchi, Meiyan Xuan, Hirokazu Matsuzaki, Takeshi Sakamoto and Yasuhide Hibino
Article Type: Research Article | First Published: February 22, 2015
Objective: High Mobility Group Box 1 (HMGB1) released extracellularly from necrotic cells evokes delayed inflammatory processes via interaction with the Receptor for Advanced Glycation End Products (RAGE) or Toll-like Receptors (TLR) in postischemic brain. The diabetic state (DM) aggravated cerebral ischemic injury following the stroke in rats. Therefore, we examined the behavior of HMGB1 and the expression of RAGE in non-DM and DM rat brain after middle cerebral artery occlusion followed by rep...
Open Access DOI:10.23937/2572-4037.1510003
Effects of Readiness to Change, Quit History, and Health Perceptions on Depressive Symptoms among Young Adult Smokers
Dawn W. Foster, Georges E. Khalil, Samantha G. Farris, Till W. Barnighausen and Alexander V. Prokhorov
Article Type: Research Article | First Published: February 21, 2015
Background: The current study sought to evaluate the main and interactive effect of health perceptions, smoking quit attempt history, and readiness to change with respect to depressive symptoms among college student smokers. Method: The present data came from baseline data from a randomized trial and included 495 undergraduate students who reported smoking at least 1 cigarette per day. Results: A three-way interaction emerged between smoking quit attempt history, health perceptions, and readines...
Open Access DOI:10.23937/2469-567X/1510005
T-reg are the Predominant CD4+ T-Cell Subset Productively Infected with HIV-1 at Sites of Dual HIV/TB Infection
Christina S Hirsch, Shigou Liu, Joy Baseke, John Lusiba Kafuluma, Mary Nserko, Harriet Mayanja-Kizza and Zahra Toossi
Article Type: Research Article | First Published: February 10, 2015
Background: Regulatory T-cells (T-reg) are expanded during active tuberculosis (TB) regardless of HIV-1-infection, particularly at sites of M. tuberculosis infection. In HIV-1 disease, T-reg are targeted by HIV-1 infection. However, whether they contribute to promotion of HIV-1 infection at sites of HIV/TB is unknown. Methods: Pleural fluid mononuclear cells (PFMC) from HIV/TB patients with pleural TB were characterized by immunostaining and FACS analysis for surface markers CD4, CD127, CCR5, CX...
Open Access DOI:10.23937/2474-3631/1510001
Embracing Reward Deficiency Syndrome (RDS) Solution System: A Genomic Thrust
Kenneth Blum, Marcelo Febo, Zsolt Demotrovics and Rajendra D. Badgaiyan
Article Type: Editorial | First Published: February 21, 2015
The mysteries and underlying causes of addictive disorders have spawned a number of important questions which still plague researchers and treatment professionals alike. What populations are susceptible to addictive disorders based upon genetic predisposition? Why are they more susceptible than others? What considerations or adjustments must be made to care plans of certain individuals to maximize their opportunity for recovery?...
Open Access DOI:10.23937/2572-4045.1510001
Auto Transplantation of Adipose and Adipose Derived Stem Cells
Jay M. Pensler
Article Type: Editorial | First Published: February 16, 2015
Auto transplantation of adipose cells and adipose derived stem cells is an increasingly popular procedure in Aesthetic Plastic Surgery. Utilizing liposuction to harvest an individual's fat the lipo-aspirate that was once harvested, is purified prior to auto transplantation. A number of techniques including low speed centrifugation, decanting, and/or blotting the various layers of the aspirated are utilized to increase the harvest of multi-potential stem cells and adipose cells while removing col...
Open Access DOI:10.23937/2572-3278.1510002
Inaugural Editorial - Journal of Nutritional Medicine and Diet Care
Basil Aboul-Enein
Article Type: Editorial | First Published: February 17, 2015
It is with profound pleasure that I welcome readers, reviewers, editors, and authors to this inaugural issue of the Journal of Nutritional Medicine and Diet Care (JNMDC). The Journal of Nutritional Medicine and Diet Care is an open access, peer reviewed, scientific journal that provides rapid dissemination of research in all areas of human and animal nutrition, dietetic practice and public health nutrition, dietary interventions, nutrigenomics, molecular nutrition, and other related topics of in...
Open Access DOI:10.23937/2469-5807/1510001
Why the Hypocholesteremia must not be Neglected?
Elisabetta Albi
Article Type: Editorial | First Published: February 17, 2015
During the last ten years studies on the role of cholesterol in the development and progression of cancer process and observations of severe hypocholesterolemia in patients with solid tumours and hematologic malignancies have been extended. Th cancer cell incorporates cholesterol with avidity and reduces its serum level. In normal cells, cholesterol binds sphingomyelin with very long-chained saturated fatty acids to form membrane lipid raft that acts as platform for proteins and receptors....
Open Access DOI:10.23937/2469-5726/1510002
Difficulties in Defining a Clinical Score for Acute Flare-Ups in an Osteoarthritic Knee
Hassan M Bassiouni and Ahmed A Negm
Article Type: Editorial | First Published: February 19, 2015
The basic idea of this editorial was to try to propose new techniques and laboratory measurements for future incorporation into a new score for identifying an acutely inflamed osteoarthritic knee joint. In the area of research, defining clinical status was always a hurdle to proper patient recruitment because working on quiet cases of OA with minimal to moderate pain is totally different from working on acute cases of OA with a lot of pain. Hence the problem of defining the clinical status at ti...
Open Access DOI:10.23937/2469-5742/1510001
Fournier's Gangrene and Prognostic Scoring Systems
Bulent Erol
Article Type: Editorial | First Published: February 17, 2015
A Fournier's gangrene (FG), a life-threatening necrotizing fasciitis of the male and female genitourinary tract was first described in the 1883. FG is an uncommon necrotizing fasciitis of genitalia and perineum that has high mortality and morbidity. Many predisposing factors have been reported, including perianal disease, urethral stricture, local trauma, diabetes mellitus, and malignancy. Systemic diseases such as cardiac failure, hypertension, and renal insufficiency may have an adverse effect...