Open Access DOI:10.23937/2474-3690/1510001
Review of 2003 to 2015 Guidelines on Treatment of Hypertension in Patients with Coronary Artery Disease
Wilbert S. Aronow
Article Type: Review Article | First Published: July 18, 2015
Patients with coronary artery disease should have their modifiable coronary risk factors intensively treated. Dietary sodium should be reduced. Hypertension should be treated with beta blockers and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. Long-acting nitrates are effective antianginal and antiischemic drugs. Calcium channel blockers may be added if angina persists despite beta blockers and long-acting nitrates....
Open Access DOI:10.23937/2378-3419/2/3/1018
A Simple Two-Stage PCR Method for Quality Amplification of Degenerate DNA
Ebili Henry O, Ham-Karim Hersh Abdul and Ilyas Mohammad
Article Type: Original Article | First Published: July 06, 2015
Formalin-fixed, paraffin-embedded (FFPE) tissue banks are invaluable to cancer genetics and biomarker discovery. However, FFPE tissue-derived DNA is degenerate. As such, any PCR technique which will give adequate amplification of such DNA to enable downstream applications is important to the characterization of genetic biomarkers and to personalized medicine. The aim of this article is to describe a two-stage PCR method which efficiently amplifies degenerate FFPE tissue-derived DNA. Amplicon enr...
Open Access DOI:10.23937/2377-3634/1410034
Prevalence and Risk Factors of Poorly Controlled Diabetes Mellitus in a Clinical Setting in Guayaquil, Ecuador: A Cross-Sectional Study
Arosemena Coronel M, Sanchez Armijos J, Tettamanti Miranda D, Vasquez Cedeno D, Chang A and Navarro Chavez M
Article Type: Research Article | First Published: July 16, 2015
Objective: This study aimed to explore the prevalence of and factors associated with poorly controlled diabetes mellitus (PCDM) in a clinic setting in Ecuador. Methods: A single-center, cross-sectional study conducted in the outpatient endocrinology clinic in Guayaquil, Ecuador registered 209 participants with type 2 diabetes mellitus, tested for glycosylated hemoglobin and interviewed face-to-face using questions from the Instrument to Measure Lifestyle in Diabetics (IMEVID) Questionnaire. Logi...
Open Access DOI:10.23937/2572-4193.1510001
The Subtleties and Nuances of Pediatric Sedation: A Disappearing Art for Managing the Apprehensive Child Patient
John E. Nathan
Article Type: Editorial | First Published: July 04, 2015
Pre-cooperative and severely apprehensive children have immature cognitive abilities, a restricted range of coping skills, brief or negligible attention spans, and virtually no experience coping with stress. For these children conventional communication strategies may often prove inadequate or inappropriate to overcome the behavioral manifestations of childhood dental fear and anxiety. Well- chosen pharmacological approaches has potential to permit in-office treatment, avoid aversive measures, a...
Open Access DOI:10.23937/2572-3235.1510001
Unilateral Renal Cystic Disease: A Case Report of A Rare Disease and Review of Literature
Rushani T Samarakoon and Thamara Rajapakse
Article Type: Case Report | First Published: July 28, 2015
Unilateral renal cystic disease (URCD) is a rare entity with few reported cases. This condition is often misdiagnosed for other cystic renal diseases like autosomal dominant polycystic kidney disease, cystic dysplastic kidney disease and cystic nephroma. Nevertheless, this is a benign entity with a potential for good prognosis. Imaging features, supported by background clinical and biochemical findings, diagnosis of URCD is possible. A case of URCD is reported here, having diagnosed on imaging f...
Open Access DOI:10.23937/2572-4045.1510006
Incidental Discovery of a Donor-Derived Urothelial Carcinoma Following Kidney Transplantation
Kathryn Milks, Sriyesh Krishnan, Melanie Caserta, Robert J Stratta and Hisham Tchelepi
Article Type: Case Report | First Published: June 20, 2015
Urothelial carcinoma in renal transplant patients has been well described, particularly in the Asian literature, owing to the higher incidence of the disease in this part of the world, both in the native urothelial system and in the transplanted kidney. In the United States, however, urothelial carcinoma after kidney transplant is quite rare in the native urothelial system and extraordinarily rare in the renal allograft. It has been proposed in areas with a high incidence of urothelial carcinoma...
Open Access DOI:10.23937/2377-3634/1410033
The Relation between Overweight, Obesity and Plasma Lipids in Saudi Adults with Type 2 Diabetes
Khalid S. Aljabri, Samia A. Bokhari and Ahmad Akl
Article Type: Research Article | First Published: June 30, 2015
Diabetes mellitus is the third greatest cause of death all over the world and is responsible for many complications affecting various organs in the body. Th prevalence of diabetes for all age-groups worldwide was estimated to be 2.8% in 2000 and 4.4% in 2030. Th prevalence of diabetes mellitus among adults in Saudi Arabia is 30%. Worldwide and nationally epidemic exists with respect to diabetes mellitus, primarily because of increased rates of obesity. Obesity has become widespread in developed ...
Open Access DOI:10.23937/2377-3634/1410032
The Crossroad of Inflammation and Diabetes: Role of Toll-Like Receptor
Behrouz Salehian and Vahid Mahabadi
Article Type: Review Article | First Published: June 29, 2015
A different facet of type 2 diabetes was recognized in the early 80s with the demonstration of the 'state of coagulation activation' and 'endothelial dysfunction / activation' in not only type 2 diabetes but also in obesity. The discovery of tumor necrosis factor (TNF) alpha and its physiological role including many aspects of coagulation activation and endothelial dysfunction was later found to have a correlation with adiposity and type 2 diabetes. Further knowledge in the metabolic function of...
Open Access DOI:10.23937/2377-9004/1410053
Cervical Varices Presenting as Vaginal Bleeding: A Description of Two Cases and A Management Plan
Kathy Chyjek, Catherine Hutz, Charles Macri, Jeffrey Berger, Anthony Venbrux, Nadia Khati, Dorothy Bulas and John Larsen
Article Type: Case Report | First Published: August 01, 2015
We present two cases of cervical varices found in the setting of second and third trimester bleeding, report on the clinical outcomes and propose a management plan. Both of our patients were delivered between 38-39 weeks gestation and required interdisciplinary meetings between Obstetrics and Gynecology, Anesthesiology, Neonatology and Interventional Radiology to prepare for delivery....
Open Access DOI:10.23937/2377-9004/1410052
Pregnancy Outcome in Women with History of Uterine Rupture or Dehiscence
Sagy Shick and Ran Neiger
Article Type: Case Series | First Published: July 30, 2015
The rate of Cesarean deliveries continues to increase world-wide. Cesarean delivery, in particular when repeated, is associated with an increased risk of several complications in subsequent pregnancies, including uterine rupture and uterine dehiscence. Rupture of a uterine scar is defined as a disruption of the full thickness of the uterine wall including the overlying visceral peritoneum (uterine serosa). It occurs most frequently in women who have undergone previous uterine surgery (e.g. Cesar...