Open Access DOI:10.23937/2378-2951/1410047
Guidewire Fracture during Crossing A Chronic Coronary Total Occlusion: A Troublesome Experience
ErsanTatli, MustafaYilmaztepe, Ali Buturak and Yusuf Can
Article Type: Case Report | First Published: August 30, 2015
Increased interest focusing on coronary chronic total occlusions has emerged since several studies have proven improved cardiovascular outcomes and quality of life after successful chronic total occlusion (CTO) revascularization. CTO of an epicardial coronary artery is one of the leading challenging complex lesion type when percutaneous coronary intervention (PCI) is indicated. Advanced antegrade and retrograde techniques performed with dedicated equipment have provided significant improvements ...
Open Access DOI:10.23937/2469-5807/1510010
Overview of Coroner's Adult Autopsies in England
Husayn Al Mahdy
Article Type: Review Article | First Published: September 11, 2015
This article provides an overview of coroner's autopsies in England with the aim of improving the service and hence provide accurate death certification as well as a learning experience for clinicians caring for patients. The system that has evolved has neither improved the service nor has it led to a learning experience for the clinicians. Compatibility of clinical features ante-mortem combined with post-mortem findings are lacking and involvement of the clinicians is almost non-existent. The c...
Open Access DOI:10.23937/2469-5807/1510009
Factors Predicting Response to Neoadjuvant Therapy of Hepatic Metastasis from Colorectal Carcinoma
D. Cortes Guira,, MJ Fernandez-Acenero, Damian Garcia-Olmo and C. Pastor Idoate
Article Type: Review Article | First Published: September 03, 2015
Neoadjuvant chemotherapy (NAC) is a widely used therapeutic option for patients with resectable hepatic metastasis from colorectal carcinoma. In this setting, the intent of NAC is to reduce metastatic size and make surgery easier and/or less extensive, mostly in patients that are amenable to surgery. Several studies confirm that response to neoadjuvant therapy is indicative of a better prognosis for such patients and several methods have been proposed and validated to measure both radiological a...
Open Access DOI:10.23937/2469-5807/1510008
Ovarian Neoplasm in a Patient with Prior Breast Carcinoma - Challenges and Pitfalls in Diagnostic Process
Elena Arabadzhieva, Sasho Bonev, Lyubomira Dimitrova, Atanas Yonkov, Dimitar Bulanov, Vesela Ivanova and Violeta Dimitrova
Article Type: Case Report | First Published: September 02, 2015
We present a case of 58-year-old woman who underwent bilateral adnexectomy with small bowel resection during urgent operation for an incarcerated umbilical hernia. There was a slight enlargement in both ovaries and presence of cystic formation with some papillary structures in the right one. Histologically, bilateral infiltration of tumor cells with moderate cytological and nuclear atypia and tubular, nested and cystic growth pattern was observed. The patient had a long list of co-morbidities: l...
Open Access DOI:10.23937/2469-5807/1510007
The Optimization of Igm In-House ELISA for the Laboratory Diagnosis of Melioidosis in Malaysia
Azura Mohd Noor, Norazah Ahmad and Wan Rozita Wan Mahiyuddin
Article Type: Research Article | First Published: September 02, 2015
Melioidosis is a life-threatening infectious disease which can lead to high mortality and death within 48 hours if treatment is delayed. Detection of antibodies against Burkholderia pseudomallei may help in early diagnosis of melioidosis. This study was carried out to optimize an in-house ELISA for the detection of Immunoglobulin M (IgM) against B. pseudomallei in suspected acute melioidosis patients in Malaysia. Three different concentrations of crude B. pseudomallei cells antigen (0.200 mg/ml,...
Open Access DOI:10.23937/2572-4053.1510003
Sleep Characteristics in Blind Subjects
Fructuoso Ayala-Guerrero and Graciela Mexicano
Article Type: Research Article | First Published: September 14, 2015
The sleep patterns of ten blind adults and their matched controls were studied during three consecutive nights. The first night was allowed for adaptation. Significant electroencephalographic and quantitative findings were obtained from nights 2 and 3. Although alpha-like rhythm was registered in only one blind subject during wakefulness, it was displayed by 8 of the 10 blind participants of this study during REM sleep. This rhythm was also present during the N2 sleep stage. The delta phase of s...
Open Access DOI:10.23937/2572-4053.1510002
Marked Increases in Alpha Power Over the Left Prefrontal Region During Days Following Shift Work: A Case Report
Nirosha J. Murugan, Nicolas Rouleau, Lukasz M. Karbowski, Andrew P. Lapointe and Michael A. Persinger
Article Type: Case Report | First Published: September 10, 2015
Quantitative electroencephalographic (QEEG) measurements were completed for a 35 year old of paramedic following two to five days of shift change and rest periods. The most conspicuous and reliable change was a marked increase (factor of 5) in power within the alpha band over the left prefrontal region and, to a lesser degree, increased power within the low-beta band over the right parietal region during the test periods after no work days. These results indicate that regions of cerebral cortice...
Open Access DOI:10.23937/2469-5858/1510005
Association of SORL1 Polymorphisms with the Risk of Amnestic Mild Cognitive Impairment in the Han Chinese Population
Lili Zhang, Xiaowei Liu, Bailing Wang, Qing Xu, Jianzhong Zhu, Feng Zhang and Chunhui Jin
Article Type: Communication | First Published: September 14, 2015
Mild cognitive impairment (MCI) is defined as the symptomatic predementia stage, characterized by cognitive impairment that is not severe enough to influence the usual activities of daily living. MCI is suggested to be a transitional state between healthy aging and clinically probable Alzheimer's disease (AD). Previous studies have identified that single nucleotide polymorphisms (SNPs) in the sortilin-related receptor, L (DLR class) A repeats containing (SORL1) gene are associated with amnestic ...
Open Access DOI:10.23937/2469-5831/1510004
Bayesian Survival Analysis of Genetic Variants in PTPRN2 Gene for Age at Onset of Cancer
Ke-Sheng Wang, Yue Pan, Weize Wang and Chun Xu
Article Type: Research Article | First Published: September 9, 2015
The protein tyrosine phosphatase, receptor type, N polypeptide 2 (PTPRN2) gene may play a role in cancer; however, no study has focused on the associations of genetic variants within the PTPRN2 gene with age at onset (AAO) of cancer. Methods: This study examined 220 single nucleotide polymorphisms (SNPs) within the PTPRN2 gene in the Marshfield sample with 716 cancer cases (any diagnosed cancer, excluding minor skin cancer) and 2,848 non-cancer controls. Multiple logistic regression model and li...
Open Access DOI:10.23937/2469-5831/1510003
A Review of Graphical Approaches to Common Statistical Analyses. The Omnipresence of Latent Variables in Statistics
Emil N. Coman, L. Suzanne Suggs, Maria Coman and Eugen Iordache and Judith Fifield
Article Type: Review Article | First Published: September 4, 2015
We provide a comprehensive review of simple and advanced statistical analyses using an intuitive visual approach explicitly modeling Latent Variables (LV), likely to better illuminate what is assumed in each analytical method and what is actually estimated, by translating the causal relationships embedded in the graphical models in equation form. We recommend the graphical display rooted in the century old path analysis, that details all parameters of each statistical model, and suggest labeling...