Open Access DOI:10.23937/2469-5807/1510013
Liquid Biopsy: A Future Tool for Post Treatment Surveillance in Head and Neck Cancer?
Joost H Van Ginkel, Manon MH Huibers, Rob Noorlag, Remco de Bree, Robert JJ van Es and Stefan M Willems
Article Type: Research Article | First Published: November 30, 2015
The prognosis of head and neck squamous cell carcinoma (HNSCC) is largely based on disease stage. Despite improvements in treatment, recurrence rates are still considered high. Currently, disease progression or regression after curative treatment is monitored by clinical evaluation combined with flexible endoscopy and/or imaging....
Open Access DOI:10.23937/2469-5807/1510011
An Uncommon Cause of Skin Discoloration: Purpura Pigmentosa Progressiva
Charles Joseph Haddad, Judella Haddad Lacle and Charles Michael Haddad
Article Type: Case report | First Published: October 04, 2015
Purpura Pigmentosa Progressiva is also known as Progressive Pigmentary Dermatitis or Schamberg's Disease. It is a disorder causing skin discoloration on the trunk and extremities, and is a lymphocytic capillaritis of unknown etiology. The disease can occur at any age. It is important to be aware of this disorder since it can mimic other diseases and problems including child and elder abuse, thrombocytopenia purpura....
Open Access DOI:10.23937/2572-3308.1510008
Environmental Factors Urging the Development of Atopic Diseases in 75 Children
Arnaldo Cantani
Article Type: Review Article | First Published: September 11, 2015
Atopy can interfere with a child's life at any age level, with varying severity. Intractable diarrhea due to CM allergy (CMA) and AD are the most frequent in infants, where the clinical manifestations are more severe than in older children. Respiratory allergy and bronchial asthma can be serious illnesses in younger as well as in older children....
Open Access DOI:10.23937/2572-3308.1510006
Epinephrine Auto-Injectors
Ozlem Yilmaz Ozbek
Article Type: Short Review | First Published: September 04, 2015
Anaphylaxis is a systemic, life-threatening reaction and immediate treatment is essential. The reaction can be fatal even with epinephrine injection. Epinephrine auto-injectors have been used in the emergency treatment of anaphylaxis since the 1980s. In this review, indications for the prescription, types, administration, and the problems with the use of epinephrine auto-injectors are discussed. The importance of patient and caregiver education is highlighted....
Open Access DOI:10.23937/2572-3308.1510005
Identify the Inhibitors ... and Activate Them
Michael Huber
Article Type: Editorial | First Published: July 22, 2015
In contrast to positively acting signaling elements/ pathways that are typically targeted by small-molecule inhibitors, attenuating/ inhibiting signaling proteins would have to be pharmacologically activated to accomplish suppression of cellular pro-inflammatory reactions. Indeed, the meroterpenoid pelorol identified in sponge extract was demonstrated to efficiently activate SHIP1 phosphatase function and structural analogs thereof exhibited even greater activity in cell and mouse models of infl...
Open Access DOI:10.23937/2572-3308.1510004
Soy Sauce and Allergic Skin Reaction
Keiji Sugiura
Article Type: Editorial | First Published: May 16, 2015
In this editorial, I describe the difficulties of diagnosing soy sauce allergies, since soy sauce produces histamine during brewing and storing. Some Japanese people develop irritation, itching and cellulitis after consuming foods with soy sauce. These symptoms could be caused by soy sauce allergy, histamine poisoning and/or other factors....
Open Access DOI:10.23937/2572-3308.1510003
T helper Regulation and Anti-Cytokine Therapy in Asthma
Zihan Zheng and Xinyi Huang
Article Type: Review Article | First Published: April 15, 2015
Asthma is a complex chronic inflammatory disease of the airways that is of increasing prevalence. Many different cell types are critically involved in its pathogenesis, including several classes of T helper cells. These cells may serve to generally organize the asthmatic response by virtue of the cytokines and other factors they release, which trigger downstream effects on a wide variety of cells....
Open Access DOI:10.23937/2572-3308.1510002
Allergic Rhinitis Medications
Hideaki Shirasaki
Article Type: Editorial | First Published: February 23, 2015
The nasal allergic response is a complex process involving the interaction of many mediators. The current therapeutic strategy is mainly based on drugs (antihistamines, nasal corticosteroids, etc.) and allergen immunotherapy. The most effective medication in persistent rhinitis is topical corticosteroid, which decreases all symptoms. Antihistamines reduce nasal itch, sneeze and rhinorrhea....