Open Access DOI:10.23937/2378-3001/3/1/1036
Inhalable Curcumin is an Efficacious Treatment Strategy for Herpes Simplex Virus Type 1-Induced Neuropathology
Isamu Mori
Article Type: Hypothesis | First Published: January 07, 2016
Turmeric, which is derived from the root of the Curcuma longa plant, is one of the most widely used spices worldwide. Scientists from various disciplines have long studied the medicinal benefits of a polyphenol extract from Curcuma longa, curcumin. It has been shown to have a broad spectrum of pharmacological activities in cancer, inflammation, and Alzheimer's disease (AD). In an epidemiological study, continuous curcumin intake improved cognitive function in aged individuals....
Open Access DOI:10.23937/2378-3001/2/2/1035
Severe Bradycardia after Topical Use of Papaverine during a Pons Cavernoma Surgery
Demian Manzano Lopez Gonzalez, Gerardo Conesa Bertran and Jesus Lafuente Baraza
Article Type: Case Report | First Published: November 05, 2015
Papaverine is a potent smooth muscle relaxant and has vasodilator properties. Topical use of papaverine is widely accepted in neurosurgery to prevent cerebral vasospasm. Growing evidence supports that papaverine may have a neural toxicity effect. We present a case of a 15 years-old patient that was operated on hemorrhagic cavernoma in the floor of the fourth ventricle. A transvermian approach was performed and neurophysiological monitoring was set up. During surgery, the motor evoked potentials ...
Open Access DOI:10.23937/2378-3001/2/2/1034
Association between the ERCC1 Polymorphisms and Glioma Risk: A Meta-Analysis of Case-Control Studies
Liu Yan, Cai Xiao Qin, Zhao Lian Ying, Shen Heng Shan, Hu Jian Wei
Article Type: Original Research Article | First Published: October 13, 2015
Polymorphisms in DNA repair genes have been shown to influence DNA repair processes and to modify cancer susceptibility. Published data regarding the association between excision repair cross-complementing rodent repair deficiency complementation group1 (ERCC1) polymorphisms and glioma risk have been inconsistent and inconclusive. To acquire a more precise effect of the association between these polymorphisms and glioma risk, a meta-analysis was performed....
Open Access DOI:10.23937/2469-5769/1510012
Subacute Metacarpal Osteomyelitis in a Child
Hamdi Kaziz, Thabet Mouelhi, Walid Osman, Mohamed Amine Triki, Nader Naouar and Mohamed Laziz Ben Ayeche
Article Type: Case Report | First Published: December 26, 2015
Subacute osteomyelitis is a rare affection. Clinical presentation is often unclear and can lead to a delay in diagnosis. As a matter of fact, subactue metacarpal osteomyelitis is usually missed at the first time, so that some complications may occur like brachymetacarpia or loss of motion. We report a 10 year-old boy, with a subacute metaphyseal osteomyelitis of the second right metacarpal bone. The radiological features can mimic various benign or malignant bone tumours and non-pyogenic infecti...
Open Access DOI:10.23937/2469-5726/1510028
Massive Serositis as the Initial Presentation of Systemic Lupus Erythematosus: A Report of Two Cases and Review of the Literature
Laura Geraldino-Pardilla Yevgeniya Gartshteyn and Fabian Mendoza
Article Type: Case Series | First Published: December 31, 2015
Large volume effusions as a manifestation of active systemic lupus erythematous (SLE) is rare, and when it does occur, it is usually associated with complications of chronic lupus disease, such as nephrotic syndrome, constrictive pericarditis, heart failure or Budd-Chiari syndrome. Massive serositis as a presenting feature of SLE is rare. We describe two adult cases of new onset SLE presenting with massive ascites in the first case, and large bilateral pleural effusions in the second case. The s...
Open Access DOI:10.23937/2469-570X/1410018
Mammary Epithelial Cell Lineage Analysis via the Lyon's Hypothesis
Andrea L. George and Gilbert H. Smith
Article Type: Case Report | First Published: January 03, 2016
Implants of mammary glands from a single mammary fat pad in a H253 transgenic female mouse heterozygous for a lacZ-labeled X chromosome were analyzed at various time points following transplantation into the epithelium-cleared mammary fat pads of immune-compromised mice. The results show that the lacZ-marked X chromosome, demonstrated by nuclear-associated X-gal staining, was confined to a single epithelial clone that gave rise to the cap cells of all growing terminal end buds (TEB) in the expan...
Open Access DOI:10.23937/2469-570X/1410016
Regulation of Normal Somatic Cell and Cancer Cell Reprogramming by p53
Jie Yuan and Qin Yang
Article Type: Review Article | First Published: December 24, 2015
Reprogramming healthy somatic cells into disease-relevant cell types through cellular reprogramming has been intensively investigated. The discovery of reprogramming methods holds the promise of generating desired cells for disease modeling, drug screening studies and treatment of numerous diseases. Recently studies also focus on different disease cell reprogramming, including cancer cell reprogramming. Reprogramming and tumorigenesis share many similarities and the tumor suppressor p53 suppress...