Open Access DOI:10.23937/2474-3658/1510016

A Systematic Review of Efficacy Outcomes Reported from Clinical Trials Evaluating Vaccine Candidates Targeting Plasmodium Falciparum

James D MacKinnon

Article Type: Systematic Review | First Published: August 15, 2016

Malaria remains one of the most destructive communicable diseases worldwide. In the campaign towards global malaria eradication, the development of effective vaccinees has become paramount with the emergence of anti-malarial drug resistance to primary treatment and prophylactic regimens. Of particular focus are vaccinees specific to Plasmodium falciparum....

 Open Access DOI:10.23937/2572-3278.1510017

A New Whey Cheese Analogue Made from Whey Protein Concentrate and Vegetable Fat with 15% Olive Oil

Evangelia Zoidou, Ioanna Andreadaki, Theophilos Massouras and Stelios Kaminarides

Article Type: Research Article | First Published: August 27, 2016

Imitation cheeses or cheese analogues are cheese-like products in which milk fat, milk protein or both are partially or wholly replaced by non milk-based components to produce a specific cheese variety. They are manufactured by blending various edible fats/oils, proteins, other ingredients and water into a smooth homogenous blend with the aid of heat, mechanical shear and emulsifiers....

 Open Access DOI:10.23937/2572-3278.1510016

Enteral Nutrition in Intensive Care Units: Factors that Hinder Adequate Delivery

Mohamed Ezz El-Regal, Mohamed Abo Saba Abdelgawad, Nadia Taha Mohamed, Hayam Ibrahim Asfour and Nawal El Sayed Abd El-Rehim

Article Type: Research Article | First Published: July 26, 2016

Enteral nutrition (EN) is the most efficient nutritional support (NS) method in the intensive care units (ICUs). It has gained popularity over other methods in terms of promoting patient's immunity and enhancing better clinical outcomes in addition to its cost effectiveness. However, delivery of EN remains inadequate due to interruptions for various reasons, some of which are avoidable. Frequent interruptions may impact provision of nutrients and therefore, patient's clinical outcome. The aim of...

 Open Access DOI:10.23937/2572-4053.1510011

Sleep Habits and Excessive Daytime Sleepiness in a Population of Spanish Health Care Employees

Meritxell Espuga, Maria Antonia Ramon PT, Alfons Ayora, Manuel Alonso, Gabriel Sampol, Guadalupe Silveira and Patricia Lloberes

Article Type: Research Article | First Published: July 28, 2016

The aim of the study is to assess the sleep habits and prevalence of excessive daytime sleepiness (EDS) in Spanish health care workers and the relationship between sleep habits, EDS, anthropometric measurements, work shift, sleep apnea risk, and work commute traffic accidents....

 Open Access DOI:10.23937/2572-3987.1510007

Insight from 'Calcium Paradox' due to Ca2+ / cAMP Interaction: Novel Pharmacological Strategies for the Treatment of Depression

Leandro Bueno Bergantin and Afonso Caricati-Neto

Article Type: Review Article | First Published: September 12, 2016

Depression is a psychiatric disease resulting mainly by dysfunction of monoaminergic neurotransmission in central nervous system. Depression is a severe global illness, becoming more and more common each decade. Because of specific symptoms, it is considered as a leading cause of disability all over the world with a high death factor due to suicides. There are many antidepressants used in the therapy, but still more than one-third of patients do not respond to the current therapy....

 Open Access DOI:10.23937/2572-3987.1510006

Unacceptable Intravenous Administration of Chloral Hydrate Oral Solution

Turgay Cokyaman, Omer Ertugrul, Haydar Ali Tasdemir and Ayhan Dagdemir

Article Type: Case Report | First Published: August 04, 2016

Chloral hydrate is very frequently used in medical procedures with the purpose of sedation. After oral or rectal administration, central nervous system (CNS) and respiratory depression, cardiac arrhythmia and gastric irritation are known as classical adverse effects. Although the adverse effects developing after enteral usage are well known, there are limited data in literature about the misuse of chloral hydrate oral solution intravenously and the adverse effects that may be seen after this usa...

 Open Access DOI:10.23937/2377-9004/1410094

Supraclavicular Lymph Node as a Presentation of Fallopian Tube Cancer

Mohamed Satti, Ahmed Abdelaziz, Pouya Abhari and Guy Boike

Article Type: Case Report | First Published: September 01, 2016

A 44-year-old female presented with a large firm mass involving the left side of her neck; she denied any other symptoms. A CT scan was performed which was consistent with a 5.9 cm left-sided neck mass. A fine needle aspiration biopsy was consistent with poorly differentiated adenocarcinoma, and a serum CA125 was normal. Subsequently, a PET scan was performed and revealed increased uptake in the para-aortic and retroperitoneum lymph nodes; a soft tissue mass was seen in the left hemi-pelvis....

 Open Access DOI:10.23937/2377-9004/1410093

Breus Mole: A Placental Anomaly in a Patient Undergoing a Dilation and Evacuation

Navdeesh Reiners, Victor Sai, Nagesh Ragavendra, Aparna Sridhar and Angela Chen

Article Type: Case Report | First Published: August 06, 2016

A 22-year-old woman presented at 21+1 weeks for dilation and evacuation. Sonographic features were consistent with a Breus mole. Intraoperatively, traction and massage were used to deliver the placenta; the patient quickly achieved hemostasis. Final pathology showed a fibrin lined intervillous cystic structure compatible with a Breus mole....

 Open Access DOI:10.23937/2572-3286.1510012

Does Pre-Eclampsia Predispose Patients to the Development of Focal Segmental Glomerulosclerosis? 'The Chicken or the Egg?'

Nicole Lioufas, Jonathan Ling, Juli Jaw, Mathew Mathew, Matthew Jose and Richard Yu

Article Type: Case Series | First Published: August 31, 2016

Pre-eclampsia is the most common medical complication of pregnancy affecting 3-5% of pregnancies worldwide. Traditional teaching has generally maintained that the natural history of Pre-eclampsia is one of resolution of renal pathology and other clinical features- some days to weeks after delivery of the placenta. Renal injury is mediated by both endothelial and podocyte injury in pre-eclampsia. In some women however, the renal injury does not resolve and proteinuria persists following pregnancy...

 Open Access DOI:10.23937/2474-3631/1510021

Food Addiction: A Short Review

Amanda Caroline Cardoso Correa Carlos Menezes and Fabiana Goncalves Ferreira

Article Type: Short Review | First Published: August 13, 2016

Neurotransmitters are essential for humans' body to work properly. There is a hedonic brain circuit composed of centers that work together to enable these neurotransmitters to control the state of pleasure: dopamine and serotonin. All drug abuse increases dopamine levels in the extracellular medium. Several times dependence occur behaviorally, and in a less proportion by substance. On this review is going to be approached food addiction....