Open Access DOI:10.23937/2378-346X/1410065
Visual and Functional Outcome of Pediatric Bilateral Cataract Surgery with Intraocular Lens Implantation in Rwanda
Stefan De Smedt, Ildephonse Ngabonziza, Niko Speybroeck, Yannick Fonteyne, Jean Baptiste Minani, Piet Noe, Susan Buergi, M Edward Wilson and Rupal H Trivedi
Article Type: Research Article | First Published: December 01, 2016
Surgical, pre-, and postoperative data of bilateral pediatric cataract surgery cases performed between 1999 and 2007 were collected from the notes. During a prospective follow-up visit in 2008 full eye examination was done, including best corrected visual acuity (BCVA) assessment and refraction. Functional vision in daily life was assessed using a questionnaire....
Open Access DOI:10.23937/2378-3001/3/6/1060
The Damaging Impact of Chronic Heart Failure on A Critical Interoreceptor and the Therapy for it
Robert S Fitzgerald
Article Type: Mini Overview | First Published: December 01, 2016
Congestive Heart Failure (CHF) is among the heart diseases which accounted for > 54% of deaths world-wide in 2013 in a World Health Organizations report. CHF patients most often have a more sensitized carotid body (CB) chemoreceptor than normal. CB neural output stimulates output from the sympathetic nervous system. Increased CB output in CHF has in animal models been attributed to a loss of shear stress on the luminal surfaces of the CBs' vascular endothelial cells....
Open Access DOI:10.23937/2378-3001/3/6/1059
Abnormal Plasticity and Epigenesis in Epileptic Seizures of an EL Mouse
Jiro Suzuki
Article Type: Rather Short Review | First Published: November 30, 2016
The EL mice were exposed to the natural proprioceptive sensory stimulation of tossing the animal into the air to provoke an epileptic seizure, which results from an increase in the excitability of the cortical neurons due to low activities of Glutamic acid decarboxylase (GAD) and Gamma-amino butyric acid (GABA). The seizures develop due to the abnormal plasticity and eventually occur spontaneously....
Open Access DOI:10.23937/2378-3001/3/5/1058
Stroke is a Risk Factor for Fracture-A 17-Year Follow-Up Study in Men and Women
Penelope Trimpou, Anders Lindahl, Goran Olerod, Per-Olof Hansson, Anders Oden, Lars Wilhelmsen and Kerstin Landin-Wilhelmsen
Article Type: Original Article | First Published: October 07, 2016
A prospective study was performedof arandom population sample (n = 1616) in Gothenburg, Sweden; 746 men and 870 women, aged 25-64 years in 1995, from the WHO MONICA Project. Fractures were verified by X-ray, CVD events by medical records and lifestyle factors and medical treatment via a questionnaire. Quantitative Calcaneal Ultrasound (QUS) examinations were performed. Fasting blood samples were taken, and in fertile women also on cycle day 7-9....
Open Access DOI:10.23937/2378-3419/3/5/1070
Validation of Measurement Based Dose Volume Metrics for the Quality Assurance of VMAT Plans
Sankar Arumugam, Aitang Xing, Tony Young, David Thwaites and Lois Holloway
Article Type: Research Article | First Published: October 22, 2016
Ten each of prostate and head and neck (H&N) VMAT plans were considered for this study. Three types of errors were introduced into the original plans: gantry angle independent and dependent MLC errors, and gantry angle dependent dose error. The percentage difference in PTV-D95 between TPS and 3DVH was compared for no-error and error introduced plans....
Open Access DOI:10.23937/2378-3419/3/5/1069
A First Case of Male Breast Cancer Responding to Combined Aromatase Inhibitor/Palbociclib Therapy
Steven Sorscher
Article Type: Case Report | First Published: October 19, 2016
For men with metastatic breast adenocarcinoma standard therapies typically involve the same therapies used for woman. Recently the FDA approved the aromatase inhibitor letrozole combined with the inhibitor of cyclin dependent kinase 4/6 (CDK4/6) palbociclib as first line therapy for women with metastatic breast cancer. Here we report a first case of a man with metastatic breast cancer whose tumor responded to palbociclib and letrozole. This combination might be effective for other men with metas...
Open Access DOI:10.23937/2572-4142.1510003
The Transactional Nature of Human Healthcare
Lloyd Reeve-Johnson
Article Type: Review Article | First Published: December 07, 2016
The quality of healthcare, drug innovation, treatment decisions and even approval of drugs are all transaction dependent. Each decision after we seek medical attention is part of a predictable sequence, the totality of which describes the healthcare system. The interplay between the patient, clinician, pharmaceutical company, government or medical insurances paying bills, and, regulators controlling access to the healthcare market is therefore predictable and open to influence. Each of participa...