Open Access DOI:10.23937/2378-3656/1410147

The Use of Macitentan in the Treatment of Out-of-Proportion Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease: Case Report

Luca Fallavollita, Paolo Spinaci and Pietro Scendoni

Article Type: Case Report | First Published: December 14, 2016

Pulmonary hypertension (PH) is an important complication of chronic pulmonary disease, especially of chronic obstructive lung disease (COPD). The exact prevalence of PH in COPD is unknown. PH is defined as an increase in mean pulmonary arterial pressure (PAPm) > 25 mmHg at rest as assessed by right heart catheterization. In most cases, PH in COPD patients is usually mild to moderate. Only a small proportion of this cohort may present with severe pulmonary hypertension....

 Open Access DOI:10.23937/2378-3656/1410146

A Case of Pyonephrosis of an Obstructed Atrophic Kidney

Fareeha Khan, Rasha Nakhleh and Theodore Suh

Article Type: Case Report | First Published: December 12, 2016

This case is of a 67-year-old male who presented to the office with multiple symptoms and was treated for a variety of infections before the correct diagnosis of pyonephrosis in the setting of chronic ureteropelvic junction (UPJ) obstruction was made....

 Open Access DOI:10.23937/2469-5734/1510037

Human Papillomavirus Infection in Pregnant Adolescentes: Is There an Association Between Genital and Mouth Infection?

Cavalcanti, Silva, Ferreira, Neves, Vanderborght, Luiz and Torres

Article Type: Research Article | First Published: December 12, 2016

The microarray assay was more sensitive to detect HPV infection in the cervix, when compared to clinical exam and cytological analysis. There was no association of the HPV infection in the genitalia and the mouth, in the studied population of pregnant adolescents....

 Open Access DOI:10.23937/2378-3672/1410025

Non-Specific Vaccination Exerts Anti-Tumor Effect through CD11c (+) Cells Stimulation in a Breast Cancer Model

Vanessa Elizabeth De Gregorio, Silvia Carino, Juan Carlos Valdez, Silvio Eugenio Castillo and Alejandra de Moreno de LeBlanc

Article Type: Research Article | First Published: December 07, 2016

A non-specific vaccine used as immunotherapy can be used to prolong an equilibrium phase in the tumor growth, similar to the doxorubicin treatment used in the model, although by different mechanisms. Non synergic effect was observed in the group treated with both vaccine and doxorubicin (low dose). Future studies should be necessary to evaluate the correct combination of vaccination and cytotoxic drug can be used for this purpose and to achieve increased activated dendritic cells in the tumor d...

 Open Access DOI:10.23937/2474-1353/1510043

Knowledge and Use of Folic Acid among Women Attending the high-Risk Prenatal Clinics at the Adults University Hospital in Puerto Rico

Stephanie Rivera-Segarra, Lizzie Ramos-Tollinchi, Natalia Cardenas-Suarez and Josefina Romaguera

Article Type: Cross-sectional Descriptive Study | First Published: December 14, 2016

Pregnancies affected with neural tube defects (NTDs) are mostly associated to maternal deficiency of folic acid (FA). Although supplementation is recommended for all women of childbearing age, the incidence of NTDs in Puerto Rico has not shown a significant decrease....

 Open Access DOI:10.23937/2474-1353/1510042

Breast Cancer Screening Program in Jeddah, Saudi Arabia: Is There a Need for a National Program?

Muna M Baslaim, Iman H Baroum, Budoor A Salman, Basma S Baghlaf, Muayad A Al-Farsi and Nada M Ghouth

Article Type: Research Article | First Published: December 12, 2016

A national screening program for breast cancer in Saudi Arabia is well accepted by the society. Healthcare providers of all specialties need to be oriented with the importance of public awareness and the impact of screening. A well-structured screening program tailored to the local parameters may help discover breast cancer cases at an early stage. ...

 Open Access DOI:10.23937/2469-5750/1510040

Case of Angiolymphoid Hyperplasia with Eosinophilia Associated with Anti-TNF Inhibitor

Neeraj Singh, Britta Sundquist and Prashant Kaushik

Article Type: Case Report | First Published: December 14, 2016

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign condition featuring nodular or papular lesions of the dermis, subcutaneous tissue, and adjacent lymph nodes, commonly affecting the head and neck. The etiology is unknown, but case reports have thus far demonstrated an idiopathic origin. We describe here a case of ALHE occurring as an adverse effect of anti-tumor necrosis factor-alpha (TNF-α) inhibitor use, which has not previously been reported. An 81-year-old man with a ...

 Open Access DOI:10.23937/2378-3001/3/6/1063

Effectiveness of A Fall Prevention Protocol for Patients with Ischemic Stroke During Hospitalization

Yanxia Huang, Ting Luo, Lihui Huang, Lei Zhang, and Hongmei Tao

Article Type: Original Research | First Published: December 15 2016

Patients with ischemic stroke are at high risk of fall. However, few study focused on fall prevention for patients with ischemic stroke in hospital. The aims of the study were to find out the causes of falling in the inpatient ischemic stroke patients and formulate a fall prevention protocol for them....

 Open Access DOI:10.23937/2378-3001/3/6/1062

A Combinatory Therapy Continuously Improves Memory in a Case of Probable Alzheimer's Disease with Head Trauma for Nearly Two Years

Jing Shi, Xuekai Zhang, Mingqing Wei, Jingnian Ni, Ting Li Mphil and Jinzhou Tian

Article Type: Case Report | First Published: December 05, 2016

Since the worldwide demographic ageing, prevalence of the most common cause of dementia in the elderly, Alzheimer's disease (AD), will increase dramatically. Although it has been intensively researched for many years, there are still limited treatments for AD. Currently approved pharmacotherapy is generally considered have symptom-relieving rather than disease processing modifying effects. Meanwhile, there are efficacy limits of such medicines, for example, donepezil efficacy starts to decline f...

 Open Access DOI:10.23937/2378-3001/3/6/1061

Depression in Parkinson's Disease is Associated with a Serotoninergic System Change Secondary to Neuroinflammation

Ronise M Santiago, Maria ABF Vital, Marcelo D O Sato and Gustavo P Adam

Article Type: Research Report | First Published: December 03, 2016

Depression is a common psychiatric disorder in patients with Parkinson's disease (PD), being more prevalent in PD than in any other chronic disabling disease. Its cause, nevertheless, has not yet been elucidated. According to some authors, there is a decrease in serotonin (5-HT) levels compensatory to dopaminergic release impairment, but new evidence suggests that chronic inflammation may be a more likely etiogenic factor to depression. The inflammatory hypothesis states that depression is cause...