Open Access DOI:10.23937/2378-3397/1410054
Wirsung Duct Occlusion Versus Pancreaticojejunostomy after Pancreaticoduodenectomy
Claudio F Feo, Alessandro Fancellu, Giorgio C Ginesu, Maria Laura Cossu, Antonio M Scanu, Antonio Pinna, Panagiotis Paliogiannis and Alberto Porcu
Article Type: Research Article | First Published: April 03, 2017
Postoperative pancreatic fistula is still a cause of major morbidity after pancreaticoduodenectomy. The optimal management of the pancreatic remnant is still controversial. Our aim was to analyze the role of two different procedures in the management of pancreatic stump in a single surgical unit....
Open Access DOI:10.23937/2378-3397/1410053
Gender Differences in Left Ventricular Assist Device (LVAD) Support
Sneha Raju, Morgan Leigh Zych, Jane MacIver, FilioBillia and Vivek Rao
Article Type: Case Report | First Published: April 03, 2017
Studies have demonstrated gender differences in adverse events after cardiac surgery, with men experiencing more favorable outcomes. The scarce gender-focused literature in the left ventricular assist device (LVAD) population has failed to find consistent differences. It has also been suggested that women experience longer transplant wait times due to higher PRA values....
Open Access DOI:10.23937/2378-3397/1410051
The Surgical Checklist Revisited
Caroline Daggett BA and Amanda Daggett MD
Article Type: Case Report | First Published: February 27, 2017
It is estimated that in-hospital adverse surgical events occur in the range of 3 to 17%. This paper reviews the use of surgical checklists as a tool for reducing preventable errors. It uses the work of Dr. Peter Pronovost, Dr. Atul Gawande, and the World Health Organization (WHO) to revisit the evidence-based proof that checklists do work in the right setting and under the right circumstances....
Open Access DOI:10.23937/2469-5696/1410025
Polycomb Proteins in Hematopoiesis and Hematologic Malignancie
Jie Li
Article Type: Review Article | First Published: March 20, 2017
In recent years, the Polycomb group (PcG) of proteins has been revealed to be involved in the regulation of hematologic stem cell function and differentiation and have been broadly linked to hematologic malignancies. Polycomb proteins are histone modifiers that contain two multi-protein complexes: Polycomb Repressive Complex 1 and 2 (PRC1 and PRC2)....
Open Access DOI:10.23937/2474-3658/1510028
Features and Prognostic Factors of Tuberculous Meningitis in a Tertiary Hospital in Malaysia
Chia Peck Kee, Petrick Periyasamy, Zhe Kang Law, Norlinah Mohamed Ibrahim, Wan Nur Nafisah WanYahya, Hazlina Mahadzir, Shahrul Azmin Md Rani, Ramesh Sahathevan, Rabani Remli, Raymond Azman Ali, Hui Jan Tan, Syazarina Sharis Osman, Shahizon Azura Mohamed Mukari and Shamsul Azhar Shah
Article Type: Research Article | First Published: March 17, 2017
Tuberculous meningitis (TBM) has been one of the major extrapulmonary manifestation with high morbidity and mortality. This paper aims to study the clinical features, prognostic factors and clinical outcome of TBM in a local tertiary hospital. This was an observational study on TBM in patients who were diagnosed in a local tertiary hospital....
Open Access DOI:10.23937/2474-3658/1510027
A Meta-Analysis of Directly Observed Treatment vs. Self- Administered Therapy Outcomes in Pulmonary Tuberculosis Patients
Ardigleusa Alves Coêlho, Ricardo Ney Oliveira Cobucci, Emannuela Maria Nunes Freitas, Paulo Henrique Lima, Ewerton Willian Gomes Brito, Tânia Maria Ribeiro Monteiro de Figueiredo, Ana Katherine da Silveira Gonçalves and Severina Alice da Costa Uchoa
Article Type: Research Article | First Published: March 10, 2017
A systematic review and meta-analysis were conducted in order to compare the effectiveness of directly observed therapy, short-course (DOTS) with self-administered treatment (SAT) in people with pulmonary tuberculosis. PubMed, Embase, ISI Web of Science, and the Scielo/Lilacs were searched for studies published between 1 January 1965 and 31 December 2013....
Open Access DOI:10.23937/2474-3658/1510026
Building Surveillance Capacity: Lessons Learned from a Ten Year Experience
Pamela J Kennedy, Sajata Outin, Tomas R Rodriguez, Lauren Polansky, Margaret McCarron and Karen R Siener, Ann C Moen
Article Type: Review Article | First Published: March 08, 2017
As Global Health Security partners endeavor to support capacity building globally, it is important to examine prior efforts for building surveillance and laboratory systems for emerging infectious diseases. CDC provides financial support and technical assistance to foreign governments for the development or improvement of influenza surveillance networks in over fifty countries through cooperative agreements....
Open Access DOI:10.23937/2474-3658/1510025
The Intestinal Microbial Community and Inflammatory Bowel Diseases
Hubert E Blum
Article Type: Review Article | First Published: March 06, 2017
Based on molecular, genetic, epigenetic, biochemical and microbiological analyses it is increasingly possible to identify individual disease-related characteristics that define disease pathogenesis, disease disposition or prognosis as well as the efficacy of therapeutic strategies (personalized medicine/precision medicine')....