Open Access DOI:10.23937/2572-3243.1510049

Oral Ibuprofen Interferes with Cellular Healing Responses in a Murine Model of Achilles Tendinopathy

Adam Bitterman, Shuguang Gao, Sabah Rezvani, Jun Li, Katie J Sikes, John Sandy, Vincent Wang, Simon Lee, John Holmes, Johnny Lin and Anna Plaas

Article Type: Original Research | First Published: May 21, 2018

The attempted healing of tendon after acute injury (overloading, partial tear or complete rupture) proceeds via the normal wound healing cascade involving hemostasis, inflammation, matrix synthesis and matrix remodeling. Depending on the degree of trauma and the nature of the post-injury milieu, a variable degree of healing and recovery of function occurs....

 Open Access DOI:10.23937/2469-5858/1510043

Health-related Quality of Life and Muscle Functions among Pre-frail Elderly Outpatients: Stronger Correlation with Gait Speed than Handgrip Strength

Purwita Wijaya Laksmi, Siti Setiati, Tirza Z Tamin, Pradana Soewondo, Wasilah Rochmah, Nafrialdi and Joedo Prihartono

Article Type: Original Article | First Published: May 21, 2018

Frail elderly has an increased risk of having debilitating health outcomes that lead to poor health-related quality of life (HR-QoL). The central manifestation of frailty syndrome is the muscle functions. The aim of this study was to evaluate the correlation between muscle functions and HR-QoL among pre-frail elderly outpatients....

 Open Access DOI:10.23937/2378-3516/1410079

Fibrosing Mediastinitis: A Review of Epidemiology, Diagnosis and Management

Abraham O Kuranga, Andrea M Eubank and Mark R Bowling

Article Type: Review Article | First Published: May 14, 2018

Fibrosing Mediastinitis (FM) is a rare but increasingly recognized complication that has been mainly associated with chronic pulmonary histoplasmosis, granulomatous diseases, infections and autoimmune processes. Symptoms vary depending on compromised structures, mainly structures within the mediastinum. This review will focus on the etiology, clinical presentation and management of fibrosing mediastinitis based on multiple case series published to date....

 Open Access DOI:10.23937/2378-3516/1410078

Different Perspective in Managing Airway Obstruction Secondary to Giant Tracheal Pyogenic Granuloma

YT Liew, KN Lorna Ting, AB Zulkiflee and N Prepageran

Article Type: Case Report | First Published: April 26, 2018

Pyogenic granuloma, or lobular capillary haemangioma is common in skin and mucosal surface such as oral cavity. It hardly occurs in tracheal mucosal, and even more rare to cause life threatening tracheal obstruction. Surgical excision is the mainstay of treatment with multidisciplinary support....

 Open Access DOI:10.23937/2474-1353/1510070

Uterine Rupture during Subsequent Pregnancy following Adenomyomectomy - Report of Five Cases and Proposal for Prevention

Masato Nishida, Yasuo Otsubo, Yuko Arai, Ryota Ichikawa, Yuzuru Kondo, Hiroya Itagaki and Miyako Sakanaka

Article Type: Research Article | First Published: May 19, 2018

The risk of uterine rupture is a major concern for women who become pregnant after undergoing an adenomyomectomy. The aim of this study was to investigate the mechanism of uterine rupture and improve the surgical procedure used for prevention....

 Open Access DOI:10.23937/2378-3397/1410069

Arterio-colonic Fistula as a Complication of Failed Pancreatic Transplant

Mantilla N, Calata J, Trepanier JS, Tzvetanov I, Nordenstam J, Chaudhry V and Mellgren A

Article Type: Case Report | First Published: May 19, 2018

Arterio-enteric fistulas are rare but feared complications after failed enterically drained pancreatic transplants. Massive and abrupt gastrointestinal bleeding is the cardinal presentation as a result of pseudoaneurysm rupture into the bowel lumen. However, subclinical presentation of delayed arterio-enteric fistulas may represent a diagnostic challenge for surgeons and warrants a high index of suspicion. Endovascular techniques have evolved as an excellent option as a bridge to definitive trea...

 Open Access DOI:10.23937/2378-3397/1410068

Granular Cell Tumor Involving the Anal Sphincter: A Case Report and Review of the Literature

Terrah J Paul Olson, Emily Steinhagen and Lisa M Cannon

Article Type: Case Report | First Published: May 19, 2018

Granular cell tumors are unusual, typically benign tumors deriving from Schwann cells. They can arise of tissues anywhere in the body and can rarely involve the perianal tissues. We discuss the case of a granular cell tumor involving the external anal sphincter....

 Open Access DOI:10.23937/2377-3634/1410088

Tropical Pyomyositis: Case Report

Sylvia Rannyelle Teixeira Lima, Joao Kennedy Teixeira Lima, Antonio Leonel de Lima Junior, Indira Ravena Pereira Alves Fernandes Macedo, Jaine Dantas Peixoto, Debora Laesia Sariava Ribeiro, Maria Mirelle Ferreira Leite Barbosa and Marcia Meyrilane de Alencar Aquino

Article Type: Case Report | First Published: May 19, 2018

The first case of pyomyositis was described by Scriba in the 19th century, being found endemically in tropical regions. Until recently, pyomyositis was considered uncommon in the temperate zone. Currently there is an increase in the number of cases of pyomyositis in temperate climates....

 Open Access DOI:10.23937/iaphcm-2017/1710008

Impact of Adherence to a Full Course of Intermittent Preventive Treatment of Malaria in Pregnancy on Pregnancy Outcome in Muyuka Health District: A Cross-Sectional Study

Aldof Tah Yoah, Jerome Fru-Cho, Emmanuel Kah, Ernest Njukang, Franklin Sevidzem Wirsiy, Christian Tetteh Duamor and Theresa Nkuo-Akenji

Article Type: Research Article | First Published: May 19, 2018

Malaria is an acute febrile disease caused by infection of the red blood cells with intracellular protozoan parasites of the genus Plasmodium. The parasites are inoculated into the human host by feeding female Anopheles mosquitoes. Malaria infection during pregnancy presents significant risks for the pregnant woman, the developing foetus and the newborn infant....

 Open Access DOI:10.23937/2572-3243.1510048

Bisphosphonates and MeCP2 Deficiency: Cellular Studies and Clinical Application in Rett Syndrome

Jay R Shapiro and Mary E Blue

Article Type: Short Note | First Published: May 18, 2018

In this Short Note, we assess what is known about the structural deficits in bone in Rett syndrome (RTT), a rare x-linked neurodevelopmental disorder and in mouse models of RTT and provide a rationale for the treatment of bone fragility observed in this disorder. RTT is caused by mutations in a gene that encodes for methyl CpG protein binding protein 2 (MeCP2), which can act as an inhibitor or activator of gene transcription. MeCP2 is ubiquitously expressed throughout the body....