Open Access DOI:10.23937/2378-3001/1410084
Prevention and Treatment of Basic Diseases: A Potential Direction to Intervene Alzheimer's Disease
Wei Jiangping and Xu Shijun
Article Type: Review Article | First Published: May 22, 2019
As the life span of human beings increases, the number of dementia patients such as Alzheimer's disease (AD) is increasing. AD may be one of the major diseases faced by the whole world in the future. It is an unresponsive for single drug according to the current stage of AD pathogenesis and drug research. Combined use of various drugs may be the inevitable trend of AD drug research in the future. Personalized treatment of metabolic diseases, vascular diseases and chronic inflammatory risk diseas...
Open Access DOI:10.23937/iavm-2017/1710002
Oxygen, the Link between Intracranial Aneurisms Disruption and the Atmospheric Environment?
Thierry Patrice
Article Type: LETTER TO EDITOR | First Published: May 22, 2019
The general purpose of research either clinical or basic is to describe links existing between an identified disease and its whole environment from the surrounding tissues and the patient, to his ecosystem. From this point of view berry aneurisms are extremely interesting: They develop from normal tissues, their cause is largely unknown, and their evolution is barely predictable but dramatic in case of disruption. Subarachnoid hemorrhage (SAH) from a ruptured aneurysm accounts for around 5% of a...
Open Access DOI:10.23937/2643-4466/1710013
Phases of the Diagnostic Journey: A Framework
Linda N Geng, Oliver Sum Ping and Yong-Jian Geng
Article Type: Commentary Article | First Published: May 20, 2019
Diagnostic journeys begin when patients first present to a healthcare provider for their symptoms and end when they receive the correct diagnosis for these symptoms. In many cases, the diagnosis can be made promptly, but patients with rare, complex, or unusual conditions often embark on odysseys spanning years to sometimes even decades in search of a diagnosis. This prolonged process can often result in excessive costs, preventable medical errors and iatrogenesis, as well as feelings of frustrat...
Open Access DOI:10.23937/2377-9004/1410146
Management of Fetal Supraventricular Tachycardia: Three Cases at a Single Institution
Rahel Ghenbot, MD, Veronica Gonzalez-Brown, MD and Kara Markham, MD
Article Type: Case Report | First Published: May 18, 2019
Fetal tachycardia complicates 1-2% of pregnancies, and a large percentage of these arrhythmias are supraventricular. Sustained fetal tachycardia can have serious complications for the fetus, including cardiovascular failure, nonimmune fetal hydrops, and fetal death. Management of fetal tachycardia depends on multiple factors. Here we present three different cases of fetal supraventricular tachycardia (SVT) and their management at a single institution....
Open Access DOI:10.23937/2469-5807/1510089
Adult Glioblastoma and the Role of DAXX (Death Domain Associated Protein) Tumor Biomarker
Sean M Hacking, Cao Jin, Seungjun Ahn, Deepika Savant and Mansoor Nasim
Article Type: Retrospective Study | First Published: May 18, 2019
Glioblastoma, also known as glioblastoma multiforme (GBM), is the most aggressive primary brain cancer. GBM comprises 16% of all primary brain neoplasms with an incidence rate of 3.2 per 100,000 people. Patients with GBM have a poor prognosis, less than 5% of them survive for more than 5 years. In the treatment of GBM there is currently insufficient information to improve disease management because conventional treatments universally fail. Currently there is a crucial need to identify relevant t...
Open Access DOI:10.23937/2469-5750/1510072
Lupus Miliaris Disseminatus Faciei Treated By Isotretinoin and Platelet Rich Plasma
A Lahrichi, F Hali, K Baline, F Marnissi and S Chiheb
Article Type: Case Report | First Published: May 17, 2019
An 18-year-old patient presented with lupoid papulonodular lesions in the face. The diagnosis of disseminated lupus of the face was retained after eliminating other diagnoses including sarcoidosis, syphilis and leprosy. An antibacillary treatment was started without improvement for 3 months with onset of lesions. A 0.5 mg/kg/day isotretinoin treatment was started with improvement of the lesions. Thereafter, the patient benefited from 6 sessions of injection of platelet-rich plasma (PRP) with sag...
Open Access DOI:10.23937/2378-3516/1410107
An Investigation of Various Inspiratory Times and Inflation Pressures during Airway Pressure Release Ventilation
Tim W Gilmore, Robert E Walter, Patrick C Hardigan, Clifton F Frilot II and Guy M Nehrenz
Article Type: Original Research Article | First Published: May 16, 2019
There are few recommendations how best to apply certain modes of mechanical ventilation, and the application of Airway Pressure Release Ventilation (APRV) requires strategic implementation of specific inspiratory (I-time) and expiratory times (E-time) and particular mean airway pressures (MAWP), neither of which is standardized. We sought to identify whether an ideal I-time or MAWP could be identified to favor more positive clinical outcomes. A retrospective analysis of archived electronic healt...