Open Access DOI:10.23937/2378-3656/1410272
Basal-Like Breast Cancer: Main Features of a Very Particular Entity of Breast Cancer
Haddad S, Zemni I, Bettaieb I, Adouni O, Saadallah F, Slimane M, Chargui R and Rahal K
Article Type: Case Series | First Published: June 14, 2019
Molecular classification of breast cancer identified the basal like subtype, characterized by high heterogeneity and a very poor prognosis. These tumors are mainly triple negative, characterized by the expression of basal markers: CK5/6 and EGFR. In this study, we sought to investigate the features, outcome and therapeutic modalities of basal-like breast cancers (BLBC)....
Open Access DOI:10.23937/2474-3682/1510134
Hemophagocytic Lymphohistiocytosis
Nwabundo Anusim
Article Type: IMAGE ARTICLE | First Published: June 20, 2019
A 66-year-old male with a history of sarcoidosis, chronic kidney disease, hodgkin's and non-hodgkin's lymphoma presents with shortness of breath and lethargy after failing outpatient treatment of an upper respiratory tract infection. White count on admission was 2.6 (3.5 -10bil/l), with normal absolute neutrophil count (ANC) and hemoglobin was 9.9 (13.5-17 g/dl). During the course of his admission, he was found to have a fever of 101.5 and progressive pancytopenia {ANC 0.9 (1.6-7.2 bil/L)....
Open Access DOI:10.23937/2474-3682/1510133
Cobra Head Sign
Yih Chyn Phan and Wasim Mahmalji
Article Type: IMAGE ARTICLE | First Published: June 20, 2019
A 62-year-old man was referred by his general practitioner to the urology outpatient clinic as his routine blood test showed a raised prostate-specific antigen (PSA) of 10 ug/l. On further questioning, he has minimal lower urinary tract symptoms and there was no symptom to suggest that he had a urinary tract infection recently. Examinations of his abdomen and male genitalia including a digital rectal examination were normal. As recommended by the latest National Institute for Health and Care Exc...
Open Access DOI:10.23937/2378-2951/1410151
Prevalence and Clinical Correlates of Spontaneous Echo Contrast in Patients on Oral Anticoagulation Undergoing Catheter Ablation for Atrial Fibrillation
Christian Grebmer, Carsten Lennerz, Amir Brkic, Patrick Blazek, Severin Weigand, Verena Semmler, Marc Kottmaier, Felix Bourier, Lena Friedrich, Elena Risse, Stephanie Brooks, Marie Kornmayer, Marta Telishevska, Tilko Reents, Christof Kolb, Gabriele Hessling and Isabel Deisenhofer
Article Type: Research Article | First Published: June 19, 2019
Spontaneous echo contrast (SEC) in the left atrial appendage (LAA) is associated with an increased risk of cerebral embolism in patients with atrial fibrillation (AF). Novel oral anticoagulants (NOACs) are increasingly prescribed as first-line therapy and have shown a comparable benefit-risk ratio compared to vitamin K antagonists (VKAs). The aim of this study was to investigate whether NOACs decrease the incidence of SEC compared to VKA. ...
Open Access DOI:10.23937/2378-2951/1410150
Unroofed Coronary Sinus Syndrome Presenting with Early Pulmonary Hypertension
Maria E Franco-Fuenmayor, MD, Numra A Aleem, MD, Jorge D Salazar, MD, and Ashraf M Aly, MD
Article Type: Case Report | First Published: June 13, 2019
Isolated partial or complete absence of the coronary sinus roof hemodynamically behaves like an atrial septal defect and rarely causes pulmonary hypertension. We report a case of unroofed coronary sinus (URCS) presenting with post-operative cyanosis due to pulmonary hypertensive crisis following surgical repair of a ventricular septal defect at 6 months of age. He had progressively decreased stamina with gradual increase in pulmonary pressure requiring surgical closure of the URCS by 6 years of ...
Open Access DOI:10.23937/2378-3656/1410271
Case Report: Necrotizing Fasciitis due to Cryptococcus Infection in Non-HIV Non-Organ Transplant
Rbab Taha, Mohamed Alama, Hessa Aljhdali, Ayaz khan and Reham Kaki
Article Type: Case Report | First Published: June 12, 2019
We are presenting 67-year-old female, known to have diabetes for 10 years, not compliance to medication. Presented with 3 weeks history of isolated right lower limb and left thigh pain. Then she started to develop redness and swelling in same areas. She had also History of dry cough for one week. Admitted as a case of necrotizing fasciitis based on clinical laboratory and radiological features. She was treated empirically with vancomycin and meropenem and went for debridement twice. Histopatholo...
Open Access DOI:10.23937/2572-4053.1510022
Novel Anti-Snoring Mouthpiece to Reduce Snoring in At-Home Study
Jonathan Greenburg, DDS, Jesse Cozean, MBA and Colette Cozean, PhD
Article Type: Clinical Trial | First Published: June 10, 2019
Habitual snoring affects millions of individuals and their partners, but often goes unresolved due to the high cost of care and other barriers to treatment. The purpose of this study was to evaluate the effectiveness of a novel intraoral device that restrains the tongue in an overthe- counter setting in a population of habitual snorers. Individuals who self-reported snoring enrolled in the study and were sent an investigational device. After signing the informed consent, they completed an initia...
Open Access DOI:10.23937/2378-3672/1410036
S-Nitrosoglutathione Modulates Expansion of Activated CD4CD25 Cells by Apoptosis under Inflammatory Condition
Subhajit Dasgupta
Article Type: Research Article | First Published: June 08, 2019
The regulation checkpoints of CD4CD25 expansion in presence and absence of transcription factor FOXP3 are critical to maintain balance between inflammatory TH17 and anti-inflammatory FOXP3CD4CD25 Treg cells. We investigated impact of potent inflammatory mediator nitric oxide NO(.) on commitment of normal spleen T cells following activation. The single cell suspension of healthy C57BL/6 mice splenic CD4 cells was stimulated by plate-bound antiCD3/antiCD28 antibodies in presence of cytokine cockta...