Open Access DOI:10.23937/2378-3648/1410044
SVMOneClAS: Pipeline for Efficient Splicing Events Calling
Sokolov A, Mazur A, Zhigalova N, Prokhortchouk A, Gruzdeva N and Prokhortchouk E
Article Type: Research Article | First Published: June 05, 2019
Splicing is a part of mRNA maturation process when exons of pre-mRNA transcript are joined in multiple ways. In case of alternative splicing, some exons may be excluded from the final mRNA, and the resulting ensemble of mRNAs creates different protein isoforms, allowing multiple proteins to be coded by a single gene. To detect new events of alternative splicing in human blood cells, we used RNA-seq technology. A pipeline based on Python "Scikit-Learn" library was developed for efficient splicing...
Open Access DOI:10.23937/2469-5793/1510104
How to Establish a Medical Ethics or Bioethics Committee?
Angel Velarde, MD, MSCE and Erwin Calgua, MD, MSCE
Article Type: Research Article | First Published: June 28, 2019
From the review of the literature, it was found that the ethics committees must be composed of at least 5 members, who are nominated by the director of the institution, with at least one member in the scientific area, a member in an area not scientific and a member not affiliated with the institution and each member must conduct ethics courses. The duration of the period will be for 3 years, and continuity may be given when so determined. Of the conflicts of interest, it was found that the last ...
Open Access DOI:10.23937/2469-5793/1510103
Perspectives of Peers Experiences and Feeling About Termination of Pregnancy: A Focus Group Study in an Adolescent Population
Sunday Bassey Udoh, MBBS, FWACP, FMCFM, Victory Edet Iyanam, MBBS, FWACP and Oluyinka S Akinbami, MBBS, FWACP
Article Type: Research Article | First Published: June 27, 2019
Annually, over one million adolescent girls in Nigeria become pregnant. With active participation in decision making by their caregivers and peers, more than 60% of them end up in induced abortions. Generally, peers exert major social influence on adolescent sexual behavior by playing "role model" for others in their close contact. These "role models" are the first to be contacted when any problem such as unintended pregnancy occurs and most times they are involved in counseling as well as contr...
Open Access DOI:10.23937/2469-584X/1510066
Efficacy and Safety of Direct Acting Antivirals (DAAs) in an Urban Clinical Setting
Olga M. Klibanov, Delina Meskel, Chris Gillette and Tagbo J Ekwonu
Article Type: Research Article | First Published: June 21, 2019
This retrospective cohort included patients who initiated on DAAs between May 2014 and May 2018. The primary endpoint was SVR12. Descriptive statistics were used to analyze the results. Bivariate associations between patients achieving treatment success and demographic and clinical variables were conducted using chi-square, Fisher's exact test, and independent samples t-test with a two-sided alpha value of 0.05....
Open Access DOI:10.23937/2474-1353/1510098
Interventions for Pregnant Women against Malaria: A Mini Review
Ahmed Dahiru Balami, Salmiah Muhammad Said and NorAfiah Muhammad Zulkefli
Article Type: Review Article | First Published: July 03, 2019
Malaria remains highly endemic in sub-Saharan Africa, and about 25 million pregnancies are estimated to occur yearly in malaria-endemic regions of the sub-continent. Several interventions aimed at improving knowledge, attitude, and practice of malaria prevention, have been studied among different groups, only a few of which were among pregnant women. A systematic review of educational interventions in sub-Saharan Africa which included studies which focused on ITN, IPTp, home-based management and...
Open Access DOI:10.23937/2378-3397/1410102
Current Status and Future Prospects of Idebenone in Treatment of Mitochondrial Diseases: Literature Review
Hendi Maher, MD, Weiwei Zhang, Ke Chen, MD, Henry Davies and Xiujun Cai, MD
Article Type: Review Article | First Published: June 15, 2019
Idebenone (IDBN) is an antioxidant compound, structurally related to coenzyme Q10. It's therapeutic potential is growing in different areas. Over the two decades ago, for potential treatments of mitochondrial diseases have been suggested, relatively few have undergone controlled clinical trials. This review focuses on the recent history of manuscripts of idebenone, coenzyme Q10 and exercise in both primary disorders and secondary disorders. Despite prior clinical impressions that IDBN had a posi...
Open Access DOI:10.23937/2469-5718/1510133
The Great Difficulties for our Obese and Hypertensive Patients to have Physical Activities
N Ali-Tatar, A Derradji, R Guermaz, D Hakem, B Mohammedi, M Brouri, A Berrah and MT Chentir
Article Type: Research Article | First Published: June 21, 2019
A sedentary lifestyle and physical inactivity affects more than half of the population worldwide. Despite the burdens that obesity and diabetes impose on our society, awareness of the cardiovascular disease as a result, is poor. What about primary prevention of cardiovascular diseases in our population with obesity and diabetes? To investigate the feasibility in our daily practice of Cardiovascular (CV) primary prevention in Algerian patients without established cardiovascular disease....
Open Access DOI:10.23937/2469-5718/1510132
Proof of Concept: Taking the Guessing out of Assessing Knee Stability
Dawn Gulick
Article Type: Research Article | First Published: June 20, 2019
The Anterior Cruciate Ligament (ACL) is frequently assessed using the Lachman test. This test involves linear translation of the tibia on the femur. Meta-analysis and systematic reviews report a wide range of diagnostic accuracy. The purpose of this case report was to establish a proof of concept using a novel device, the Mobil-Aider, to accurately quantify linear translation of the tibia on the femur....