Open Access DOI:10.23937/2378-2951/1410187
Increased Incidence and Prevalence of Cardiovascular Events and Mortality in Female Patients with NAFLD: A Meta-Analysis and Meta-Regression
Yaser Khalid, DO , Neethi Dasu, DO, Herman Suga, DO, Kirti Dasu, BA, Debashis Reja, MD, Ankit Shah, DO, Donald McMahon, DO and Adam Levine, DO
Article Type: Meta-Analysis | First Published: July 10, 2020
Non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD) share similar risk factors. Recent studies have focused on obesity and insulin-resistance, but the link between NAFLD and CVD persists regardless of traditional risk factors. Despite the increased incidence and prevalence of NAFLD world-wide, there has been no thorough investigation of gender disparities nor a closer look taken into investigating the role gender may play in increased cardiovascular (CV) mortality inciden...
Open Access DOI:10.23937/2469-5831/1510028
Bridging Strategies for In Vitro Diagnostic Clinical Trials in a New Region
Robert Magari, PhD, Mohamad Hasan, PhD and Karen Lo
Article Type: Original Article | First Published: July 10, 2020
The need for multiregional clinical trials for in vitro diagnostic devices and extrapolating results in a new region is increasing in recent years. In this paper we are providing strategies for consideration of bridging studies for the two most common types of clinical trials for in vitro diagnostic, method comparison and diagnostic clinical performance trials. Bridging studies should be considered when the expected agreement in the new region is inferior to the agreement in the original trial. ...
Open Access DOI:10.23937/2690-3172/1710006
Bio-Psychologically Based Resilience Traits in a Group of Healthy Undergraduate Students: The Role of NRG1 Gene
Zsuzsanna Elek, Zsolt Rónai, János Réthelyi, Enikő Csilla Kiss, István Tiringer, Ernő Hupuczi, László Martin, János Kállai
Article Type: Research Article | First Published: July 25, 2020
The genetic predisposition for the psychological resilience has an essential role in the phenotype of adaptive and successful behavior, but the functional repertoire of bio-psychological bases for the adaptive personality growth is until uncompleted. Besides dopaminergic and serotoninergic system-related genes is required to reveal a new genetic target for understanding the potential biological mechanism of resilience. The object of this study was to examine the role of different genetic polymor...
Open Access DOI:10.23937/2469-5696/1410054
Influence of ABO Blood Group on Fibrinogen Levels and Platelet Count in Apparently Healthy Nigerian Subjects
Okeke CO and Iloka VC
Article Type: Original Article | First Published: July 25, 2020
A close association has been shown to exist between ABO blood type and the risk of some diseases with non-O (A, B, or AB) individuals having an increased differential disposition to thrombotic disorders. The present study evaluated the fibrinogen levels and platelet count in subjects of different ABO blood groups with the view of ascertaining if disparity exists in the levels of fibrinogen and platelet count amongst the different ABO blood groups....
Open Access DOI:10.23937/2377-4630/1410110
Palliative Therapy of Refractory Dyspnea with Low Dose Transdermal Applied Buprenorphine: An Observational Study
Fabian Rings, Sven Gottschling and Patric Bialas
Article Type: Original Article | First Published: July 18, 2020
Dyspnea is a distressing symptom of many terminal ill patients that has to be treated. Despite recent guideline recommendations there is still great restraint in using opioids for the treatment of dyspnea. In this report, we investigated, whether transdermal application of buprenorphine (TD BUP) is a safe and efficient way to treat dyspnea. Before applying BUP, dyspnea was scored on numerical analog scales and the patients were examined (assessment of vital parameters, questionnaires). Than trea...
Open Access DOI:10.23937/2469-5742/1510074
Post PCNL Renal Pseudoaneurysm and AV Fistula: Single Institution Analysis
Ajay Anand
Article Type: Original Article | First Published: July 18, 2020
PCNL has been accepted as a minimally invasive gold standard treatment for renal calculi. Though PCNL is a minimally morbid procedure yet it is fraught with rare but significant complication of post-procedural hematuria. Massive hematuria due to renovascular injury has been reported in 0.3-1% of patients following PCNL. Persistent hematuria can be life-threatening if not managed on emergency basis. Almost all renal punctures for PCNL are associated with vascular injury - some trivial and self-re...
Open Access DOI:10.23937/2643-4512/1710048
Mobile App Training and Informative Experience in Health Education
Ana Belén Sánchez-García, Eva Abad-Corpa and Juan José Rodriguez-Mondejar
Article Type: Research Article | First Published: July 10, 2020
A wide variety of studies have shown that new technologies facilitate the acquisition of knowledge and skills. New technologies were introduced into the nursing field in the mid-1960s with the advent of basic computer programs. In the 21st century, the use of mobile devices such as tablets, smart phones and PDAs has been introduced. Currently, gambling techniques and serious games are proposed and studied in nursing education....
Open Access DOI:10.23937/2643-4466/1710026
Comparison of Health Status between At-Home-Care and Institutionalized Adults with Down Syndrome in Japan
Kimiko Ueda, MD, MPH, PhD and Nobuhiko Okamoto, MD
Article Type: Research Article | First Published: May 02, 2020
In both cohorts, more than half of the subjects, regardless of gender, had dyslipidemia. Hyperuricemia and obesity were significantly more frequent in at-home-care men than in institutionalized men. The most common diseases in the institutionalized subjects were dyslipidemia (61%), ringworm (59.3%), hypothyroidism (30.5%), hyperuricemia (25.4%) and dementia (16.9%; 46% in those in their 60s). Subjects in their 50s or later showed a greater need for assistance in walking/moving, getting dressed a...
Open Access DOI:10.23937/2474-3682/1510146
A Rare Case of Idiopathic Petrified Ear or Calcified Pinna
Ranjit Meher, MBBS, MD, Varsha M Khalkho, MBBS, DNB, and Anwesha D Patel, MBBS, MDRD
Article Type: Image Article | First Published: July 23, 2020
Calcification or ossification of the auricular cartilage, also known as “petrified ears”, was first described by Bochdalek in 1866. In our article, a seventy-two years-old male was evaluated for stiffed left ear over few years. No obvious cause was demonstrated on laboratory tests. Calcification or ossification of the left external auricular cartilage was demonstrated on non-contrast temporal bone Computed Tomography (CT) scan and therefore a rare case of idiopathic petrified left ear was di...