Open Access DOI:10.23937/2377-4630/1410180
The Efficacy and Safety of Remimazolam versus Propofol in Patients Undergoing Colonoscopy: A Systematic Review and Meta-Analysis
Vitor Cavalcante Monici, Alessandra Rocha Ribeiro Souto, Henrique de La Rocque Vieira de Mello dos Reis1, Augusto Silva Alves, Ângelo Antônio Silva Lima, José Riccardo Ferrette Barreto, Igor Mourão Almeida, Henrique Augusto Guaresqui and Flavia Farah Sabe
Article Type: Systematic Review and Meta-Analysis | First Published: 2024/08/07
Anesthesia with Propofol is common in patients undergoing colonoscopy, however, Remimazolam, a ultra-short-acting benzodiazepine, emerges as an alternative for this procedure. There are no clear protocols to guide choice between them. This study aims to explore the use of Remimazolam compared to propofol in patients undergoing colonoscopy....
Open Access DOI:10.23937/2378-3656/1410454
Sew What? Navigating the Intricacies of a Needle in the Eye
Daniel Magee, David Jamison, Hoà Đỗ, Hong Van Ngo, Lam Vinh Tran, Song Tuan Vu, Tay Van Tran, Tam Minh Nguyen, Huy Ngoc Tran, Truong Minh Le, Phuc Hoang Nguyen, Nhut Hong Vo, Bich Anh Tran, Khiem Thien Tran and Thiện Hoàng
Article Type: Case Report | First Published: 2024/07/31
A female in her 20s presents to the emergency eye clinic with a painful, red right eye (OD) with visual loss down to light perception following non-accidental penetrating trauma of an iron sewing needle two weeks prior to presentation. This is thought to be as a result of auditory hallucinations possibly from undiagnosed schizophrenia for a large proportion of her life. After extensive investigations, it was found that she had exogenous endophthalmitis from the foreign body which was treated wit...
Open Access DOI:10.23937/2378-3419/1410189
NMR Spectroscopy-Based Metabolomics Profiling: A Clinically Helpful Approach for Prostate Cancer Early Detection
Pradeep Kumar and Sujeet Kumar Mewar
Article Type: Review Article | First Published: 2024/08/03
PCa diagnosis is difficult since there is/are no acceptable, sensitive, and specific tumor biomarkers. The most common cancer in the world to be diagnosed in males over 50 is prostate cancer (PCa). In its early stages, there are no symptoms, and the cancer grows slowly. Measuring a predetermined list of certain metabolites is the goal of metabolomics. Understanding metabolites and their metabolic pathways is essential for finding new biomarkers, and the most significant pattern may have a big im...
Open Access DOI:10.23937/2474-3674/1510163
The Role of Neutrophils in ARDS and Drugs that Modify their Formyl Peptide Receptor Activity
Veronica A Varney, BSc hons, MBBS, FRCP, MD, Gopal Chattopadhyay, MBBS, MRCP, Vishnu Bharadwaj Sai, MBBS, Samina Monir, MBBS, Abhishek Ray, MBBS, Alex Nicholas, BSc, MSc, FIBMS, Brian Ford, BSc hons, MSc, PhD, Ginny Quirke, RN, Dip N, BSc (Hons), Amolak Bansal, BM, FRCP, FRCPath, DM and Syed Rehan Quadery, MBBS, FRCP, MD
Article Type: Original Article | First Published: 2024/08/02
Adult Respiratory Distress Syndrome (ARDS) represents a sustained neutrophil driven attack on the lung, where raised alveolar neutrophil numbers are known to predict severity and mortality. Neutrophil infiltration to the lung is in response to released Formyl Peptides from infected and damaged tissue which can drive oxidant and protease release with toxic effects. Formyl Peptides can stimulate neutrophils directly via their surface Formyl Peptide Receptors (FPR’S), escalating their activation ...
Open Access DOI:10.23937/2469-5807/1510155
Histopathological Findings of Colonoscopic Biopsies from Sudanese Patients
Saeed Bashir Saeed Mohamed, Sahar Abdallah Mohamed Eltayeb, Sahar Hassan Mohamed Osman, Fatima Elbadri Mohammad Nour, Hafsa Adel Hassan Bashier, Namarig Elamin Babiker Mohamed Ahmed, Samah Batran, Aisha Adam Mohmmed, Fathelrahman AE Saaid, Ahmed Amin Mohammed and Hussain Gadelkarim Ahmed
Article Type: Research Article | First Published: 2024/08/02
Colorectal cancer (CRC) is the third most common malignancy and the second major cause of cancer deaths worldwide. The main aim of this study was to assess the histopathological findings of colonoscopic samples collected from Sudanese patients....
Open Access DOI:10.23937/2378-3419/1410188
Glucose-6-Phosphate Dehydrogenase Levels and Oxidative Stress Markers among Cancer Patients in Jos, Nigeria
Eugene Bwade Samuel, Amos Dangana, Taofeeq Oduola, Yinka J Oyeniyi, Liviticus Mansura Mangpin, Vileng Felix Gagari, Mercy Ekene Mobi, Ezeama Juliet Chika, Adesuyi A. Omoare, Muhammad Sani Usman and Idris Nasir Abdullahi
Article Type: Research Article | First Published: 2024/07/31
Glucose-6-phosphate dehydrogenase (G6PD) is a sensitive cytosolic antioxidant enzyme that could be associated with carcinogenesis. Hence, its plasma levels are a good indicator to monitor cancer-induced cellular stress. This study aimed to determine the correlation between Glucose-6-phosphate dehydrogenase and oxidative stress markers among cancer patients in Jos, Nigeria....
Open Access DOI:10.23937/2643-461X/1710078
A Neglected Tropical Disease in a Lebanese Patient: Chromoblastomycosis
Joe Khodeir, Paul Ohanian and Hala Abi Rached Megarbane
Article Type: Case Report | First Published: 2024/07/31
Histopathology showed hyperkeratotic skin with pseudoepitheliomatous epidermis and marked mixed interstitial inflammation suggestive of an infectious process. However, initial tests were inconclusive until characteristic spherical spores, indicative of muriform bodies, were identified through potassium hydroxide examination. Treatment with terbinafine was ineffective, but a multidrug regimen including cryotherapy, topical 5-Fluorouracil, and oral itraconazole resulted in significant lesion regre...
Open Access DOI:10.23937/2572-3286/1510098
Vitamin B12 Deficiency in Dialysis Patients: Risk Factors, Diagnosis, Complications, and Treatment - A Comprehensive Review
Ghada Araji, Praneeth Keesari, Varun Chowdhry, Jonathan Valsechi-Diaz, Sarah Afif, Wassim Diab and Suzanne El-Sayegh
Article Type: Review Article | First Published: 2024/07/27
Vitamin B12 deficiency is a significant concern among patients with end-stage kidney disease (ESKD) undergoing dialysis. However, there hasn't been extensive research conducted on this particular patient group. The reported incidence rates vary widely, ranging from 20% to 90%, reflecting the complexity of its diagnosis. Dialysis patients often face multiple nutritional deficiencies, including a lack of essential vitamins, due to factors such as dietary restrictions, impaired absorption, and nutr...