Open Access DOI:10.23937/2469-5807/1510115
Antiplasmodial Efficacy of Vernonia amygdalina in Albino Mice Infected with Plasmodium berghei
Olajide Joseph Afolabi and Jimoh Lateefat Oyewole
Article Type: Original Research | First Published: October 22, 2020
Malaria is one of the world's most serious diseases caused by Plasmodium parasite. It remains the greatest cause of hospitalization and death among human parasitic infections. Over 40% of the world’s population is at risk of malaria and active clinical cases due to Plasmodium falciparium. The study entitled “Antiplasmodial efficacy of Vernonia amygdalina in mice infected with Plasmodium berghei” is aimed at investigating the antiplasmodial activity of the ethanolic leaf exytract of Vernoni...
Open Access DOI:10.23937/2469-5807/1510114
Ovarian Cystic Lymphangioma: A Rare Case Report with Review of Literature
Swetha Narla, MD, Arshee Badar, DNB and Ann Kurian, MD
Article Type: Case Report | First Published: October 19, 2020
Lymphangiomas of the ovary are unusual benign tumours characterised by proliferation of lymphatic channels, composed of cystic spaces lined by a single layer of endothelial cells. We present a case of 61-year-old woman who presented with complaints of pain abdomen. Investigations revealed a large left ovarian multiseptate multiloculated cystic mass extending to pelvis, abdominal cavity and infraumbilical region likely neoplastic. Total abdominal hysterectomy with bilateral salpingo-oophorectomy ...
Open Access DOI:10.23937/2469-5734/1510120
Multiple Idiopathic External Apical Root Resorption: A Case Report
Mohanad Alsaedi, M Takriti and Ch Splieth
Article Type: Case Report | First Published: October 23, 2020
Idiopathic root resorption of the permanent dentition is a very rare condition which can be diagnosed during routine dental examinations. A 13-year-old German female was referred to the Unit of Pediatric Dentistry regarding fistulas of all her 1st permanent molars as the patient did not have any specific symptoms with regard to her teeth. All the first molars have been affected in a symmetrical pattern due to a massive idiopathic external root resorption. Clinically, the oral hygiene was very go...
Open Access DOI:10.23937/2469-5734/1510118
Determinants of Dental Caries among Preschool Children in Dessie Town, 2019: A Case-Control Study
Moges Workneh Ayele and Muluken Amare
Article Type: Research Article | First Published: October 12, 2020
The burden of childhood caries in developing countries is continued to be a significant problem and negatively affects the growth of the child. Despite, dental caries is substantially distressing children, there was the paucity of study on associated factors of dental caries in pre-school children in the study situate. A total of 130 cases and 260 controls were integrated into the study. A systematic random sampling technique was used to select schools. Structured questionnaires were used to col...
Open Access DOI:10.23937/2643-4059/1710022
A Scoping Review of the Association between Smartphone Use and Mental Health among College Students
Jeff Cain, EdD, MS, Jordan L Kelley, PharmD, BCPS and Daniel Malcom, PharmD
Article Type: Case Series | First Published: October 07, 2020
A scoping review of the literature reporting on smartphone use and parameters of mental health from January 2008 to February 2018 was performed for the purpose of summarizing and describing current research findings regarding the association of smartphone use with anxiety, depression, stress, and sleep of college students. The study followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols 2015 (PRISMA-P 2015) guidelines. Thirty-one articles met protocol crite...
Open Access DOI:10.23937/2378-2951/1410203
Unexpected Coronary Angiographic Findings in a Patient with Wellens’ Sign
Morris M Kim, MD, Jonathan S Taylor, MD, Jenna S Anderson, MD and Ignatius G Zarraga, MD
Article Type: Case Report | First Published: October 23, 2020
The abnormal electrocardiogram findings of Wellens’ sign that occur in the context of unstable angina are typically associated with significant stenosis in the proximal left anterior descending (LAD) coronary artery. We report an unusual case of a patient who had unstable angina and Wellens’ sign, without significant LAD stenosis. An 81-year-old man with moderate to severe aortic stenosis, hypertension, mild left ventricular hypertrophy, hyperlipidemia, and history of tobacco use presented t...
Open Access DOI:10.23937/2469-5831/1510030
Two-stage Adaptive Biomarker-Targeted Clinical Trial Design: Non-Parametric Bayesian and MLE Approaches
Huiding Chen, Ao Yuan and Ming T Tan
Article Type: Research Article | First Published: October 14, 2020
Biomarker targeted two-stage adaptive design is used increasingly in early-stage clinical trials in a variety of therapeutic areas including oncology, where the sample size of the trial is re-estimated based on the first stage data. In such trials often the sample size is moderate, and so incorporating prior information and using robust methods are desirable. In this article, to improve upon existing methods using parametric normal models, we propose a nonparametric Bayesian approach for designi...
Open Access DOI:10.23937/2690-3172/1710009
Cognitive Behaviour Assessment in Chronic Non Specific Low Back Pain: A Narrative Review
Seema Saini, Paresh Golwala, M.S., Lata Parmar, PhD, Devashish Tiwari, PhD, and Tushar J Palekar, PhD
Article Type: Research Article | First Published: October 15, 2020
Literature showed that patients with Chronic Low Back Pain (CLBP) have slowed speeds of information processing and working memory. Methods for assessment of cognition behaviour are decisive for the implementation Of Cognitive behavioural therapies. There remains a large component of the adherence process not assessed, while treating non specific chronic Low back Pain, and the known role for treatment appraisals and beliefs necessitating the pursuit of improved assessment methods. The purpose of ...
Open Access DOI:10.23937/2469-5696/1410058
Coping with Bleeding Disorders
Tony Brown
Article Type: Case Report | First Published: October 14, 2020
Living with a bleeding disorder is something that very few live within the United States. In fact, hemophilia occurs in only approximately 1 in 5,000 live births. There are about 20,000 people with hemophilia A in the US. Hemophilia B is four times less common than hemophilia A. von Willebrand Disease is much more common than both hemophilia A & B which is believed to effect 1% of the population. Von Willebrand disease is estimated to affect 1 in 100 to 10,000 individuals. The 3 common bleeding ...