Open Access DOI:10.23937/2378-3397/1410123
Breast Fibromatosis Case Series and Literature Review
Thuraya Al Yazidi, Suad Al Aghbari, Badryia Al Qassabi and Marwa Al Riyami
Article Type: Case Report | First Published: January 30, 2021
Fibromatosis or desmoid tumor is a benign tumor that rarely affects the breast. It represents 0.2% of all breast tumors and 4% of all extra-abdominal desmoid tumors. Wide local excision with adequate safety margins is considered the standard of care. We report three cases of breast fibromatosis who were presented to and operated in the sultan Qaboos University. All of these cases underwent wide local excision. After close regular follow up now for six months no local recurrence was reported. Fib...
Open Access DOI:10.23937/2378-3397/1410122
Unusual Sites of Metastasis of Well-Differentiated Thyroid Cancer: A Systematic Review
Awadh Alqahtani
Article Type: Systematic Review | First Published: January 30, 2021
Thyroid cancer is one of the most common endocrine malignancies secondary to ovarian cancer. Its incidence has surged swiftly than that of any other malignancy in recent years. Well-differentiated thyroid cancers (WDTC) are relatively common and usually slow-growing tumors with a good prognosis, including three types: Papillary, follicular, and Hürthle cell carcinoma. The first metastatic sites of these types of cancer typically involve lymph nodes, lungs, brain, and bones. The PICOT included a...
Open Access DOI:10.23937/2469-5734/1510126
Two Case Reports of C-Shaped Mandibular Premolars with Three and Four Root Canals
Mohammed Sarhan Alzahrani
Article Type: Case Report | First Published: February 11, 2021
Commonly, the mandibular premolars’ root canal system is complex and usually requires special management skills in root canal treatment. The occurrence of three root canals in the mandibular first premolar is relatively uncommon. Furthermore, the four root canals in the second premolar are extremely rare and clinically quite challenging to manage. Proper knowledge of the root canal anatomy and delicate radiographic interpretation and clinical inspection is essential for successful root canal t...
Open Access DOI:10.23937/2469-5734/1510125
Influence of Access Cavity Design on Fatigue Resistance of Reciproc Blue: Conservative vs. Truss Access
Giacomo Corsentino
Article Type: Research Article | First Published: February 10, 2021
Several factors including the access to the root canal systems could influence the fatigue of rotating or reciprocating endodontic instruments. The aim of this study was to assess the effect of conservative (CAC) and truss access cavity (TAC) preparation on the cyclic fatigue resistance of endodontic nickel-titanium (NiTi) files. A total of sixty extracted human intact mandibular molars were selected and assigned to CAC or TAC group (n = 30). All samples received root canal treatment. A total of...
Open Access DOI:10.23937/2469-5734/1510124
The Importance of Reducing the Viral Load in the Oral Cavity
Michelle Moron Araújo
Article Type: Short Report | First Published: February 06, 2021
Coronavirus infection has been considered by the WHO (World Health Organization) as a global pandemic. Since its origin, it has posed a threat to global health, not so much because of its symptoms, but because of its rapid spread, contagion and the respiratory complications that it produces in patients with other chronic underlying conditions. The oral cavity has a high viral load, which is very important for oral hygiene and all biosafety protocols. In this year 2020, the world population has b...
Open Access DOI:10.23937/2378-3001/1410107
Peripheral Neuropathies after Bariatric Surgery: A Current Review
Aluísio Stoll, MD, MsC, Dedi Ferreira Alves Neto, Évelin Pereira da Silva, Kéli Daiane Papes, Maria Carolina MianoSelbach, Matheus Fellipe Nascimento de Souza, Letícia Caroline Breis, Laura Fiuza Parolim, MD, Pedro José Tomaselli, MD, MsC, PhD4 and Marcus Vinícius Magno Gonçalves, MD, PhD
Article Type: Non-Systematic Review | First Published: February 06, 2021
Bariatric surgery (BS) is an effective method for sustained weight loss and better quality of life. However, it has its complications. Among those, peripheral neuropathies are important, although underdiagnosed, complications after the surgery. The objective of this article is to describe the most prevalent peripheral neuropathies that may happen after BS, especially focusing on small fiber neuropathies, and the main nutritional deficits involved in these neuropathies. Further studies are needed...
Open Access DOI:10.23937/2643-4539/1710018
Alzheimer’s Disease: Beyond A Genetic Disease
Mostafa Showraki, MD, FRCPC
Article Type: Research Article | First Published: January 16, 2021
Alzheimer’s disease (AD), the most common type of dementia or neurodegenerative diseases since the beginning of the past century when it was coined by the German psychiatrist, Alois Alzheimer in 1901 holds an allusive etiology, and as a result failed most treatment and prevention strategies. Despite the common belief among the experts of AD being a genetic disease, the genetic heritability of this disease has such a wide range of 50-80% in twin and family studies that questions the totality of...
Open Access DOI:10.23937/2378-3419/1410144
CXCR4 Antagonist AMD3100 (Plerixafor) Modulates Immune Responses in the Tumor Microenvironment
Ziyao Liu, Jingzhe Wang and Huabiao Chen
Article Type: Mini Review | First Published: January 30, 2021
AMD3100 (Plerixafor), a specific antagonist of CXCR4, is the most potent small molecule non-peptide inhibitor to CXCR4/CXCL12 axis. The chemokine receptor CXCR4 and its ligand CXCL12 (SDF-1) expressed in a variety of tumor cells play an important role in regulating tumor biological behavior. The tumor microenvironment (TME) is the environment around a tumor, comprising blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix which are involved in tumor growth, i...