Open Access DOI:10.23937/2469-5718/1510191
A Neural Mobilization Treatment Strategy for Patients with Neurogenic Claudication Related to Degenerative Lumbar Spinal Stenosis: A Prospective Case Series
Reid Gehring, PT, ScD, Joan Potter-Brunet, PT, DPT, Phillip Sizer, PT, PhD, Kerry Gilbert, PT, ScD and Jean-Michel Brismée, PT, ScD
Article Type: Research Article | First Published: May 03, 2021
mobilization treatment strategy in patients with Neurogenic Claudication (NC) related to degenerative Lumbar Spinal Stenosis (LSS). Prospective case series. Seven older adults with NC related to LSS received a standardized treatment program. Outcome measures included the Swiss Spinal Stenosis questionnaire (SSS), Numeric Pain Rating Scale (NPRS), time to First Symptoms (TFS) and Total Ambulation Time (TAT). Outcomes were assessed at the 7th visit and 3-months. Improvements were noted at the 7th...
Open Access DOI:10.23937/2378-3516/1410155
Mycophenolate Adverse Effect Masquerading as Extensive Pneumatosis Intestinalis (PI) after Lung Transplantation
Fahid Alghanim, MD, Janaki Deepak, MBBS, Aldo Iacono, MD and Irina Timofte, MD
Article Type: Case Report | First Published: May 13, 2021
Pneumatosis Intestinalis (PI) is a rare post lung transplant complication which is characterized by the presence of gas within the wall of the small and large intestine. PI in lung transplant recipients has been previously described and is associated with disease of varying clinical trajectories. Here we describe a case of PI in a lung transplant recipient that was attributed to immunosuppression with Mycophenolate Mofetil (MMF) as evidenced by the presence of increased crypt epithelial apoptosi...
Open Access DOI:10.23937/2378-3516/1410154
The Mysterious Case of Missing Food from the Fridge: Sleep Eating on a Combination of Melatonin and Eszopiclone
Leilani Hernandez, MPH and Himanshu Agrawal, MD
Article Type: Case Report | First Published: May 13, 2021
Here we present a case of SRED induced by addition of melatonin to eszopiclone. For this patient, melatonin time release 3 mg was added to eszopiclone 3 mg at night for treatment of insomnia. He reported taking the melatonin for two nights and both mornings he found evidence that he had been up at night eating with no memory of it. He stopped the melatonin after these two nights and his sleep eating immediately resolved. Notably, he continued taking the eszopiclone after melatonin discontinuatio...
Open Access DOI:10.23937/2378-3516/1410153
Has COVID-19 Changed Medical Publications?
Macedo A, MD, PhD and Febra C, MD
Article Type: Letter to Editor | First Published: May 13, 2021
The COVID-19 pandemics took over our every-day lives with overwhelming consequences. Being this particularly manifested at people’s ordinary activities and social fields ranging from world politics to stock markets, arts, education or sport, it is also true with respect to scientific publications in the area of medicine. The number of medical publications in indexed journals has been increasing year after year, reaching, in 2019, the number of 1,268,272 indexed papers in PubMed. In the first h...
Open Access DOI:10.23937/2378-3001/1410110
Influence of BDNF Genotype on the Effect of Neuromodulation on Pain Signalling and Pain Perception in Humans
Magnus Thordstein, Walker S. Jackson, Mats Svantesson and Hedayat Rahin
Article Type: Case Series | First Published: May 10, 2021
Trans-spinal Direct Current Stimulation (tsDCS) can alleviate pain perception in humans through plastic processes. Brain Derived Neurotrophic Factor (BDNF) has been shown to influence a large number of physiological processes including those underpinning neural plasticity. A common polymorphism of BDNF (val66met), reduces the efficiency of plastic processes. We studied the effect of this BDNF polymorphism on the signalling and perception of thermal pain and to what degree these can be influenced...
Open Access DOI:10.23937/2643-4539/1710019
Clinical and Pre-Clinical Evidence for Enteric α-Synuclein Involvement in Parkinson’s Disease
Eliyahu M Kochman, BS, Kainat Akhtar, BS, Ali Alelayawi, BS and Damian S Shin, MS, PhD
Article Type: Research Article | First Published: May 08, 2021
Parkinson’s disease (PD) is the second most common neurodegenerative disease, presenting with the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and motor symptoms. Categorized as a synucleinopathy, the pathological hallmark of PD is intracellular filamentous Lewy bodies (LB), which are formed from protopathic aggregates. The most prevalent of these proteins is the presynaptic protein ɑ-synuclein (α-syn). While commonly attributed to neuronal death in SNpc, postmor...
Open Access DOI:10.23937/2643-3885/1710054
Postoperative Management of K-Wires in Percutaneous Foot Surgery
Arzac Ulla Ignacio
Article Type: Prospective, Descriptive Study | First Published: May 10, 2021
When a Kirschner wire (K-wire) is used percutaneously, the protruding end often causes discomfort and is associated with an increased risk of complications, such as pin loosening, infection, injury, etc. This study was undertaken to determine the ideal postoperative management when using these implants. We describe a surgical alternative for K-wire management in foot surgery. A prospective, descriptive study was conducted. A total of 39 patients (70 procedures) were enrolled in the study and und...
Open Access DOI:10.23937/2377-3634/1410140
Hospital-Acquired Diabetic Ketoacidosis (HADKA) - An Analysis Comparing Two Major Australian Hospitals
Ushank Ranasinghe and Shamasunder Acharya
Article Type: Original Research | First Published: May 10, 2021
We conducted a retrospective study looking at patients over 18 yrs who developed hospital- acquired Diabetic Ketoacidosis (HADKA) in two major hospitals in Hunter New England Health, NSW Australia between 1st July 2014 and 30th June 2018. The data were obtained from patient electronic medical records. The HADKA criteria were pH ≤ 7.3, bicarbonate ≤ 18 mmol/L, and positive ketones (urine or plasma). A subset of patients was defined as ‘inferred HADKA’ when there was no documented ketone l...