Open Access DOI:10.23937/2378-3664.1410035
Recent Trends in Nanoparticles Based Drug Delivery for Tuberculosis Treatment
Chandni Pachouri, Bharat Patel, Sandhya Shroti, Sandeep Shukla and Archna Pandey
Article Type: Review Article | First Published: November 26, 2021
Current treatment therapeutic approach for tuberculosis is the administration of first line drugs in the form of tablets and capsules for 4-6 months however; this approach leads to sever adverse effect. Therefore, present study was designed to achieving local and sustained targeting of ant tuberculosis drugs in order to reduce dose n frequency. Nanoparticles (NPs) have been found to be potential targeted and controlled release drug delivery systems. Various drugs can be loaded in the NPs to achi...
Open Access DOI:10.23937/2474-3674/1510129
Post-Intensive Care Syndrome in Newborns from a Nutritional and Neuromotor Perspective
Júnea Regina Pires Drews, Janaina Aparecida Campos, Polianna de Brito Guimarães, Romilda Maria Vidigal Trandafilov and Natascha Savernini
Article Type: Original Research | First Published: November 20, 2021
Premature newborns who need prolonged hospital stays may develop Post-Intensive Care Syndrome, which, as the term itself suggests, is characterized by post-hospital changes that manifest themselves in the physical, cognitive and/or nutritional fields. The advance of care in recent decades has provided greater survival for the newborns, thus allowing initial studies to characterize signs and symptoms which may indicate, in the future, the risk of developing PICS. Given the above, the aim of this ...
Open Access DOI:10.23937/2643-4512/1710069
Prevalence and Determinants of Visual Impairment among School Children in Qatar
Al Ashwal Shadi M, MSc, PhD
Article Type: Original Article | First Published: November 26, 2021
To evaluate the prevalence of visual impairment among school children in Qatar, through a screening protocol based on the WHO guidelines. Children of grades 1, 3, 5, 7 and 9 underwent screening for low vision during the academic year 2019-2020. Visual acuity measurement was performed by well-trained screeners using a Snellen chart at 6 meters with E symbol in which the 6/6 line was the standard for normal vision. Based upon the results of the visual acuity, data of each individual was entered in...
Open Access DOI:10.23937/2643-3966/1710047
Clinical Characteristics and Clinical Outcomes of Patients with Heart Failure Who Receive Public Assistance in Japan
Shingo Watanabe, MD
Article Type: Original Article | First Published: November 25, 2021
The number of patients with heart failure (HF) is increasing, which is a socio-economic problem. Past overseas studies have reported that low-income patients with HF do not receive adequate treatment for financial reasons and have poor clinical outcomes. In Japan, medical expenses are free if they receive public assistance called Seikatsu hogo (PA), and there is no disadvantage to low-income patients regarding medical expenses. The purpose of this study is to investigate the clinical characteris...
Open Access DOI:10.23937/2378-3656/1410372
Factitious Disorder: A Paradox Case with Recurrent Symptomatic Hypoglycemia
Dana Hassneiah, MD, Seyma Sevinc, MD, Kendyl Stewart, MD, Charlotte Chaiklin, MD and Marcia Williams, MD, FACP
Article Type: Case Report | First Published: November 28, 2021
The patient was hospitalized and started on a Dextrose intravenous infusion. She underwent primary adrenal insufficiency testing with a normal co-syntropin stimulation test. She had normal glucose levels throughout her hospitalization. She was discharged home with instruction to discontinue use of oral hypoglycemic medications. A week after discharge the patient was found unresponsive and was brought to the emergency department for further evaluation. En route to the hospital, the patient was no...
Open Access DOI:10.23937/2378-3656/1410371
Painless Cervical Lymphadenopathy in an Elderly Patient - A Rare Case of Rosai-Dorfman Disease and Hodgkin’s Lymphoma
Shi Ying Tan, MB, BCh, BAO, Pemasiri Upali Telisinghe, MBBS and Justin Fook Siong Keasberry, MB ChB, FRACP
Article Type: Case Report | First Published: November 22, 2021
Rosai-Dorfman disease is a rare, benign disease presenting with extensive lymphadenopathy. In this case, an 81-yearold gentleman with previous pulmonary tuberculosis, presented with painless cervical lymphadenopathy associated with generalized weakness, loss of appetite, and cough. The causes of cervical lymphadenopathy in elderly are comprehensive; hence thorough history taking, examination, and appropriate investigations are vital in diagnosing diseases. If blood investigations and imaging are...
Open Access DOI:10.23937/2474-3682/1510192
Candida Albicans Brain Microabscesses in a Preterm Neonate
António Bento Guerra, M Inês Nunes Marques, Sónia Antunes and Ana Serrano
Article Type: Clinical Image | First Published: November 20, 2021
We report the case of a male preterm at 27 weeks of gestational age, born by emergency cesarean section with 1195 g, of an untreated HIV-infected mother, with an unsupervised pregnancy. After immediate resuscitation, he was admitted to the neonatal intensive care unit (NICU). He was started on standard neonatal antiretroviral HIV prophylaxis and completed seven days of ampicillin and gentamicin. Due to Staphylococcus epidermidis late sepsis, he completed 21 days of cefotaxime and vancomycin, but...
Open Access DOI:10.23937/2474-3682/1510191
Intraoperative Fluoroscopy for Central Venous Catheter Tip Position- “Use It When U Have It Modality”
Nishant Patel, Abhishek Singh, Saranlal AM and Naveen Bokinala
Article Type: Clinical Image | First Published: November 20, 2021
Central venous catheters (CVC) are a vital part of an anaesthetist’s armamentarium for resuscitation during intraoperative emergencies and they carry an inherent risk associated with tip malposition. Various sources recommend catheter tip position at the distant one-third of superior venecava (SVC) as ideal. Our principle concern is to place the tip above the pericardial reflection of SVC to avoid vascular erosion and consequent pericardial tamponade. There are multiple ways of ensuring that t...
Open Access DOI:10.23937/2378-3656/1410370
Delayed Splenic Abscess Post Splenic Arterial Embolization for Trauma in a Patient with Previous Sleeve Gastrectomy
Thomas Vu, Charles Pilgrim, Warren Clements and Ee Jun Ban
Article Type: Case Report | First Published: November 20, 2021
In haemodynamically stable patients with blunt splenic injuries, non-operative management (NOM) including the use of selective splenic artery embolization have been shown to be an effective treatment option. Proximal splenic arterial embolization reduces bleeding by decreasing pulse pressure to the spleen, hence lowering intra-splenic arterial blood pressure and promoting thrombosis of injures vessels. Splenic tissue perfusion is still achieved through a collateral arterial network, deriving fro...