Open Access DOI:10.23937/2643-4539/1710023

Dual‐Specificity Tyrosine Phosphorylation‐Regulated Kinase‐1A (DYRK1A), A Master Regulatory Protein Involved in Down Syndrome Brain Alterations and Mental Disability, A Key Contributor to Neurodegenerative Disorders of Alzheimer's Disease and A Potential Therapeutic Target

Mohammed Rachidi

Article Type: Research Article | First Published: July 04, 2022

Down syndrome (DS) is the most frequent genetic disease characterized by several neuropathological features including alteration in neurogenesis, mental disability, cognitive impairments, learning-memory deficits and early onset of Alzheimer’s disease (AD). Over expression of chromosome 21 genes, localized in Down Syndrome Critical Region (DSCR), is the main cause of DS neuropathological features. We studied herein one of DSCR genes, DYRK1A (Dual-Specificity Tyrosine-Phosphorylation-Regulated ...

 Open Access DOI:10.23937/2469-5866/1410043

Spreading of Trigeminal Neuralgia and Hemifacial Spasm to Blepharospasm: What the Role for Neurovascular Compression of the Vth Cranial Nerve?

Sergio Altomare, Maria Stella Aniello, Ruggiero Leone and Maurizio Giorelli

Article Type: Case Report | First Published: June 30, 2022

Blepharospasm (BB) in an involuntary movement disorder characterized by stereotyped, bilateral, and synchronous spasms of the orbicularis oculi (OO) muscles. Spasms may be either brief or sustained and give rise either to narrowing or spasmodic closure of eyelids thus leading to functional blindness....

 Open Access DOI:10.23937/2572-4193.1510124

A Rare Incidental Encounter of a Foreign Body in the Nasopharynx during Endoscopic Assisted Adenoidectomy

Mahdy Mohammed Nassar

Article Type: Case Report | First Published: July 07, 2022

Otolaryngologists frequently encounter nasal foreign bodies, particularly among children and mentally retarded patients. Upper aerodigestive tract may harbour foreign bodies such as sponges, grains, toy parts, paper and cotton. Majority of inhaled foreign bodies may pass unnoticed and others can be a source of serious morbidity with occasional mortality if not identified on time and properly treated....

 Open Access DOI:10.23937/2572-4193.1510123

How I Do It: Compressive Neck Dressing in Immediate Post- Laryngectomy Period To Reduce Pharyngocutaneous Fistula Rate

Tam Ramsey, MD, Katherine L. Webb, BS, Vilok Desai, BS, Gillian Ridler, BS, Shivaali Maddali, BS, Neil Gildener Leapman, MD and Lisa Galati, MD

Article Type: Original Article | First Published: June 30, 2022

Pharyngocutaneous fistula (PCF) is the most common complication of total laryngectomy. Our objective is to present our compressive neck dressing protocol and demonstrate its effectiveness in reducing the rate of pharyngocutaneous fistula (PCF) development in patients after primary total laryngectomy (TL) and salvage TL....

 Open Access DOI:10.23937/2572-3243.1510114

Effects of Electronic Usage on the Musculoskeletal System in Adolescents and Young Adults: A Systematic Review

Jamie L Young, OTS, Madeline G Snell, OTS, Oscar Robles, OTS, Joan E Kelso, OTS, Alexia M Kammitsis, OTS, Nicole K Cloutier, OTS, Claudia Hilton, PhD, MBA, OTR, FAOTA and Karthik Mani, OTD, OTR, FACOT

Article Type: Systematic Review | First Published: June 30, 2022

Rapid developments in technology demand the use of various electronic devices in daily life. Adolescents and younger adults are reported to consume more technology compared to other age groups. Examining the health implications of device use may assist with population level prevention and wellness strategies and stakeholder education....

 Open Access DOI:10.23937/2572-3243.1510113

Knowledge, Attitude and Perception of Disability among Healthcare Workers in a Nigerian Tertiary Health Institution

Ebere Yvonne Ihegihu, Ben-Cletus Tochukwu Obieze, Chima Collins Ihegihu, Kenneth Umezulike Ani, Benjamin Uzodinma Chukwuka, Ngozi Iheukwumere and Uzoamaka Nnwakaego Akobundu

Article Type: Original Research | First Published: June 20, 2022

In Nigeria, people living with disabilities often face unintentional poor treatment and neglect. This cross-sectional study was aimed at exploring the level of knowledge, attitude, and perception of healthcare professionals towards PLWD in Nnamdi Azikiwe Teaching Hospital, Nnewi Anambra State....

 Open Access DOI:10.23937/2469-5718/1510228

Most Common Injuries in CrossFit Training: A Systematic Review

Channah Joelle Brandsema, Mirwais Mehrab and Nina Maria Cornelia Mathijssen

Article Type: Systematic Review | First Published: July 14, 2022

The injury rate for CrossFit training is relatively low in comparison to other fitness-related sports. Systematic reviews regarding the extent of number of injuries per body part and injury-related exercises in CrossFit training are scarce. The purpose of this study was to determine the injury prevalence and incidence in CrossFit participants, in particular of injured body parts, and to examine injury related exercises in CrossFit....

 Open Access DOI:10.23937/2469-5718/1510227

The Role of Fitness Status and Sex on Metabolic Flexibility during a Bout of High-Intensity Interval Exercise and a High- Fat Meal Challenge

Alyssa A. Olenick, Regis C. Pearson, Nathan T. Jenkins

Article Type: Research Article | First Published: July 13, 2022

We explored whether High-Intensity Interval Exercise (HIIE) could provide a novel method to test metabolic flexibility during exercise. We also aimed to assess substrate oxidation during HIIE and in response to a high-fat meal to determine if these assessments of metabolic flexibility are influenced by fitness and sex....

 Open Access DOI:10.23937/2469-5718/1510226

Validation of an Allometric Model to Predict Cardiorespiratory Fitness in Young adults from 20-M Shuttle Run Test Performance

Roger Ramsbottom , Alan M Nevill and Sharon A Plowman

Article Type: Research Article | First Published: July 11, 2022

Being able to screen for changes in CRF cost effectively as well as identifying variables to provide accurate values for aerobic fitness has been identified by numerous studies. The purpose of the present study was to investigate whether published models were valid predictors of CRF in young adults using previously unpublished 20 m SRT (shuttle run test) data....

 Open Access DOI:10.23937/2469-5718/1510225

Unilateral Seventh Rib Posterior Stress Fracture in a High School Baseball Pitcher

Mani Singh, MD, Nicholas Tsitsilianos, MD and Katherine Yao, MD

Article Type: Case Report | First Published: June 29, 2022

Posterior rib stress fractures are rare injuries that may occur in the overhead athlete, most commonly at the first or second rib level in collegiate or professional players. The purpose of this article is to present the unique case of a lower thoracic posterior rib stress fracture in a high school pitcher, as well as to describe the clinical presentation, diagnosis, and management of this condition....