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 Research Article 


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Published Date
September 29, 2017

Vol. 3, Issue 3

Relationship between Serum 25-Hydroxyvitamin D Levels, Disease Activity and Anti-Cyclic Citrullinated Peptide Antibody Levels in Indian Rheumatoid Arthritis Patients

Shradha C Borukar, Arun R Chogle and Sudha S Deo

Corresponding author: Sudha S Deo, Principal Scientist, Sir H. N. Medical Research Society; Sir H. N. Reliance Foundation Hospital and Research Centre, Raja Ram Mohan Roy Road, PrarthanaSamaj, Girgaum, Mumbai 400004, Maharashtra, India

In our study, 42 RA patients were selected according to the ACR Criteria and 50 healthy participants were recruited for comparison, as controls. After a detailed medical history and anthropometric evaluation, all participants were subjected to CRP analysis and their disease activity scores (DAS28-CRP) were calculated using DAS calculator.

Citation: Borukar SC, Chogle AR, Deo SS (2017) Relationship between Serum 25-Hydroxyvitamin D Levels, Disease Activity and Anti-Cyclic Citrullinated Peptide Antibody Levels in Indian Rheumatoid Arthritis Patients. J Rheum Dis Treat 3:056. doi.org/10.23937/2469-5726/1510056



 Research Article 


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Published Date
September 29, 2017

Vol. 3, Issue 3

Clinical and Ultrasonic Characteristics of 100 New Crystal Proven Gouty Patients in a Rheumatology Clinic

Ole Slot

Corresponding author: Ole Slot, MD, Department of Rheumatology and Spinal Disorders, The Copenhagen Center for Arthritis Research, Rigshospitalet Glostrup, DK 2600 Glostrup, Denmark

A 30-years old study reported gout to be oligo- or polyarticular in 40% of cases presenting to a rheumatology clinic. The prevalence of gout has increased markedly since and presently gout has become the most prevalent inflammatory joint disease. Furthermore, specific Ultrasound (US) changes in gout have been described in recent years.

Citation: Slot O (2017) Clinical and Ultrasonic Characteristics of 100 New Crystal Proven Gouty Patients in a Rheumatology Clinic. J Rheum Dis Treat 3:055. doi.org/10.23937/2469-5726/1510055



 Review Article 


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Published Date
June 12, 2017

Vol. 3, Issue 2

Rheumatoid Arthritis of the Craniovertebral Junction: Surgical Strategies, Current Approach and Proposal of a New Therapeutic Algorithm

Luis Eduardo Carelli Teixeira da Silva, Alderico Girao Campos de Barros and Marcelo Glauber da Silva Pereira

Corresponding author: Luis Eduardo Carelli Teixeira da Silva, National Institute of Traumatology and Othopaedics, Rio de Janeiro, Brazil

Rheumatoid Arthritis (RA) is a systemic inflammatory disease with an autoimmune feature and an etiology that is still unknown. It is characterized by a symmetrical peripheral polyarthritis that affects primarily the small joints of hands and feet, with several levels of extra-articular manifestation.

Citation: da Silva LECT, de Barros AGC, Pereira MGS (2017) Rheumatoid Arthritis of the Craniovertebral Junction: Surgical Strategies, Current Approach and Proposal of a New Therapeutic Algorithm. J Rheum Dis Treat 3:052. doi.org/10.23937/2469-5726/1510052



 Case Report 


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Published Date
March 18, 2017

Vol. 3, Issue 2

A Pediatric Case of NMOSD with Positive Seroconversion of AQP4-ab after 5 Years and Subsequent Diagnosis of SLE

Aisha Bushra, Osman Farooq, Svetlana P Eckert, Caila B Vaughn, Rabheh Abdul Aziz and Bianca Weinstock-Guttman

Corresponding author: Bianca Weinstock-Guttman, MD, Professor, Department of Neurology, State University of New York at Buffalo; Director, Jacobs MS Center for Treatment and Research, USA, E-mail: bweinstock-guttman@kaleidahealth.org

Neuromyelitis optica spectrum disorder (NMOSD) is a demyelinating disorder of the central nervous system that is distinct from multiple sclerosis and is primarily characterized by recurrent episodes of optic neuritis (ON) and/or longitudinal extensive transverse myelitis (LETM). The presence of aquaporin antibodies (AQP4-ab) in the serum and/or cerebrospinal fluid (CSF) is a highly specific biomarker for diagnosis, although repeated testing may be necessary to confirm its presence.

Citation: Bushra A, Farooq O, Eckert SP, Vaughn CB, Aziz RA, et al. (2017) A Pediatric Case of NMOSD with Positive Seroconversion of AQP4-ab after 5 Years and Subsequent Diagnosis of SLE. J Rheum Dis Treat 3:051. 10.23937/2469-5726/1510051.



 Review Article 


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Published Date
March 01, 2017

Vol. 3, Issue 2

Role of Strontium Ranelate in the Therapy of Osteoporosis

Pavel Horak, Martina Skacelova and Ahmed Kazi

Corresponding author: Prof. Pavel Horak, MD, PhD, Faculty of Medicine and Dentistry, Department of Internal Medicine III, Nephrology, Rheumatology and Endocrinology, Palacky University of Olomouc, I.P.Pavlova 6, 772 00 Olomouc, Czech Republic

Strontium ranelate is a medicine used to treat postmenopausal osteoporosis in women and osteoporosis in men. Preclinical data suggest its dual effect consisting of the control of bone resorption and promotion of bone formation. Administration of strontium ranelate leads to significant increase in the bone mass. Changes in bone density can be used to evaluate the adherence of patients as well as, in case of strontium ranelate, to estimate the fracture risk reduction.

Citation: Horak P, Skacelova M, Kazi A (2017) Role of Strontium Ranelate in the Therapy of Osteoporosis. J Rheum Dis Treat 3:050. 10.23937/2469-5726/1510050



 Letter to the Editor 


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Published Date
February 21, 2017

Vol. 3, Issue 1

Rheumatic Disease Frequency in Hospitilized Acute Stroke Patients

Nihal Ozaras, M Serdar Sag, M Akif Sariyildiz and Sule Deveci

Corresponding author: Nihal Ozaras, Department of Physical Medicine and Rehabilitation, Bezmialem Vakif University of Istanbul, Turkey

Rheumatic diseases (RD) have increased risk for stroke. We examined the records of acute stroke patients for concomitant diseases. Two of 178 patients had gout, no other RD was detected. Considering the result of our study and current evidence in the literature, we suggest that patients with gout should be monitored closely for the risk of stroke and the clinician should be aware of higher risk of stroke in these patients.

Citation: Ozaras N, Sag MS, Sariyildiz MA, Deveci Ş (2017) Rheumatic Disease Frequency in Hospitilized Acute Stroke Patients. J Rheum Dis Treat 3:049.



 Review Article 


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Published Date
February 21, 2017

Vol. 3, Issue 1

SLE - Update Ethiopathogenesis Leading to Biological Therapy

J Rovensky, S Blazickova and I Stiborova

Corresponding author: Jozef Rovensky, National Institute of Rheumatic Diseases, Piestany, Slovak Republic

Systemic lupus erythematosus is a chronic, autoimmune disorder which may have even fatal consequences, particularly if it affects vital organs of the human body. It is typically manifested by inflammation of various organ systems. The course of the disease includes sporadic flare-ups, or relapses, which may lead to irreversible damage of the organs. The focus is on the suppression of clinical symptoms, inhibition of the formation of autoantibodies induce remission, preventing relapse and irreversible organ damage while maintaining the best possible quality of life for the patient.

Citation: Rovensky J, Blazickova S, Stiborova I (2017) SLE - Update Ethiopathogenesis Leading to Biological Therapy. J Rheum Dis Treat 3:048.



 Research Article 


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Published Date
February 21, 2017

Vol. 3, Issue 1

Glucocorticoid-Induced Leucine Zipper (Gilz) in Rheumatoid Arthritis: Relationship with Disease Activity and Steroid Use

Laura E Eades, Angeline S Thiagarajah, Sarah A Jones, Huapeng Fan, Anastasios Nalpantidis, Eric F Morand and Michelle Leech

Corresponding author: Laura Eades, Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Monash Medical Centre, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia

Clinical data was obtained from RA patients and medical records. Three control cohorts were also recruited, including 23 healthy controls, 25 patients with fibromyalgia and 44 patients with depression. Blood was taken from each participant. Following isolation of peripheral blood mononuclear cells (PBMC) from whole blood, RNA was extracted. Reverse transcription polymerase chain reaction (RT PCR) and quantitative real time PCR (qPCR) were performed to quantify GILZ expression.

Citation: Eades LE, Thiagarajah AS, Jones SA, Fan H, Nalpantidis A, et al. (2017) Glucocorticoid-Induced Leucine Zipper (Gilz) in Rheumatoid Arthritis: Relationship with Disease Activity and Steroid Use. J Rheum Dis Treat 3:047.



 Case Report 


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Published Date
February 14, 2017

Vol. 3, Issue 1

Scleroderma Renal Crisis

Gioacchino Li Cavoli, Luisa Bono, Calogera Tortorici, Carlo Giammarresi, Tancredi Vincenzo Li Cavoli and Ugo Rotolo

Corresponding author: Dr. Gioacchino Li Cavoli, Nephrology-Dialysis, Civico-Benfratelli and Di Cristina Hospital, 43 via Francesco Cilea, 90144 Palermo, Italy

Scleroderma or Systemic sclerosis is a vascular and fibrotic disease with organ-based complications and high mortality and morbidity. Renal involvement can be quite varied and scleroderma renal crisis is the most severe manifestation. We report our experience. In February 2016 a 52-year-old male was admitted to hospital with pulmonary oedema and severe arterial hypertension (240/120 mmHg).

Citation: Cavoli GL, Bono L, Tortorici C, Giammarresi C, Cavoli TVL, et al. (2017) Scleroderma Renal Crisis. J Rheum Dis Treat 3:046. 10.23937/2469-5726/1510046



 Research Article 


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Published Date
February 13, 2017

Vol. 3, Issue 1

Relapsing Polychondritis with Central Nervous System Involvement Presented as Encephalitis: 7 Cases and Literature Review

Anna Zhou, Xindi Li, Lin Zhao, Yonghong Liu and Xinghu Zhang

Corresponding author: Xinghu Zhang, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.6 Tiantanxili, Dongcheng District, Beijing, 100050, China

Objectives: This study aims to describe the clinical manifests, CSF features and brain MRI characters of patients with relapsing polychondritis (RP) and central nervous system (CNS) involvement presented as encephalitis. Methods: Seven cases with RP and CNS involvement were enrolled from 2011 to 2015. RP was diagnosed upon the modified McAdam criteria, and CNS dysfunction secondary to RP was decided by clinical manifests, CSF analysis and brain MRI.

Citation: Zhou A, Li X, Zhao L, Liu Y, Zhang X (2017) Relapsing Polychondritis with Central Nervous System Involvement Presented as Encephalitis: 7 Cases and Literature Review. J Rheum Dis Treat 3:045. 10.23937/2469-5726/1510045



 Research Article 


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Published Date
January 31, 2017

Vol. 3, Issue 1

Is There a Correlation Between DAS28/RADAI in a Cohort of Rheumatoid Arthritis Patients Treated with Biological Therapy

Hèctor Corominas, Silvia García-Diaz, Salvador Campos, Silvia Sánchez-Serrano, Silvia Iniesta, Isabel Padró, Lucinda Sanchez-Eslava, Elena Fernández-Casado, Montse Sesma, Cristina Saura, Mari Carmen Rodríguez, Maria Rusiñol and Montse Jordana

Corresponding author: Dr. Hèctor Corominas, Servei de Reumatologia, Hospital Moisès Broggi/Hospital General de l'Hospitalet, Consorci sanitari integral (CSI), Jacint Verdaguer 90, 08970. Sant Joan Despi, Barcelona, Catalonia

Rheumatoid arthritis (RA) is a chronic inflammatory heterogeneous disease presenting with acute flares, showing a prevalence of 0.5% in Spanish population according to the study EPISER and an annual incidence of 8.3 cases per 100,000 population, and that in the absence of optimal and individualized treatment causes a long-term severe disability.

Citation: Corominas H, Garcia-Diaz S, Campos S, Sanchez-Serrano S, Iniesta S, et al. (2017) Is There a Correlation Between DAS28/RADAI in a Cohort of Rheumatoid Arthritis Patients Treated with Biological Therapy. J Rheum Dis Treat 3:044.



 Review Article 


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Published Date
October 10, 2016

Vol. 2, Issue 4

Relapsing Polychondritis

Jozef Rovensky and Marie Sedlackova

Corresponding author: Jozef Rovensky, National Institute of Rheumatic Diseases, Piestany, Slovak Republic

Relapsing polychondritis (RP) is a rare immune-mediated disease that may affect multiple organs. It is characterised by recurrent episodes of inflammation of cartilaginous structures and other connective tissues, rich in glycosaminoglycan. Clinical symptoms concentrate in auricles, nose, larynx, upper airways, joints, heart, blood vessels, inner ear, cornea and sclera.

Citation: Rovensky J, Sedlackova M (2016) Relapsing Polychondritis. J Rheum Dis Treat 2:043.



 Case Report 


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Published Date
October 03, 2016

Vol. 2, Issue 4

TB: Falsely Accused? (A Case Report and Discussion)

Kelsy Greenwald and Jo Ann Ball

Corresponding author: Kelsy Greenwald, Rheumatology, Desert Medical Advances, 72855 Fred Waring Dr., Palm Desert, CA 92260, USA

Interferon-Gamma Release Assays (IGRAs) in the past decade have become ubiquitous screening for tuberculosis (TB). Development of these interferon release tests helped screen for TB in patients at high risk, specifically those with human immunodeficiency virus (HIV). The blood test was designed to strongly stimulate interferon release when blood was exposed to a tube laced with TB antigens.

Citation: Greenwald K, Ball JA (2016) TB: Falsely Accused? (A Case Report and Discussion). J Rheum Dis Treat 2:042.



 Research Article 


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Published Date
October 01, 2016

Vol. 2, Issue 4

Salivary Glands Ultrasonography in Rheumatoid Arthritis Patients. Its Role in Early Detection of Secondary Sjogren's Syndrome

Amal Mohamad El-Barbary, Marwa Ahmed Aboelhawa, Abeer Abdelmenem Shahba, Noha Mohamed Shafik, Hala Elsayed Hamouda and Hossam Abdelhafiz Zaytoun

Corresponding author: Amal Mohamad El-barbary, MD, Assistant Professor, Department of Rheumatology and Rehabilitation, Faculty of Medicine, Tanta University, Egypt

One hundred and fifty RA patients classified into two equal subgroups according to the presence of sicca symptoms, in addition to seventy five healthy controls. All patients were subjected to self-reported questionnaire about sicca symptoms, DAS 28, Unstimulated whole salivary flow rate (UWSFR), Schirmer's test, ESR, CRP, RF, Anti- CCP, Anti-Ro, Anti-La antibodies, serum and salivary CXC ligand 13 (CXCL13), B cell activating factor (BAFF), ultrasonography for major salivary gland and biopsy of minor salivary gland.

Citation: El-Barbary AM, Aboelhawa MA, Shahba AA, Shafik NM, Hamouda HE, et al. (2016) Salivary Glands Ultrasonography in Rheumatoid Arthritis Patients. Its Role in Early Detection of Secondary Sjogren's Syndrome. J Rheum Dis Treat 2:041.



 Research Article 


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Published Date
September 21, 2016

Vol. 2, Issue 3

MR Imaging of Degenerative Cartilage Lesions of the Knee Joint in Floor Layers and Graphic Designers

Soren Rytter, Birthe Lykke Thomsen, Birgitte Schutt Christensen and Lilli Kirkeskov

Corresponding author: Soren Rytter, MD, PhD, Assistant Professor, Department of Orthopedics, University Clinic for Hand, Hip and Knee Surgery, Regional Hospital West Jutland, Holstebro, Denmark

Kneeling work leads to an additional risk of developing knee osteoarthritis (OA). Previous studies have primarily been based on radiography, but radiography is limited by its inability to visualize articular cartilage, in which the earliest signs of OA occur. The objective of this explorative study, based on available data, was to examine the prevalence of magnetic resonance imaging (MRI)-detected knee cartilage lesions in male floor layers exposed to kneeling work, as compared to non-exposed male graphic designers.

Citation: Rytter S, Thomsen BL, Christensen BS, Kirkeskov L (2016) MR Imaging of Degenerative Cartilage Lesions of the Knee Joint in Floor Layers and Graphic Designers. J Rheum Dis Treat 2:040.



 Research Article 


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Published Date
September 17, 2016

Vol. 2, Issue 3

Implementation of Evidence-Based Practice in Rheumatology: What Sociodemographic, Social Cognitive and Contextual Factors Influence Health Professionals' Use of Research in Practice?

Neher M, Stahl C, Festin K and Nilsen P

Corresponding author: Margit Neher, Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden

Research on the use of research in rheumatology practice is largely lacking. This study attempts to fill this knowledge gap by exploring the degree to which evidence-based practice (EBP) is implemented in clinical rheumatology practice and identifying individual and organizational factors that may potentially affect research use in the clinical environment.

Citation: Neher M, Stahl C, Festin K, Nilsen P (2016) Implementation of Evidence-Based Practice in Rheumatology: What Sociodemographic, Social Cognitive and Contextual Factors Influence Health Professionals' Use of Research in Practice? J Rheum Dis Treat 2:039.



 Research Article 


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Published Date
September 02, 2016

Vol. 2, Issue 3

Impact of the Addition of Ginger Extract and Copper Sulphate to Glucosamine Sulphate on Il-1Beta-Stimulated Chondrocytes

Francis Rousset, Laurent Grange, Minh Vu Chuong Nguyen, Clara Pinosa-Zezza, Philippe Gaudin, Thierry Conrozier, Francoise Morel and Bernard Lardy

Corresponding author: Bernard Lardy, Biochemical Enzymology and protein laboratory, University hospital A. Michallon, Grenoble, France

This study provided experimental evidence that glucosamine sulfate decreases ADAMTS5 expression and apoptosis. In addition, ginger root and copper sulphate decreased pro-MMP1 expression by regulating NOX4 activity. Our data suggest the implication of Heme Oxygenase-1 in the molecular mechanisms.

Citation: Rousset F, Grange L, Nguyen MVU, Pinosa-Zezza C, Gaudin P, et al. (2016) Impact of the Addition of Ginger Extract and Copper Sulphate to Glucosamine Sulphate on Il-1β-Stimulated Chondrocytes. J Rheum Dis Treat 2:038.



 Case Report 


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Published Date
July 03, 2016

Vol. 2, Issue 3

Chronic Large Joint Synovitis in Systemic Lupus Erythematosus: Finding What You Look For

B Hodkinson, I Okpechi and SA Botha-Scheepers

Corresponding author: Dr. Bridget Hodkinson, Department of Medicine, Division of Rheumatology, University of Cape Town and Groote Schuur Hospital, Groote Schuur Hospital, Cape Town, South Africa

A 30-year-Black African female was diagnosed with SLE when she presented with a Coombs positive haemolytic anaemia, lymphopenia, polyarthritis, oral ulcers and a malar rash. Her antinuclear antigen (ANA) was positive, she had hypocomplementaemia and she was HIV negative. She was commenced on oral corticosteroids (initially high dose 60 mg/day and later weaned to 15 mg daily), chloroquine sulphate and azathioprine. Her blood counts and SLE symptoms improved. Four months after diagnosis, she developed a right knee monoarthritis.

Citation: Hodkinson B, Okpechi I, Botha-Scheepers SA (2016) Chronic Large Joint Synovitis in Systemic Lupus Erythematosus: Finding What You Look For. J Rheum Dis Treat 2:037.



 Case Report 


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Published Date
June 02, 2016

Vol. 2, Issue 2

Vogt-Koyanagi-Harada-Syndrome Concurrent with Morbus Darier

Claudia Eve Thieme, Sibylle Winterhalter, Bianca Apitzsch and Nicole Stuebiger

Corresponding author: Nicole Stuebiger, MD, Department of Ophthalmology, Charite, Campus, Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany

Vogt-Koyanagi-Harada-syndrome (VKH) is a multisystemic, T-cell mediated autoimmune disorder which is characterized by bilateral granulomatous panuveitis with extraocular manifestations in the central nervous and auditory system as well as in the integumentary field. Neurological and auditory manifestations include aseptic meningitis, meningism, tinnitus and cerebrospinal fluid pleocytosis. Integumentary findings can include alopecia, poliosis and vitiligo. The etiology of this disease is thought to be an immune reaction against melanocytes.

Citation: Thieme CE, Winterhalter S, Apitzsch B, Stuebiger N (2016) Vogt-Koyanagi-Harada-Syndrome Concurrent with Morbus Darier. J Rheum Dis Treat 2:036.



 Research Article 


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Published Date
May 10, 2016

Vol. 2, Issue 2

Association of Markers of Oxidative Stress, Medication Therapy and Life Habits in Fibromyalgia

Joao Eduardo Torrecillas Sartori, Luiz Fernando Cireia, Denise Poltronieri Martins, Gabriela do Prado Rocha, Juliany Roberta Cintra, Ana Luiza de Aquino Oliveira, Juliana Goncalves Yogolare, Lucas Romagnolli, Alexandre de Andrade Budin, Sabrina Mayara Cezario, Marcela Augusta de Souza Pinhel, Camila Ive Ferreira Oliveira, Doroteia Rossi da Silva Souza, Gerardo Maria de Araujo Filho and Lazslo Antonio Avila

Corresponding author: Denise Poltronieri Martins, Research Center for Biochemistry and Molecular Biology at the Medical School of Sao Jose do Rio Preto, Brazil

Objective: To evaluate the association among genetic polymorphisms of glutathione S-transferase, oxidative stress, lifestyle habits and medication therapy in patients with fibromyalgia (FM). Patients and methods: A total of 187 women (22-84 years) were studied: 81 patients with fibromyalgia (G1) and 106 individuals without the disease (G2). They had their peripheral blood sample submitted for analysis of GSTM1 and GSTT1 polymorphisms, serum levels of thiobarbituric acid reactive substances (TBARS) and trolox equivalent antioxidant capacity (TEAC). All subjects were asked to complete a questionnaire for data registry.

Citation: Sartori JET, Cireia LF, Martins DP, Rocha GP, Cintra JR, et al. (2016) Association of Markers of Oxidative Stress, Medication Therapy and Life Habits in Fibromyalgia. J Rheum Dis Treat 2:035.



 Research Article 


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Published Date
April 01, 2016

Vol. 2, Issue 2

HLA-DR Frequency in Individuals with Rheumatoid Arthritis and Lung Affection

Maria do Socorro Teixeira Moreira Almeida, Joao Vicente Moreira Almeida, Manoel Barros Bertolo, Catarina Fernandes Pires and Viriato Campelo

Corresponding author: Maria do Socorro Teixeira Moreira Almeida, Adjunct Professor of Rheumatology, Department of Medical Clinic, Federal University of Piaui, Universitary Hospital, Campus Ministro Petronio Portella, Teresina, Piaui, Brasil

Rheumatoid arthritis (RA) is an autoimmune disease whose etiology is unknown, while its immunopathogenesis involves the participation of both genetic and environmental factors. Human leukocyte antigen DR4 (HLA-DR4) exhibits a strong association with RA in various populations and ethnic groups; in addition, a heightened frequency of HLA-DR1 among individuals with RA has been found in some populations.

Citation: Almeida MSTM, Almeida JVM, Bertolo MB, Pires CF, Campelo V (2016) HLA-DR Frequency in Individuals with Rheumatoid Arthritis and Lung Affection. J Rheum Dis Treat 2:034.



 Research Article 


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Published Date
April 01, 2016

Vol. 2, Issue 2

Novel Application of Behavioral Assays Allows Dissociation of Joint Pathology from Systemic Extra-Articular Alterations Induced by Inflammatory Arthritis

Ann K Harvey, Mariah J Lelos, Claire J Greenhill, Ashley T Jones, Susanne P Clinch, Michael J Newton, Stephen B Dunnett, Sean L Wyatt, Anwen S Williams and Simon A Jones

Corresponding author: Prof. Simon A. Jones, Institute of Infection & Immunity, School of Medicine, Cardiff University, Heath Campus, Cardiff CF14 4XN, Wales, UK

Although rheumatoid arthritis (RA) is a disease of articular joints, patients often suffer from co-morbid neuropsychiatric changes, such as anxiety, that may reflect links between heightened systemic inflammation and abnormal regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Here, we apply behavioral neuroscience methods to assess the impact of antigen-induced arthritis (AIA) on behavioral performance in wild type (WT) and interleukin-10 deficient (Il10-/-) mice. Our aim was to identify limb-specific motor impairments, as well as neuropsychological responses to inflammatory arthritis.

Citation: Harvey AK, Lelos MJ, Greenhill CJ, Jones AT, Clinch SP, et al. (2016) Novel Application of Behavioral Assays Allows Dissociation of Joint Pathology from Systemic Extra- Articular Alterations Induced by Inflammatory Arthritis. J Rheum Dis Treat 2:033.



 Research Article 


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Published Date
March 31, 2016

Vol. 2, Issue 1

Meta-Analysis of the Clinical Efficacy of the Placebo Effect from Tumour-Necrosis-Factor Inhibitors to Treat Rheumatoid Arthritis after Methotrexate Failure

Julie Azais, Pascale Vergne-Salle, Christine Bonnet, Carine Dufauret-Lombard, Richard Treves and Philippe Bertin

Corresponding author: Trainee Julie Azais, Department of Rheumatology, University hospital of Limoges, CHU Dupuytren, Service de Rhumatologie - 2, avenue Martin Luther King, 87000 Limoges, France

Tumour-necrosis-factor (TNF) inhibitors, used to treat rheumatoid arthritis (RA), have non-specific (placebo effect) and specific effects. This meta-analysis appraises these effects within the first 3 months of treatment. Data were collected from ACR 20, 50 and 70 scores at week-24 from RA patients receiving TNF-blockers or a placebo after methotrexate (MTX) failure.

Citation: Azais J, Vergne-Salle P, Bonnet C, Dufauret-Lombard C, Treves R, et al. (2016) Meta-Analysis of the Clinical Efficacy of the Placebo Effect from Tumour-Necrosis-Factor Inhibitors to Treat Rheumatoid Arthritis after Methotrexate Failure. J Rheum Dis Treat 2:032.



 Case Report 


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Published Date
February 07, 2016

Vol. 2, Issue 1

Erdheim-Chester Disease: A Case of Cardiac and Hypophyseal Involvement Showing Positive Response with High Dose Pegylated Interferon-Α

Annie HN Law and SI Yeo

Corresponding author: Dr. Annie HN Law, Department of Rheumatology and Immunology, Academia Building Level 4, College Road, 169856, Singapore

Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis, with multifaceted clinical presentations. There are currently fewer than 550 cases reported in the literature. This case illustrates the protean manifestations of ECD with multisystem involvement, including skeletal and extra skeletal (cutaneous, cardiac, pituitary, retroperitoneal, and pulmonary) manifestations

Citation: Law AHN, Yeo SI (2016) Erdheim-Chester Disease: A Case of Cardiac and Hypophyseal Involvement Showing Positive Response with High Dose Pegylated Interferon-Α. J Rheum Dis Treat 2:031.



 Research Article 


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Published Date
January 26, 2016

Vol. 2, Issue 1

Biomechanical Stimulation Therapy - An Efficacious Method for Facial Scleroderma with Reduced Oral Aperture

Walter Berg, Ingo H Tarner, Gabriela Riemekasten, Ulf Muller-Ladner and Uwe Lange

Corresponding author: Dr. Uwe Lange, MD, Professorship of Rheumatology, Osteology and Physical Medicine, Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Germany

Systemic sclerosis (SSc) is a chronic, severe connective tissue disorder characterized by a microangiopathy and excess deposition of connective tissue matrix in the skin and internal organs. Skin involvement is the most conspicuous manifestation of SSc, and based on its extent two distinct disease subsets are recognized, diffuse cutaneous (dcSSc) and limited cutaneous systemic sclerosis (lcSSc), with lcSSc affecting only the distal extremities and the face and dcSSc also affecting the proximal extremities and the trunk.

Citation: Berg W, Tarner IH, Riemekasten G, Muller-Ladner U, Lange U (2016) Biomechanical Stimulation Therapy - An Efficacious Method for Facial Scleroderma with Reduced Oral Aperture. J Rheum Dis Treat 2:030.



 Case Series 


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Published Date
January 09, 2016

Vol. 2, Issue 1

Anti-inflammatory Effect of Antioxidant Pequi (Caryocar Brasiliense) Oil Capsules and Antioxidant Effect of Vitamin D and Physical Activity on Systemic Lupus Erythematosus Patients

Thais Muniz Montalvao, Ana Luisa Miranda-Vilela, Cesar Koppe Grisolia and Leopoldo Luiz Santos-Neto

Corresponding author: Ana Luisa Miranda-Vilela, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brazil

Systemic lupus erythematosus (SLE) is a chronic inflammatory, complex, multisystem autoimmune disease of multifactorial origin. It is characterized by a large set of antibodies, especially antinuclear antibodies. Its incidence rate varies from 1 to 10 per 100,000 persons/year and its prevalence rate is 20-70 per 100,000. It is a more frequent rare disease in women between 15 and 45 years old. The cause of SLE is still unknown; however, there is a loss of the regulatory mechanisms which maintain self-tolerance to nuclear antigens, resulting in the deposition of immune complexes in tissues.

Citation: Montalvao TM, Miranda-Vilela AL, Grisolia CK, Santos-Neto LL (2016) Anti-inflammatory Effect of Antioxidant Pequi (Caryocar Brasiliense) Oil Capsules and Antioxidant Effect of Vitamin D and Physical Activity on Systemic Lupus Erythematosus Patients. J Rheum Dis Treat 2:029.



 Case Series 


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Published Date
December 31, 2015

Vol. 1, Issue 4

Massive Serositis as the Initial Presentation of Systemic Lupus Erythematosus: A Report of Two Cases and Review of the Literature

Laura Geraldino-Pardilla Yevgeniya Gartshteyn and Fabian Mendoza

Corresponding author: Yevgeniya Gartshteyn, MD, Department of Medicine, Columbia University, College of Physicians & Surgeons, 177 Fort Washington Ave 8SK 8-004 New York, NY 10032, USA

Large volume effusions as a manifestation of active systemic lupus erythematous (SLE) is rare, and when it does occur, it is usually associated with complications of chronic lupus disease, such as nephrotic syndrome, constrictive pericarditis, heart failure or Budd-Chiari syndrome. Massive serositis as a presenting feature of SLE is rare. We describe two adult cases of new onset SLE presenting with massive ascites in the first case, and large bilateral pleural effusions in the second case. The serositis in both patients responded well to high dose steroid therapy with significant improvement in symptoms.

Citation: Geraldino-Pardilla L, Gartshteyn Y, Mendoza F (2015) Massive Serositis as the Initial Presentation of Systemic Lupus Erythe-matosus: A Report of Two Cases and Review of the Literature. J Rheum Dis Treat 1:028.



 Research Article 


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Published Date
December 17, 2015

Vol. 1, Issue 4

Aspirin-Triggered Resolvin D1 Versus Dexamethasone in the Treatment of Sjogren's Syndrome-Like NOD/ShiLtJ Mice - A Pilot Study

Justin T Easley, Joel W Nelson, Rachel E Mellas, Salah Sommakia, Chunhua Wu, Bryan Trump, and Olga J Baker

Corresponding author: Olga J. Baker, DDS, PhD, School of Dentistry, University of Utah, 383 Colorow Dr. Room 289A, Salt Lake City, UT 84108-1201, USA

Resolvin D1 (RvD1) and its aspirin-triggered epimeric form (AT-RvD1) are endogenous lipid mediators (derived from docosahexaenoic acid, DHA) that control the duration and magnitude of inflammation in models of complex diseases. Our previous studies demonstrated that RvD1-mediated signaling pathways are expressed and active in salivary glands from rodents and humans. Furthermore, treatment of salivary cells with RvD1 blocked TNF- -mediated inflammatory signals and improved epithelial integrity. The purpose of this pilot study was to determine the feasibility of treatment with AT-RvD1 versus dexamethasone (DEX) on inflammation (i.e., lymphocytic infiltration, cytokine expression and apoptosis) observed in submandibular glands (SMG) from the NOD/ShiLtJ Sjogren's syndrome (SS) mouse model before experimenting with a larger population.

Citation: Easley JT, Nelson JW, Mellas RE, Sommakia S, Wu C, et al. (2015) Aspirin-Triggered Resolvin D1 Versus Dexamethasone in the Treatment of Sjogren's Syndrome-Like NOD/ShiLtJ Mice - A Pilot Study. J Rheum Dis Treat 1:027.



 Case Report 


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Published Date
November 18, 2015

Vol. 1, Issue 4

A Rare Coexistence of Seronegative Enthesopathy and Arthropathy Syndrome with Familial Mediterranean Fever

Hakan Genc, Alper Gumustepe, Fikriye Figen Ayhan and Aynur Karagoz

Corresponding author: Hakan Genc, Physical Medicine and Rehabilitation Clinic, Ankara Training and Research Hospital, Ulucanlar Street, 06030 Altindag/Ankara, Turkey

The juvenile-onset spondyloarthropathies begin at age of 16 years or younger and are associated with the HLA-B27 allele. They are classified as the enthesitis-related arthritis (ERA) subgroup of juvenile idiopathic arthritis (JIA) by the international league of associations for rheumatology (ILAR) [1]. Although the adult form has inflammatory low back pain as the predominant clinical symptom, the juvenile form has peripheral enthesitis and arthritis as its main clinical features. For this reason, Rosenberg and Petty proposed the concept of the seronegative enthesopathy and arthropathy (SEA) syndrome.

Citation: Genc H, Gumustepe A, Ayhan FF, Karagoz A (2015) A Rare Coexistence of Seronegative Enthesopathy and Arthropathy Syndrome with Familial Mediterranean Fever. J Rheum Dis Treat 1:026.



 Case Report 


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Published Date
November 18, 2015

Vol. 1, Issue 4

In the Idiopathic Inflammatory Myopathies, How Significant is Creatine Kinase Levels in Diagnosis and Prognosis? A Case Study and Review of the Literature

Travis C Sizemore

Corresponding author: Travis C Sizemore, Department of Internal Medicine, University South Carolina Greenville Health System, 701 Grove Rd, Greenville, SC 29605, USA

The clinical significance of creatine kinase [CK] levels in idiopathic inflammatory myopathies [IIM] has varied between studies. CK levels continue to be the most sensitive laboratory marker for muscle disease in IIM but vary depending upon the disease entity. The goal of this article was to further elucidate the clinical significance of CK levels in the setting of IIM, including role of CK in diagnostics and prognostication. A case report was described with a subsequent literature review completed by searching within high quality peer-reviewed articles in the Cochrane Review database as well as Medline 1975-2015 with Key words creatine kinase, idiopathic inflammatory myopathies, polymyositis, and dermatomyositis.

Citation: Sizemore TC (2015) In the Idiopathic Inflammatory Myopathies, How Significant is Creatine Kinase Levels in Diagnosis and Prognosis? A Case Study and Review of the Literature. J Rheum Dis Treat 1:025.



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Published Date
November 16, 2015

Vol. 1, Issue 4

Hypercoagulation in Patients with Rheumatoid Arthritis Correlates with Activation of Act1/NF-kb Signaling Pathway

Pingheng Zhang, Jian Liu and Bing Tan

Corresponding author: Jian Liu, Department of Rheumatism Immunity, The First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei (230031), China

Peripheral blood samples were taken from 30 RA patients and 20 healthy volunteers, as controls. Ex vivo correlates of disease severity, such as C-reactive protein, erythrocyte sedimentation rate, anti-cyclic citrullinated peptide and rheumatoid factor, and immunological activation, such as interleukin (IL)-10, IL-17 and IL-6 were measured biochemically. Factors derived from the coagulation fibrinolytic system were also determined, such as the number of platelets, platelet activating factor, platelet activating factor-acetylhydrolase, D-dimer, thrombin time, prothrombin time, partial thromboplastin time, and fibrinogen levels.

Citation: Zhang P, Liu J, Tan B (2015) Hypercoagulation in Patients with Rheumatoid Arthritis Correlates with Activation of Act1/NF-kb Signaling Pathway. J Rheum Dis Treat 1:024.



 Original Article 


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Published Date
October 31, 2015

Vol. 1, Issue 4

Fatigue in Patients with Early-Stage Systemic Lupus Erythematosus Before Receiving Corticosteroid Therapy: A Prospective Cross-Sectional Study

Katsuji Nishimura, Masako Omori, Yasuhiro Katsumata, Eri Sato, Yasushi Kawaguchi, Masayoshi Harigai, Hisashi Yamanaka and Jun Ishigooka

Corresponding author: Dr. Katsuji Nishimura, Department of Psychiatry, Tokyo Women's Medical University School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan

Objective: Fatigue has been intensively studied in patients with systemic lupus erythematosus (SLE). However, previous studies have mostly included patients with long-term disease who have been treated with corticosteroids. We investigated fatigue in corticosteroid-naive patients with early-stage SLE. Methods: Forty-three SLE inpatients without neuropsychiatric SLE manifestations and 30 healthy control subjects with similar demographic characteristics participated in this study. The Profile of Mood States (POMS) was used to assess fatigue, depression and anxiety. Results of clinical, laboratory, and neurological tests were compared and their relationship with fatigue was assessed.

Citation: Nishimura K, Omori M, Katsumata Y, Sato E, Kawaguchi Y, et al. (2015) Fatigue in Patients with Early-Stage Systemic Lupus Erythematosus Before Receiving Corticosteroid Therapy: A Prospective Cross-Sectional Study. J Rheum Dis Treat 1:023.



 Review Article 


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Published Date
September 28, 2015

Vol. 1, Issue 3

Lupus-Associated Pancreatitis: Clinical Aspects

Maria Helena Favarato

Corresponding author: Maria Helena Favarato, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil

Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory disease, with several different clinical manifestations. Its annual incidence is about 5 cases per 100000 inhabitants. The prevalence is around 52 cases per 100000 inhabitants. The gastrointestinal tract may be affected, either by the disease itself or by adverse reactions of medications or by opportunistic infections. Although common, the incidence of gastrointestinal manifestations may be underestimated, as the symptoms may be absent or nonspecific.

Citation: Favarato MH (2015) Lupus-Associated Pancreatitis: Clinical Aspects. J Rheum Dis Treat 1:022.



 Case Report 


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Published Date
September 28, 2015

Vol. 1, Issue 3

Eosinophilic Fasciitis Treated with Tocilizumab: Demonstration of Efficacy after Withdrawal and Re-Challenge in a Patient

Glen T D Thomson, Janine L Johnston and Brent R J Thomson

Corresponding author: Glen T D Thomson, Department of Family Medicine, University of Manitoba and CIADS Research, 1835 Corydon Avenue, Winnipeg, Manitoba, Canada

A 41-year-old man presented with clinical features of eosinophilic fasciitis (EF) confirmed on biopsy. The patient responded to high-dose prednisone but subsequent steroid sparing medication including methotrexate, hydroxychloroquine, etanercept, golimumab and rituximab failed to deliver steroid sparing response. Tocilizumab provided rapid and sustained improvement in the patient's symptoms and signs. Withdrawal of tocilizumab resulted in a flare of the clinical manifestations of EF; retreatment provided rapid recovery. Tocilizumab appears to have a therapeutic benefit in treatment resistant EF.

Citation: Thomson GTD, Johnston JL, Thomson BRJ (2015) Eosinophilic Fasciitis Treated with Tocilizumab: Demonstration of Efficacy after Withdrawal and Re-Challenge in a Patient. J Rheum Dis Treat 1:021.



 Case Report 


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Published Date
September 24, 2015

Vol. 1, Issue 3

A Case of Rhabdomyolysis and Polyarticular Inflammatory Arthritis May be the Initial Presentation of Chronic Myelogenous Leukemia (CML)

Yelliann Ruiz-Irizarry and Petros Efthimiou

Corresponding author: Yelliann Ruiz-Irizarry, Internal Medicine PGY-3, New York Methodist Hospital, Weill Cornell College of Medicine Affiliate, USA

Rhabdomyolysis and inflammatory arthritis are common rheumatologic conditions that manifest in people of all ages. Proximal muscle weakness associated to rhabdomyolysis is frequently the initial presentation of inflammatory myopathies such as dermatomyositis (DM) and polymyosistis (PM) both, extensively described in literature to be related to paraneoplastic process. Inflammatory arthritis has been associated to certain paraneoplastic syndromes, but not in relation to Chronic Meylogenous Leukemia (CML).

Citation: Ruiz-Irizarry Y, Efthimiou P (2015) A Case of Rhabdomyolysis and Polyarticular Inflammatory Arthritis May be the Initial Presentation of Chronic Myelogenous Leukemia (CML). J Rheum Dis Treat 1:020.



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Published Date
September 09, 2015

Vol. 1, Issue 3

A MRI Assessment of the Response of Chronic, Occult, Synovial-Based Inflammation of Gout to Serum Urate Lowering Therapy

John D. Carter, Michelle Patelli, Scott R. Anderson, Neelesh Prakash, Ernesto J. Rodriquez and Louis R. Ricca

Corresponding author: John D. Carter, M.D. University of South Florida; Tampa, FL, USA, 12901 Bruce B. Downs Blvd, MDC 81, Tampa, FL 33612, USA

Clinical gout begins as an acute intermittent and intensely painful arthritis that can progress to a chronic, inflammatory, destructive condition. The initial episodes may last several days and are often followed by pain-free, inter-critical periods that may last months to years. Chronic gouty arthritis is manifested by shorter inter-critical periods, boney destructive changes and possible development of visible tophi. Advanced gout leads to chronic pain, decreased quality of life, and an increased global economic burden.

Citation: Carter JD, Patelli M, Anderson SR, Prakash N, Rodriquez EJ, et al. (2015) A MRI Assessment of the Response of Chronic, Occult, Synovial-Based Inflammation of Gout to Serum Urate Lowering Therapy. J Rheum Dis Treat 1:019.



 Letter 


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Published Date
August 03, 2015

Vol. 1, Issue 3

A Flowchart For Understandıng Ankylosing Spondylitis Management Recommendatıons of Asas/Eular

Nihal Ozaras

Corresponding author: Nihal Ozaras, Department of Physical Medicine and Rehabilitation, Bezmialem Vakif University of Istanbul, Turkey

Ankylosing spondylitis (AS) is one of the most frequently seen rheumatic diseases in clinical practice. Its treatment is defied by the Assessment of SpondyloArthritis international Society (ASAS)/ European League Against Rheumatism (EULAR). A flowchart is designed to easily understand this treatment strategy.

Citation: Ozaras N (2015) A Flowchart For Understandıng Ankylosing Spondylitis Management Recommendatıons of Asas/Eular. J Rheum Dis Treat 1:018.



 Case Report 


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Published Date
July 17, 2015

Vol. 1, Issue 3

Pathological Relationship of Osteomalacia at the Site of Atypical Periprosthetic Femoral Shaft Fracture after Typical Femoral Neck Fracture Occurred in the Patient with Rheumatoid Arthritis: A Case Report

Takanori Wakayama, Yoshitomo Saita, Tomonori Baba, Hidetoshi Nojiri and Kazuo Kaneko

Corresponding author: Yoshitomo Saita, Assistant Professor, Department of Orthopaedics, Juntendo University School of Medicine, Tokyo, Japan

We describe a patient who suffered an atypical periprosthetic femoral shaft fracture two years after surgical treatment for a typical osteoporotic femoral neck fracture. This patient had been suffering from rheumatoid arthritis (RA), steroid-induced diabetes, and steroid-induced osteoporosis, and had undergone long term administration of glucocorticoids (GCs), bisphosphonates (BPs), and active vitamin D (aVD) analog. Prodromal pain and periprosthetic cortical stress reaction had occurred in the lateral cortex one month before she sustained the complete fracture. Histomorphometric analysis of a bone taken from just beneath the fracture site revealed the involvement of not severely suppressed bone turnover (SSBT) but osteomalacia.

Citation: Wakayama T, Saita Y, Baba T, Nojiri H, Kaneko K (2015) Pathological Relationship of Osteomalacia at the Site of Atypical Periprosthetic Femoral Shaft Fracture after Typical Femoral Neck Fracture Occurred in the Patient with Rheumatoid Arthritis: A Case Report. J Rheum Dis Treat 1:017.



 Case Report 


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Published Date
July 09, 2015

Vol. 1, Issue 3

A Case of Malignant Malaria Complicated By Symmetrical Peripheral Gangrene

Amira A Shahin, Noha M Abdelbaky and Sahar S Emam

Corresponding author: Prof. Amira A. Shahin, Department of Rheumatology and Rehabilitation, Faculty of Medicine, Cairo University, Cairo, Egypt

Symmetrical peripheral gangrene (SPG) is a rare complication of malaria. The ischemic changes begin distally and progress rapidly to cause irreversible tissue necrosis requiring amputation in almost all cases. We report a case of a 21-years-old female with malignant malaria complicated by SPG. Our treatment regimen includes corticosteroids in addition to the anti-malaria and anticoagulation therapy. Clinicians should be aware of this entity as early recognition can help in reducing morbidity and mortality.

Citation: Shahin AA, Abdelbaky NM, Emam SS (2015) A Case of Malignant Malaria Complicated By Symmetrical Peripheral Gangrene. J Rheum Dis Treat 1:016.



 Review Article 


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Published Date
July 03, 2015

Vol. 1, Issue 3

Anxiety and its Impact on Osteoarthritis Pain: An Update

Prof. Ray Marks

Prof. Ray Marks, Departments of Health, Physical Education & Gerontological Studies and Services, City University of New York, York College; Health and Behavior Studies, Columbia University, Teachers College, New York, USA

Anxiety is a very common psychological syndrome occurring in the adult population either as a trait or specific condition, and/or in response to a variety of situations, especially adverse health conditions. This narrative review examines the extent to which anxiety may preside among adults with a diagnosis of osteoarthritis, regardless of site, and its linkage to the pain experience. Drawn from the English language peer reviewed work over the last 35 years, articles that focused on the topic of anxiety among cases with osteoarthritis were examined.

Citation: Marks R (2015) Anxiety and its Impact on Osteoarthritis Pain: An Update. J Rheum Dis Treat 1:015.



 Case Report 


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Published Date
June 11, 2015

Vol. 1, Issue 2

Treatment of Refractory Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis with High Dose Anakinra

Kwong Jenitta M, Peng Tammy, Mohiuddin Adil, Chefiz Dalya, Craig Vicki, Weissmann David, Moorthy L Nandini, Weiss Pamela F, Cron Randy Q and Andujar Joanna

Corresponding author: Peng Tammy, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA

We report a case of MAS occurring during the initial presentation of sJIA treated with high dose anakinra. Excess interleukin-1 can lead to the clinical and laboratory findings of sJIA and MAS, and the up regulation of interleukin-6. Uncontrolled production and activation of macrophages and T lymphocytes lead to MAS manifestations, including prolonged high fever, pancytopenia, coagulopathy, lymphadenopathy, hepatic insufficiency, and neurologic dysfunction.

Citation: Kwong JM, Tammy P, Adil M, Dalya C, Vicki C, et al. (2015) Treatment of Refractory Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis with High Dose Anakinra. J Rheum Dis Treat 1:014.



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Published Date
May 23, 2015

Vol. 1, Issue 2

Effect of Etanercept on Anti-Carbamylated Protein Antibodies in Patients with Rheumatoid Arthritis

Francesca Romana Spinelli, Arbi Pecani, Fulvia Ceccarelli, Cristiano Alessandri and Fabrizio Conti

Corresponding author: Conti Fabrizio, Department of Internal Medicine and Medical Specialities - Rheumatology, Sapienza University of Rome, Viale del Policlinico 155 - 00161 Rome, Italy

Rheumatoid Arthritis (RA) is a systemic, chronic inflammatory disease characterized by inflammation of synovial joints and production of autoantibodies such as Rheumatoid Factor and antibodies directed against modified proteins - i.e. anti-citrullinated peptides antibody (ACPA). Carbamylation, as a post translational modification, has been recently associated to RA since anticarbamylated protein antibodies (anti-CarP) have been detected in the sera of RA patients. The effect of treatment on anti-CarP level has been never addressed before.

Citation: Spinelli FR, Pecani A, Ceccarelli F, Alessandri C, Conti F (2015) Effect of Etanercept on Anti-Carbamylated Protein Antibodies in Patients with Rheumatoid Arthritis. J Rheum Dis Treat 1:013.



 Review Article 


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Published Date
May 22, 2015

Vol. 1, Issue 2

Pathogenesis of Bone Erosions in Rheumatoid Arthritis: Not Only Inflammation

Maurizio Rossini, Angelo Fassio, Luca Idolazzi, Ombretta Viapiana, Elena Fracassi, Giovanni Adami, Maria Rosaria Povino, Maria Vitiello and Davide Gatti

Corresponding author: Maurizio Rossini, Department of Medicine, Rheumatology Unit, Policlinico Borgo Roma, Piazzale Scuro, 10, 37134, Verona, Italy

It is a matter of fact that the inflammatory pathogenesis does not explain all the skeletal manifestations of Rheumatoid Arthritis (RA), and the development of bone involvement is sometimes unconnected from the clinical scores of inflammation. On the basis of recent studies, we would like to make a point of the new available evidence about the metabolic pathogenic component of bone erosions.

Citation: Rossini M, Fassio A, Idolazzi L, Viapiana O, Fracassi E, et al. (2015) Pathogenesis of Bone Erosions in Rheumatoid Arthritis: Not Only Inflammation. J Rheum Dis Treat 1:012.



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Published Date
May 21, 2015

Vol. 1, Issue 2

Screening for Mucopolysaccharidoses in Pediatric Rheumatology Clinic

Magrini D, Lehman TJA and Moorthy LN

Corresponding author: LN Moorthy, Division of Pediatric Rheumatology, Department of Pediatrics, Rutgers-RWJ Medical School, 89 French Street, New Brunswick, USA

Mucopolysaccharidosis (MPS) is a rare group of inherited lysosomal storage disorders that is associated with multiple symptoms including joint stiffness, misshapen bones, reduced hand function, frequent otitis media, 'thickened' facial features, hearing problems, vision problems and heart complications. We conducted this study to determine how many (if any) children that come to pediatric rheumatology have unrecognized MPS and if routine screening for MPS is needed.

Citation: Magrini D, Lehman TJA, Moorthy LN (2015) Screening for Mucopolysaccharidoses in Pediatric Rheumatology Clinic. J Rheum Dis Treat 1:011.



 Editorial 


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Published Date
May 13, 2015

Vol. 1, Issue 2

Spondyloarthropathy, Spondyloarthritis, Axial Spondyloarthritis: A Rose by any other Name?

Bruce Rothschild

Corresponding author: Bruce Rothschild, Department of Medicine, Northeast Ohio Medical University, Rootstown, Ohio 44272 and Carnegie Museum, 4400 Forbes Ave, Pittsburgh PA, 15273, USA

What is a diagnosis, but recognition of a phenotype? The term spondyloarthropathy is much debated, with alternative appellation suggestions. Spondyloarthritis and spondylarthritis have been suggested, but there has also been a movement to separate peripheral and axial disease, with the latter referred to as axial spondyloarthropathy.

Citation: Rothschild B (2015) Spondyloarthropathy, Spondyloarthritis, Axial Spondyloarthritis: A Rose by any other Name? J Rheum Dis Treat 1:010e.



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Published Date
April 13, 2015

Vol. 1, Issue 2

Tei Index in a Sample of Patients with Ankylosing Spondylitis

Rodrigo Eduardo Rosa, Admar Moraes de Souza, Lucio Ricardo Hiurko Felippe, Pedro Grachinski Buiar, Pedro Gabriel Lorencetti, Chayanne Natielle Rossetto and Valderilio Feijo Azevedo

Corresponding author: Valderilio Feijo Azevedo, Department of Rheumatology at UFPR, Head of Spondyloarthritis clinic at HC-UFPR, Curitiba, Parana, Brazil

Ankylosing spondylitis (AS) is an inflammatory disease of immunological origin which has been correlated with higher cardiovascular risk. Although the risk factors are not clear, many cardiac alterations have been described, such as conduction disturbances, coronary heart disease, aortic root dilation, cardiac valve alterations, and ventricular diastolic dysfunction.

Citation: Rosa RE, de Souza AM, Felippe LRH, Buiar PG, Lorencetti PG, et al. (2015) Tei Index in a Sample of Patients with Ankylosing Spondylitis. J Rheum Dis Treat 1:009.



 Review Article 


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Published Date
April 09, 2015

Vol. 1, Issue 2

Osteoimmunological Aspects on Inflammation and Bone Metabolism

Uwe Lange, Gabriel Dischereit, Elena Neumann, Klaus Frommer, Ingo H. Tarner and Ulf Muller-Ladner Kerckhoff-Klinik

Corresponding author: Professor Uwe Lange, Department of Rheumatology, Osteology and Physical Medicine, University of Giessen, Germany

Bone remodelling is characterized by a balance between bone resorption and bone formation. The osteoblasts are responsible for bone synthesis and the osteoclasts for bone resorption. A finely adjusted interaction between molecular mechanisms results, via cytokines, hormones and growth factors, in homeostasis of bone metabolism.

Citation: Lange U, Dischereit G, Neumann E, Frommer K, Tarner IH, et al. (2015) Osteoimmunological Aspects on Inflammation and Bone Metabolism. J Rheum Dis Treat 1:008.



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