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 Research Article 


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Published Date
August 19, 2016

Vol. 3, Issue 2

Protease Biosensors Based on Peptide-Nanocellulose Conjugates: From Molecular Design to Dressing Interface

J Vincent Edwards, Krystal R Fontenot, Nicolette T Prevost, David Haldane, Nicole Pircher, Falk Liebner, Alfred French and Brian D Condon

Corresponding author: J Vincent Edwards, Cotton Chemistry and Utilization Research, United States Department of Agriculture, 1100 Robert E. Lee Blvd, New Orleans, LA 70124, USA

The development of point of care diagnostic protease sensors applied to wound healing has received increased interest in chronic wound treatment as an interface for chronic wound dressings. Biosensor technology and the use of nanomaterials have grown exponentially in recent years. A biosensor is fundamentally a biomolecule (functioning as a transducer) attached to a transducer surface, which is activated by a biochemical property that prompts a detection signal specific to a target biomarker. For instance, nanomaterials are often derivatized with a biomolecule that provides selectivity and sensitivity for diagnostic biomarkers.

Citation: Edwards JV, Fontenot KR, Prevost NT, Haldane D, Pircher N, et al. (2016) Protease Biosensors Based on Peptide-Nanocellulose Conjugates: From Molecular Design to Dressing Interface. Int J Med Nano Res 3:018.



 Short Commentary 


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Published Date
February 09, 2016

Vol. 3, Issue 1

Ovarian Cancer Treatment by Suicide Gene Therapy: Beauty of Nanotechnology in Medicine

Abhimanyu Thakur, Mahadi Hasan MA Shahed, Aishwarya Roy and Nabila Sayed

Corresponding author: Dr. Mahadi Hasan MA Shahed, Department of Biomedical Sciences, City University of Hong Kong, 83, Tat Chee Avenue, Hong Kong SAR

There has been a global interest worldwide in the recent trend of medical researches, which is basically a merge up between basic biology and engineering tools/technology. Imaging, microfluidics, nanofluidics, surface plasmon resonance (SPR) sensor systems, etc. are the widely used engineering tools in medical researches and has given effective clinical results. The most effective and widely used technology amongst these would be nanotechnology which employs methods like nano drug delivery, nano detection of tumors, assay methods, to detect tumor cells, reach the desired target and kill the tumors.

Citation: Thakur A, Shahed MHMA, Roy A, Sayed N (2016) Ovarian Cancer Treatment by Suicide Gene Therapy: Beauty of Nanotechnology in Medicine. Int J Med Nano Res 3:017.



 Research Article 


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Published Date
February 02, 2016

Vol. 3, Issue 1

Studying Complex Interaction of B2H4 with HOR(R = H, CH3) and Nhn(CH3)3-N (N = 0-3) Molecules

Reza Tayebee and Abedien Zabardasti

Corresponding author: Reza Tayebee, Department of Chemistry, School of Sciences, Hakim Sabzevari University, Sabzevar, Iran

Borane complexes are extensively studied and have even been the subject of Nobel Prize by Brown [1]. Many scientific data exist that have shown that boron is an essential microelement in animal cells. With the knowledge that borate linkages function in cell-to-cell adhesion, it has been hypothesised that boronates target structural glycoproteins located along the cytoskeletonplasma membrane-cell wall assembly.

Citation: Tayebee R, Zabardasti A (2016) Studying Complex Interaction of B2H4 with HOR(R = H, CH3) and Nhn(CH3)3-N (N = 0-3) Molecules. Int J Med Nano Res 3:016.



 Review Article 


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Published Date
January 29, 2016

Vol. 3, Issue 1

Nanoparticles: From Diagnosis to Therapy

Derya Ilem-Ozdemir, Evren Gundogdu, Meliha Ekinci and Makbule Asikoglu

Corresponding author: Derya Ilem-Ozdemir, Faculty of Pharmacy, Department of Radiopharmacy, Ege University, Bornova, Izmir, Turkey

Cancer is a leading cause of death, the second most common cause, exceeded only by heart disease. Still, the current clinical imaging methods and treatments are in many situations unable to provide timely detection and curative therapy. The field of drug delivery stands to be significant advances in nanotechnology and benefits of novel nanotechnology in oncology already starts. New strategies are being designed to deliver chemotherapeutic drugs or imaging agents to the tumor at higher concentrations with minimal damage to normal tissues. This review will focus on how nanoparticles are able to function as carriers for chemotherapeutic drugs to increase their therapeutic index; how can be used as imaging agents to detect and monitor cancer progression.

Citation: Ilem-Ozdemir D, Gundogdu E, Ekinci M, Asikoglu M (2016) Nanoparticles: From Diagnosis to Therapy. Int J Med Nano Res 3:015.



 Review Article 


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Published Date
December 30, 2015

Vol. 3, Issue 1

Estimating Binding Capability of Radiopharmaceuticals by Cell Culture Studies

Derya Ilem-Ozdemir, Meliha Ekinci, Evren Gundogdu and Makbule Asikoglu

Corresponding author: Derya Ilem-Ozdemir, Faculty of Pharmacy, Department of Radiopharmacy, Ege University, 35100 Bornova, Izmir, Turkey

Radiopharmaceuticals have applications in biologic research, drug discovery, diagnosis of human disease and molecular therapeutics for a wide variety of medical conditions. With the increasingly central role of radiotracers for non-invasive imaging of animal models and human research, small animal imaging centers are likely to have a growing interest in development of radiopharmaceutical science. Although animal experiments are giving the most valuable information about the drug behavior in the biological system. Also every year, millions of experimental animals are used all over the world.

Citation: Ilem-Ozdemir D, Ekinci M, Gundogdu E, Asikoglu M (2015) Estimating Binding Capability of Radiopharmaceuticals by Cell Culture Studies. Int J Med Nano Res 2:014.



 Review Article 


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Published Date
December 01, 2015

Vol. 3, Issue 1

Modification of the Uranyl Acetate Replacement Staining Protocol for Transmission Electron Microscopy

Santhana Raj L, Paramsavaran S, Koay BT, Izan Shahrina A and Siti Aminah N

Corresponding author: Santhana Raj L, Electron Microscopy Unit, Medical Resource Research Centre, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia

A uranyl acetate replacement staining protocol has eliminated the need for highly toxic uranyl acetate in the electron microscopy laboratory. However, the method is results in undesirable charging effects when viewed under the transmission electron microscope and can be further improved. A modification of the uranyl acetate replacement staining protocol that simplifies the process is described. The modified method takes less time, and produces better contrast and less charging effects compared to the existing uranyl acetate replacement staining protocol.

Citation: Santhana RL, Paramsavaran S, Koay BT, Izan SA, Siti AN (2015) Modification of the Uranyl Acetate Replacement Staining Protocol for Transmission Electron Microscopy. Int J Med Nano Res 2:013.



 Research Article 


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Published Date
November 02, 2015

Vol. 2, Issue 2

Bio-Active Designer Materials and Dentures: from Design to Application

V Tamara Perchyonok, John Souza, Shengmiao Zhang, Desigar Moodley and Sias Grobler

Corresponding author: V Tamara Perchyonok, VTPCHEM PTY LTD, Glenhuntly, Melbourne, Australia

The bio-active modified polymethyl methacrylate denture resins (PMMA) were prepared by dispersion of the corresponding component in glycerol and acetic acid with the addition of chitosan gelling agent. The release behaviors at physiological pH and also under acidic conditions and stability of the antioxidant-chitosan were also evaluated. Mechanical performance such as tensile strength and compressive strength were measured as well bio-adhesive studies were investigated in order to assess the suitability of these designer materials.

Citation: Perchyonok VT, Souza J, Zhang S, Moodley D, Grobler S (2015) Bio-Active Designer Materials and Dentures: from Design to Application. Int J Med Nano Res 2:012.



 Research Article 


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Published Date
September 21, 2015

Vol. 2, Issue 2

Facile DNA Detection Based on Fluorescence Switching of A Hydrophobic AIE Dye-Labeled Peptide Nucleic Acid Probe by Aggregation/Disaggregation

Koji Kawamura, Ai Matsumoto and Takashi Murashima

Corresponding author: Takashi Murashima, Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Japan

A novel, facile DNA detection method based on aggregation/disaggregation of an AIE (aggregation induced emission) dye-labeled peptide nucleic acid (PNA) probe was developed. This PNA probe plays the role of both target recognition and signal emission, thus it can quantify the target DNA without requiring additives such as intercalators and can distinguish the target from other sequences.

Citation: Kawamura K, Matsumoto A, Murashima T (2015) Facile DNA Detection Based on Fluorescence Switching of A Hydrophobic AIE Dye-Labeled Peptide Nucleic Acid Probe by Aggregation/Disaggregation. Int J Med Nano Res 2:011.



 Review Article 


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Published Date
September 17, 2015

Vol. 2, Issue 2

Biomedical Applications of Natural Polymer Based Nanofibrous Scaffolds

Preethi GU, Manu M Joseph, Unnikrishnan BS, Shiji R and Sreelekha TT

Corresponding author: Dr. T.T. Sreelekha PhD, Assistant Professor, Division of Cancer Research, Regional Cancer Centre, Trivandrum, Kerala-695011, India

Nanotechnology is one of the most popular branches of science in the current decade where nanofiber scaffolds (NS) attain principal attraction. NS are composed of several nanometer to micrometer diameter fibers similar in nature to collagen, keratin and elastin fibers of the extracellular matrix (ECM) and helps in cell attachment, proliferation and differentiation. NS with desired features can be fabricated using various chemical, physical and biological methods such as electrospinning, phase separation, self-assembly, templating etc.

Citation: Preethi GU, Joseph MM, Unnikrishnan BS, Shiji R, Sreelekha TT (2015) Biomedical Applications of Natural Polymer Based Nanofibrous Scaffolds. Int J Med Nano Res 2:010.



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International Journal of Cancer and Clinical Research (ISSN: 2378-3419)
International Journal of Clinical Cardiology (ISSN: 2469-5696)
Journal of Clinical Gastroenterology and Treatment (ISSN: 2469-584X)
Clinical Medical Reviews and Case Reports (ISSN: 2378-3656)
Journal of Dermatology Research and Therapy (ISSN: 2469-5750)
International Journal of Diabetes and Clinical Research (ISSN: 2377-3634)
Journal of Family Medicine and Disease Prevention (ISSN: 2469-5793)
Journal of Genetics and Genome Research (ISSN: 2378-3648)
Journal of Geriatric Medicine and Gerontology (ISSN: 2469-5858)
International Journal of Immunology and Immunotherapy (ISSN: 2378-3672)
International Journal of Medical Nano Research (ISSN: 2378-3664)
International Journal of Neurology and Neurotherapy (ISSN: 2378-3001)
International Archives of Nursing and Health Care (ISSN: 2469-5823)
International Journal of Ophthalmology and Clinical Research (ISSN: 2378-346X)
International Journal of Oral and Dental Health (ISSN: 2469-5734)
International Journal of Pathology and Clinical Research (ISSN: 2469-5807)
International Journal of Pediatric Research (ISSN: 2469-5769)
International Journal of Respiratory and Pulmonary Medicine (ISSN: 2378-3516)
Journal of Rheumatic Diseases and Treatment (ISSN: 2469-5726)
International Journal of Sports and Exercise Medicine (ISSN: 2469-5718)
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International Journal of Surgery Research and Practice (ISSN: 2378-3397)
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