Latest Articles | Contact

Home


Editorial Board


Recent Articles


Submit to this journal


Special Issues


Current issue



 Original Article 


Download PDF



View full article


Published Date
January 31, 2017

Vol. 4, Issue 1

Acetylation of α-tubulin by a Histone Deacetylase Inhibitor, Resminostat, Leads Synergistic Antitumor Effect with Docetaxel in Non-Small Cell Lung Cancer Models

Hiroaki Konishi, Akimitsu Takagi, Hiroyuki Takahashi, Satoru Ishii, Yu Inutake and Takeshi Matsuzaki

Corresponding author: Hiroaki Konishi, Yakult Central Institute, Yakult Honsha Co., Ltd., 5-11 Izumi, Kunitachi-shi, Tokyo 1860-8650, Japan

There is a growing body of clinical evidence to demonstrate that inhibition of histone deacetylase is effective in the treatment of various types of cancer. We examined whether acetylation of a non-histone protein α-tubulin was induced by resminostat and this acetylation exerts combination effects with docetaxel since α-tubulin was a target of docetaxel.

Citation: Konishi H, Takagi A, Takahashi H, Ishii S, Inutake Y, et al. (2017) Acetylation of α-tubulin by a Histone Deacetylase Inhibitor, Resminostat, Leads Synergistic Antitumor Effect with Docetaxel in Non-Small Cell Lung Cancer Models. Int J Cancer Clin Res 4:077.



 Original Article 


Download PDF



View full article


Published Date
January 30, 2017

Vol. 4, Issue 1

Trastuzumab Emtansine in Patients with HER2-Positive Metastatic Breast Cancer: a Multicenter Japanese Retrospective Study

Masako Sato, Masato Takahashi, Kenichi Watanabe, Nobumoto Tomioka, Mitsugu Yamamoto, Yoshiaki Narita, Hiroaki Kato, Masaru Abe, Yukiko Tabata, Masaya Kawada, Motoshi Tamura, Mitsuchika Hosoda, Motoi Baba, Kazuhiro Ogasawara, Tomohiro Oshino, Hiromitsu Akabane, Yasuhiro Suzuki, Masatoshi Kadoya, Kazuhiro Iwai, Yumi Okawa, Kenjiro Misu, Kazuomi Ichinokawa and Hiroko Yamashita

Corresponding author: Hiroko Yamashita, Department of Breast Surgery, Hokkaido University Hospital, Kita 14, Nishi 5, Kita-ku, Sapporo, 060-8648, Japan

Trastuzumab emtansine (T-DM1) is currently approved for the treatment of patients with HER2-positive metastatic breast cancer after failure of prior anti-HER2 therapies. However, the efficacy of T-DM1 in patients who received pertuzumab, and in those patients with brain metastases, is currently unclear.

Citation: Sato M, Takahashi M, Watanabe K, Tomioka N, Yamamoto M, et al. (2017) Trastuzumab Emtansine in Patients with HER2-Positive Metastatic Breast Cancer: a Multicenter Japanese Retrospective Study. Int J Cancer Clin Res 4:076.



 Research Article 


Download PDF



View full article


Published Date
December 01, 2016

Vol. 3, Issue 6

Cancer Antigen 125 Levels can be Used as a Tumor Marker for Monitoring Patients with Endometrial Serous Carcinoma?

MW Hegazy, Wael H Elsawy, A Tolba and M Shoukri

Corresponding author: Mohamed W Hegazy, Department of Radiation Oncology, King Faisal Specialist Hospital & Research Center, Kingdom of Saudi Arabia, PO Box 3354, Riyadh 11211 MBC 64, Saudi Arabia

Endometrial adenocarcinoma is the most common type of uterine cancer. Endometrial cancer is classified into two subtypes (I and II), which reflect general characteristics of its clinicopathological spectrum. Uterine serous adenocarcinoma (USAC) is under Type II neoplasms which are associated with more aggressive behavior than type I tumors. While they comprise 10-20% of endometrial carcinomas, they account for 40% of deaths from the disease.

Citation: Hegazy MW, Elsawy WH, Tolba A, Shoukri M (2016) Cancer Antigen 125 Levels can be Used as a Tumor Marker for Monitoring Patients with Endometrial Serous Carcinoma?. Int J Cancer Clin Res 3:075.



 Clinical Image 


Download PDF



View full article


Published Date
November 26, 2016

Vol. 3, Issue 6

Massive Arterial Bleeding after Lenvatinib Therapy for Thyroid Cancer

Koichi Suyama, DaizoMurakami, Saori Fujiwara, Takashi Takeshita, Aiko Sueta, ToukoInao, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Shin-yaShiraishi and Hirotaka Iwase

Corresponding author: Koichi Suyama, Kumamoto University Hospital Cancer Center, Graduate School of Life Sciences, Kumamoto University, 1-1-1, Honjyo, Chuo-ku, Kumamoto-city, 860-8556, Kumamoto, Japan

A 69-year-old woman presented with hoarseness and other symptoms of laryngeal stenosis. A palpably large tumorin her neck was shown by computed tomography (CT) to expand invasively from her upper left thyroid lobe, and to involve her left common carotid artery and internal jugular vein (Figure 1 A-1). The diagnosis of papillary thyroid cancer was based on cytological evidence from fine needle aspiration biopsy.

Citation: Suyama K, Murakami D, Fujiwara S, Takeshita T, Sueta A, et al. (2016) Massive Arterial Bleeding after Lenvatinib Therapy for Thyroid Cancer. Int J Cancer Clin Res 3:074.



 Short Review 


Download PDF



View full article


Published Date
November 26, 2016

Vol. 3, Issue 6

Pigmented Paget Disease of the Nipple: A Rare Breast Cancer Presentation

Santiago Sherwell-Cabello, Antonio Maffuz-Aziz, Silvia Natalia Lopez-Hernandez, Melissa Lizeth Flores-Cortes, Veronica Bautista-Pina and Sergio Rodriguez-Cuevas

Corresponding author: Santiago Sherwell-Cabello, Instituto de Enfermedades de la Mama, FUCAM AC, Bordo 100, StaUrsula Coapa, Coyoacan 04980, Mexico City, Mexico

Institutional board approval was obtained before commencement of this study. A retrospective study was conducted in all women diagnosed with breast cancer at our institution from January 2005 to December 2013. Standard immunohistochemical breast cancer panel was performed to all patients (ER, PR, Her-2 and Ki-67) and CK-7, P63 and S-100 when the pigmented variety was presented. Patients with pigmented Paget disease were selected and demographic characteristics were established.

Citation: Sherwell-Cabello S, Maffuz-Aziz A, Lopez-Hernandez SN, Flores-Cortes ML, Bautista-Pina V, et al. (2016) Pigmented Paget Disease of the Nipple: A Rare Breast Cancer Presentation. Int J Cancer Clin Res 3:073.



 Review Article 


Download PDF



View full article


Published Date
November 19, 2016

Vol. 3, Issue 6

Colorectal Cancer Aggressiveness is Related to Fibronectin Over Expression, Driving the Activation of SDF-1:CXCR4 Axis

Sofia Gouveia-Fernandes, Tania Carvalho, Germana Domingues, Renata Bordeira-Carrico, Sergio Dias and Jacinta Serpa

Corresponding author: Jacinta Serpa, Centro de Estudos de Doencas Cronicas (CEDOC), NOVA Medical School, Universidade NOVA de Lisboa Campo Martires da Patria 130, 1169-056 Lisbon, Portugal

Cancer hallmarks result from dynamical interactions between tumor cells and tumor microenvironment, including normal cells, growth factors and extracellular matrix (ECM) components. Fibronectin (FN) is a high molecular weight, multidomain glycoprotein, present as a soluble form in body fluids, such as plasma (plasma FN), and as an insoluble form in ECM (cellular FN).

Citation: Gouveia-Fernandes S, Carvalho T, Domingues G, Bordeira-Carrrico R, Sergio Dias, et al. (2016) Colorectal Cancer Aggressiveness is Related to Fibronectin Over Expression, Driving the Activation of SDF-1:CXCR4 Axis. Int J Cancer Clin Res 3:072.



 Case Report 


Download PDF



View full article


Published Date
November 16, 2016

Vol. 3, Issue 6

Prolonged Use of Aprepitant in Metastatic Breast Cancer and a Reduction in CA153 Tumour Marker Levels

Mark Lee, Matthew McCloskey and Stephanie Staples

Corresponding author: Mark Lee, St Benedict's Hospice, St Benedict's Way, Ryhope, Sunderland SR2 0NY, UK

Nausea and vomiting are common problems in patients with advanced cancer. This case report describes a patient whose refractory nausea and vomiting improved significantly with the use of Aprepitant, a highly selective neurokinin 1 receptor antagonist. This improvement led to prolonged daily administration, during which time no chemotherapy or hormone therapy was administered. CA153 tumour markers were noted to have fallen during administration.

Citation: Lee M, McCloskey M, Staples S (2016) Prolonged Use of Aprepitant in Metastatic Breast Cancer and a Reduction in CA153 Tumour Marker Levels. Int J Cancer Clin Res 3:071.



International Journal of Anesthetics and Anesthesiology (ISSN: 2377-4630)
International Journal of Blood Research and Disorders   (ISSN: 2469-5696)
International Journal of Brain Disorders and Treatment (ISSN: 2469-5866)
International Journal of Cancer and Clinical Research (ISSN: 2378-3419)
International Journal of Clinical Cardiology (ISSN: 2469-5696)
Journal of Clinical Gastroenterology and Treatment (ISSN: 2469-584X)
Clinical Medical Reviews and Case Reports (ISSN: 2378-3656)
Journal of Dermatology Research and Therapy (ISSN: 2469-5750)
International Journal of Diabetes and Clinical Research (ISSN: 2377-3634)
Journal of Family Medicine and Disease Prevention (ISSN: 2469-5793)
Journal of Genetics and Genome Research (ISSN: 2378-3648)
Journal of Geriatric Medicine and Gerontology (ISSN: 2469-5858)
International Journal of Immunology and Immunotherapy (ISSN: 2378-3672)
International Journal of Medical Nano Research (ISSN: 2378-3664)
International Journal of Neurology and Neurotherapy (ISSN: 2378-3001)
International Archives of Nursing and Health Care (ISSN: 2469-5823)
International Journal of Ophthalmology and Clinical Research (ISSN: 2378-346X)
International Journal of Oral and Dental Health (ISSN: 2469-5734)
International Journal of Pathology and Clinical Research (ISSN: 2469-5807)
International Journal of Pediatric Research (ISSN: 2469-5769)
International Journal of Respiratory and Pulmonary Medicine (ISSN: 2378-3516)
Journal of Rheumatic Diseases and Treatment (ISSN: 2469-5726)
International Journal of Sports and Exercise Medicine (ISSN: 2469-5718)
International Journal of Stem Cell Research & Therapy (ISSN: 2469-570X)
International Journal of Surgery Research and Practice (ISSN: 2378-3397)
Trauma Cases and Reviews (ISSN: 2469-5777)
International Archives of Urology and Complications (ISSN: 2469-5742)
International Journal of Virology and AIDS (ISSN: 2469-567X)
More Journals

Contact Us

ClinMed International Library | Science Resource Online LLC
113 Barksdale Professional Center, Newark, DE 19711, USA
Email: contact@clinmedlib.org
Tel: +1-302-294-0935  

Feedback

Get Email alerts
 
Creative Commons License
Open Access
by ClinMed International Library is licensed under a Creative Commons Attribution 4.0 International License based on a work at https://clinmedjournals.org/.
Copyright © 2017 ClinMed International Library. All Rights Reserved.