Open Access DOI:10.23937/2378-3419/1410178
Expression Levels of GHRH-Receptor, pAkt and Hsp90 Predict 10-Year Overall Survival in Patients with Locally Advanced Rectal Cancer
Dávid Fodor, Eva Pozsgai, Andrew V. Schally, Zoltán László, Éva Gömöri, Éva Szabó, László Rumi, Dorottya Lőcsei, Árpád Boronkai and Szabolcs Bellyei
Article Type: Review Article | First Published: December 31, 2022
Rectal cancer constitutes nearly one-third of all colorectal cancer diagnoses and certain clinical and molecular markers have been studied as potential prognosticators of patient survival. The main objective of our study was to investigate the relationship between the expression intensities of certain proteins: Growth Hormone- Releasing Hormone Receptor (GHRH-R), Hsp90, Hsp16.2, p-Akt and SOUL in specimens of locally advanced rectal cancer patients and time to metastasis as well as 10-year Ove...
Open Access DOI:10.23937/2643-4059/1710036
Can Deep Brain Stimulation Be a Promising Treatment for Treatment-Resistant Depression?
Nazanin Amirani, MSc* and Ijeuma Nwachuku, PhD
Article Type: Review Article | First Published: February 18, 2023
In recent decades, despite remarkable advances in antidepressant medication, psychotherapy, and electrical stimulation, between 20%-30% of patients suffering from major depressive disorder remain untreated or are at a high risk of relapse. Deep brain stimulation (DBS) is a recently invented modality that has been under investigation since 2005, however, the US Food and Drug Administration (FDA) has not yet approved it as a final line in treating severe depression....
Open Access DOI:10.23937/2643-4059/1710035
Use of Warmth for the Treatment of Blues
Adhishri Yadav
Article Type: Review Article | First Published: February 16, 2023
Current rise in depression leading to high disease burden and economic strain demands more research and proposals towards effective and practical treatment protocols for Major Depressive Disorders. Heat therapies have gained its reputation as an effective alternative treatment from various psychiatric, medical, and cultural studies which is significantly relevant in view of consideration of the gap between provision and adherence for treatment and ineffectiveness of current treatment choices....
Open Access DOI:10.23937/2378-3397/1410148
A General Surgeon’s Guide to Post COVID-19 Multi-System Inflammatory Syndrome (MIS)
Ali Baker, BMBS, Howard Tang, MD, Russel Krawitz, MBCHB, FRACS, James Molton, MD, RACP, Adrian Tramontana, MD, RACP and Justin Yeung, MD, FRACS
Article Type: Research Article | First Published: March 03, 2023
Presented is a literature review on Multisystem inflammatory syndrome (MIS) which can occur following recovery from the initial phase of COVID-19 infection. Because of the predominance of gastro-intestinal symptoms MIS can mimic an acute abdomen. We present a series of two cases of MIS-A occurring over a six month period at a single institution. The rationale for this work was to highlight MIS-A as an emerging syndrome and reduce associated morbidity and mortality....
Open Access DOI:10.23937/2378-3397/1410147
Nasal and Cheek Reconstruction with Flaps
Carlos Santiago Ruggeri, Elian García Pita, Gabriel Rondón Gonzalez, Ana Clara Ragoni and Inés Fagalde
Article Type: Original Article | First Published: December 12, 2022
Reconstruction of the nose and cheek after oncologic resections or severe infections resulting in facial necrosis is challenging. Sometimes different facial regions must be repaired, and different flaps must be used to achieve a good functional and aesthetic result. Local flaps and in cases of extensive defects, regional flaps are an excellent option for the reconstruction....
Open Access DOI:10.23937/2377-9004/1410232
A Case Report on Successful Management of Complete Placenta Previa with Internal Iliac Artery Ligation
Nalini Thiruvengadam and Kavitha Gautham
Article Type: Case Report | First Published: February 10, 2023
Placenta previa is a complex and extremely challenging scenario as it may result in serious life-threatening conditions like postpartum hemorrhage (PPH). In this case report we present a 32-year-old Primi with 37 weeks of gestational age who approached a multispeciality private hospital at Chennai with complaints of bleeding per vagina around 32 weeks. The Ultrasonogram finding revealed type- 3 placenta previa posterior and the patient was hospitalized. The concise steps taken in the managemen...
Open Access DOI:10.23937/2377-9004/1410231
Labial Agglutination in a Reproductive Age Woman
Annie Ruth B Dayu, MD and Ma. Isidora Margarita Yap-Garcia, MD
Article Type: Case Report | First Published: November 05, 2022
A 25-year-old nulligravid was consulted due to inability to have sexual intercourse accompanied by chronic urinary hesitancy, dribbling, and dysmenorrhea. On gynecologic pelvic examination, she presented with complete, adult- onset fusion of the labia minora. This paper describes a stepwise management of a reproductive-age woman with complete labial fusion. Treatment goals include etiological determination, anatomic correction, restoration of normal sexual function, improvement of genitourinary...
Open Access DOI:10.23937/2572-4193.1510132
Pasteurella multocida Submandibular Gland Abscess and Sepsis: Case Report and Literature Review
Antonio Mastroianni, MD, Sonia Greco, MD, Valeria Vangeli, MD, Maria Vittoria Mauro, MD, Daniela Perugini, MD, Francesca Greco, MD and Roberto Manfredi, MD
Article Type: Case Report | First Published: February 23, 2023
Pasteurella multocida, a gram-negative coccobacillus, part of the normal oral flora of many domestic and wild mammals, has been described a widespread veterinary pathogen and has the potential to cause zoonotic infections in humans resulting from injuries caused by household or wild pets. Skin and soft tissue infections following a cat or dog bite are the more common manifestations of human infection. Salivary gland infections are somewhat common and viral infections, such as mumps, and bacteria...
Open Access DOI:10.23937/2474-3658/1510290
Pregnancy Outcomes during the COVID-19 Pandemic: A Study Based on a Tertiary Care Hospital in Sri Lanka
Thumula Ratnayake, Dompege Don Dananjaya Srimal Bandara and Mohottalalage Sunethra Sandhya Kumari Bandara
Article Type: Original Article | First Published: January 31, 2023
The COVID-19 pandemic response affected maternal and neonatal health services worldwide. This study aimed to explore the impact of the pandemic on pregnancy outcomes, such as monthly stillbirth rates, percentage of monthly lower segment cesarean sections (LSCS), percentage of monthly preterm births, and percentage of monthly neonatal unit admissions at a tertiary care hospital in Sri Lanka. The study was conducted as a retrospective medical record-based study and included a total of 28,292 deliv...