Open Access DOI:10.23937/2474-3658/1510294
Increasing Cases of Chronic Hepatitis B Virus Infection in West Africa: Is Combination Therapy and Immunomodulators the Best Cure?
Godfred Yawson Scott, Noble Princess Chinelo, Zakariya'u Dauda and Azubuike Immanuel
Article Type: Perspective | First Published: February 22, 2023
West Africa has a high endemicity of chronic hepatitis B, which causes liver cancer, cirrhosis, liver failure, and chronic liver disease, all of which put a severe strain on the region's already crippled healthcare system. This disease kills nearly 200,000 people in West Africa each year. As a result, finding a cure is critical. Several scientists have developed potential treatments for this disease over the years. However, the majority of them have failed....
Open Access DOI:10.23937/2474-3658/1510293
Severe Community - Acquired Achromobacter denitrificans Cellulitis
Antonio Mastroianni, MD, Sonia Greco, MD, Valeria Vangeli, MD, Maria Vittoria Mauro, MD, Francesca Greco, MD, Filippo Urso, MD and Roberto Manfredi, MD
Article Type: Case Report | First Published: February 18, 2023
Achromobacter is a genus of non-fermenting gram-negative bacteria, mainly isolated from the respiratory tract of people with cystic fibrosis, but recognized as the causal agent of different types of infections, especially in individuals and with chronic diseases and immune deficiency. Skin infections are very rare and not easy to manage also due to the intrinsic resistance to various antibiotics empirically used in the treatment of skin infections. In this short report, we intend to describe a r...
Open Access DOI:10.23937/2474-3658/1510292
Circulation of SARS-CoV-2 Omicron Variant (B1.1.529) in the General Population of Western Burkina Faso, West Africa
Yacouba Sawadogo, Jessica Julie Chantal Samba, Raïssa Muriel de Souza, Noutin Fernand Michodigni, Arsène Zongo, Amariane Marie Madeleine Koné, Isidore Traoré, Odilon Kaboré, Cheick Ahmed Ouattara, Natasha Dubois Cauwelaert, Essia Belarbi, Eric D'Ortenzio, Dramane Kania and Abdoul-Salam Ouedraogo
Article Type: Original Article | First Published: January 31, 2023
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant was responsible of an increase of the COVID-19 incidence worldwide. This study aimed to investigate the circulation of SARS-CoV-2 Omicron variant (B1.1.529) in the general population in Burkina Faso and provide better preventive strategies. This was a descriptive cross-sectional study conducted from November 2021 to November 2022. All individuals with PCR-positive results were tested with the DI SARS-CoV-2 MOC/I Mul...
Open Access DOI:10.23937/2474-3658/1510291
Epidemiological and Diagnostic Aspects of Cholera Epidemics in Eastern Democratic Republic of Congo between January 2011 and June 2022
Patrick AYONGA NDEBA, Bruce WEMBULUA SHINGA, Fatimata WONE, Alain- Bruno BARDIGUYO, Lassina DIALLO, Jackson BYAMUNGU MPINGA, Henriette MULASI KITUTU, Raphael KABANGWA KAKONGO SENGA, Viviane Marie-Pierre CISSE and Roger Clément Kouly TINE
Article Type: Original Article | First Published: January 31, 2023
Nearly 4 million cases of cholera are reported each year worldwide, including 189,000 (5 to 14%) in the Democratic Republic of Congo (DRC). The eastern provinces, known as “hot spots”, report more than half of these cases. Describe the epidemiological and diagnostic aspects of cholera in eastern DRC....
Open Access DOI:10.23937/2378-3664.1410039
Possible Effect of Nano Characterization of COVID-19 on Infection and Causing Disease
Wang Shenguo
Article Type: Original Article | First Published: February 23, 2023
In this article, based on analysis of chemical composition and morphology structure of the New Coronavirus Disease-19 (COVID-19), that the COVID-19 belongs a kind protein nanoparticle virus with spherical complex structure has been explained. So, the COVID-19 possesses characteristics of ultra-small size, large specific surface, both hydrophilicity and lipophilicity, that just as all of the nanoparticles. It leads to the COVID-19 producing fast spread speed, large spread range and strong infecti...
Open Access DOI:10.23937/2474-1353/1510145
The Relationship between Mothers’ Breastfeeding Anxiety and Fear of COVID-19
Zümrüt Bilgin, PhD, RN, Duygu Tatar, MSc, Selma Berda Şahin, MSc, Tuğba Topcu, MSc, Beyza Aktürk, MSc and İrem Zülal Topçuoğlu, MSc
Article Type: Original Article | First Published: February 01, 2023
This study aimed to determine the relationship between breastfeeding anxiety of mothers and fear of COVID-19. The research was designed as a descriptive study. This research was conducted in a maternity hospital in Istanbul between 03 May and 31 August 2021. The study sample consisted of 348 primiparous and multiparous volunteer mothers who had vaginal and cesarean section delivery methods. The research data were collected using the “Descriptive Information Form” and “The Fear of Coronavir...
Open Access DOI:10.23937/2572-3286.1510082
Renal Angina Index and Neutrophil-to-Lymphocyte Ratio: Predictive of Acute Kidney Injury in PICU
Peerapohn Pongsupamongkol, MD, Rujipat Samransamruajkit, MD and Tawatchai Deekajorndech, MD
Article Type: Original Article | First Published: January 23, 2023
Acute kidney injury (AKI) is associated with increased mortality in pediatric intensive care unit (PICU) patients. Early detection of AKI helps clinicians to manage promptly. Renal angina index (RAI) is established from changes in serum creatinine and condition of patients. Neutrophil-to-lymphocyte ratio (NLR) is calculated from a complete blood count (CBC). There are very few studies on the application of RAI and NLR in PICU. This study aims to evaluate the efficacy of RAI and NLR as AKI biomar...
Open Access DOI:10.23937/2378-3664.1410038
Study of Mesenchymal Stem Cell in Combination with Self-Assembled Functional Nanopeptide Gel to Promote Angiogenesis
Zhanao Liu, Ailing Tian, Xin Yi, Nianfeng Sun and Yong Di
Article Type: Research Article | First Published: January 15, 2023
To investigate the transplantation of a functionalized self-assembling nanopeptide hydrogel loaded with adipose-derived mesenchymal stem cells (AD-MSCs) into a rabbit hindlimb ischemia model and to evaluate its effect in promoting vascular regeneration in ischemic tissues. Functionalized self-assembling nanopeptide hydrogels were synthesized, and the physical and chemical properties of the hydrogels were observed by electron microscopy. Primary AD-MSCs were isolated, cultured, immunophenotyped, ...
Open Access DOI:10.23937/2643-4059/1710033
Use of Objective Rating Scales for Generalized Anxiety by Psychiatry Specialists in Pediatric Populations
Brittany Finocchio, PharmD, BCPP and Wanda Hilliard, DNP, MBA, APRN, PMHNP-BC
Article Type: Research Article | First Published: January 15, 2023
In 2021, leading pediatric healthcare organizations declared a national state of emergency in children’s mental health in America. Anxiety disorders are among the most common mental health conditions affecting pediatric populations. The Diagnostic and Statistical Manual of Mental Disorders, 5th edition, recommends objective measurement of pediatric anxiety for evaluation of symptomatology and treatment response. The objective of this review was to summarize recommendations and resources for me...