Open Access DOI:10.23937/2572-4037.1510005

Data Mining Methods in Psychiatry

Handan Ankarali

Article Type: Opinion | First Published: February 27, 2015

As known, univariate statistical models have strong assumptions such as normality and homogeneity of variance. When the assumptions are valid, univariate models have powerful results. Variables having certain properties evaluate by univariate model. Univariate models are made incorrect prediction generally, because these models not include the relationships between variables....

 Open Access DOI:10.23937/2469-5726/1510006

Connective Tissue Disease-Associated Interstitial Lung Disease

Marcelo Fernandez Casares

Article Type: Editorial | First Published: March 02, 2015

Interstitial Lung Diseases (ILDs) also known as Diffuse Parenchymal Lung Disease (DPLD), include a large group of lung diseases characterized by various patterns of inflammation and fibrosis on high-resolution CT and in lung biopsy....

 Open Access DOI:10.23937/2469-5726/1510005

Suppression of Experimental Arthritis through AMP-Activated Protein Kinase Activation and Autophagy Modulation

Huimin Yan, Hui-Fang Zhou, Ying Hu and Christine T.N. Pham

Article Type: Research Article | First Published: February 28, 2015

Autophagy plays a central role in various disease processes. However, its contribution to inflammatory arthritides such as rheumatoid arthritis (RA) is unclear. We observed that autophagy is engaged in the K/BxN serum transfer model of RA but autophagic flux is severely impaired. Metformin is an anti-diabetic drug that has been shown to stimulate autophagy. Induction of autophagic flux, through metformin-mediated AMP-activated protein kinase (AMPK) activation and interruption of mammalian target...

 Open Access DOI:10.23937/2572-3278.1510003

Insulin Resistance and Diet Care

Jun Kobayashi

Article Type: Editorial | First Published: March 02, 2015

During human evolution, insulin signaling developed to ensure normal homeostasis to redirect nutrients to pivotal organs under critical conditions such as starvation, infection, and trauma. However, in the modern era, insulin signaling is often counter productive due to the current obesogenic environment, resulting in insulin resistance....

 Open Access DOI:10.23937/2572-4045.1510004

Simultaneous Liver Kidney Transplantation

Kirk B. Russ and Ashwani K. Singal

Article Type: Editorial | First Published: March 02, 2015

Since the introduction of model for end-stage liver disease (MELD) score in 2002 for listing patients for liver transplantation, frequency and proportion of simultaneous liver kidney (SLK) transplantation has increased by over 300%. This is mainly due to incorporation of renal function and serum creatinine as one of the major factors in determining the MELD score. ...

 Open Access DOI:10.23937/2469-5742/1510002

Male Sling: A Decade Later

Ajay Singla

Article Type: Editorial | First Published: February 28, 2015

Urethral compression provided by a male sling is not a new concept. A variety of urethral compression procedures have been applied in an attempt to control urinary incontinence over the years. Most notable were the Kaufman procedures which used silicone gel prosthesis to compress the ventral urethra....

 Open Access DOI:10.23937/2572-4045.1510003

A Letter of Reminder to all Nephrologists and Surgeons: The importance of Sticking to KDOQI Guidelines for Selection and Placement of Hemodialysis Access

Ethem Unal

Article Type: Editorial | First Published: February 26, 2015

Kidney Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guidelines for Vascular Access have defied the access related care for patients with end-stage renal disease [1]. However, the standard of care across the world has fallen short of the KDOQI targets. One potential explanation for these shortcomings is the lack of compelling evidence in the literature to support the recommendations. ...

 Open Access DOI:10.23937/2572-4045.1510002

Stem Cell Transplantation (SCT) to Treat Severe Refractory Multiple Sclerosis (MS)

Athanasia Mouzaki

Article Type: Editorial | First Published: February 23, 2015

Multiple Sclerosis usually affects young adults aged between 20 to 40 years, although it can begin earlier or later in life. Women are affected almost twice as often as men. Symptoms include sensory disturbances in the limbs, optic nerve dysfunction, pyramidal tract dysfunction, bladder or bowel dysfunction, sexual dysfunction, ataxia and diplopia. ...

 Open Access DOI:10.23937/2469-5734/1510003

Dental Implant Therapy in Patients Affected by Oral Mucosal Diseases

Sertan Ergun

Article Type: Short Communication | First Published: March 02, 2015

Dental implants are increasingly used for the treatment of complete and /or partial eduntulism. Related literature search revealed that dental implants are associated with high survival rates of close 92-98% after 10 years. The success of implant therapy is very close associated with the appropriate patient selection....

 Open Access DOI:10.23937/2469-5734/1510002

Minimally Invasive Endodontics: A Fancy Trend or A Clear Road for the Future?

Damiano Pasqualini

Article Type: Editorial | First Published: February 28, 2015

Endoscopic surgery began to progressively replace a more invasive open surgery, with minimal or no damage to surrounding healthy tisssues, and a more favorable post-operative period. Since then the concept has been influencing many other medical disciplines, including dentistry and consequently endodontics....