Open Access DOI:10.23937/2572-4215.1510033
An Atypical Presentation of Guillain-Barre Syndrome with Descending Paralysis: A Case Report
Sergio Mosquera Limas, Jesse Blount, Rebecca Riekki and Suhana Singh
Article Type: CASE REPORT | First Published: June 21, 2025
The patient had an atypical presentation of Guillain- Barre syndrome (GBS) with descending muscle weakness and paralysis that started at the upper extremities and progressed to the lower extremities in contrast to a typical ascending infection that usually starts at the lower extremities. Hyporeflexia of deep tendon reflexes of the affected extremities was also present....
Open Access DOI:10.23937/2469-570X/1410081
Identification of Colorectal Adenocarcinoma Key Genes to Be Validated as Potential Prognosis Biomarkers
Elham Omer Mahgoub, Pooja Prakash Mankar, Amit kumar, Syed Asif Husain Naqv and Bharti Mittal
Article Type: RESEARCH ARTICLE | First Published: May 27, 2025
Advanced bioinformatics methods were used to gain a thorough understanding of the genetic landscape of colorectal cancer. The transcriptome RNA-seq raw data were obtained from PRJEB24758 in the European Nucleotide Archive (ENA) database. Then, the Sequence Read Archive (SRA) runs a selection to download the sequences database. The transcriptomic RNA released data is analyzed by the bioinformatics tool, which also uses online analytic tools to help visualize the results and identify key genes tha...
Open Access DOI:10.23937/2377-9004267
Ruptured Ovarian Ectopic Pregnancy a Case Report from Leku General Hospital, Ethiopia
Asfaw Kibret
Article Type: CASE REPORT | First Published: June 06, 2025
An ovarian ectopic pregnancy is rare occurrence and it is implantation of throphoblastic tissue in or on the ovarian tissue. Most of the time delayed for diagnosis due to its resemblance on ultrasound as hemorrhagic ovarian cyst, hemorrhagic corpus luteum cyst or endometrioma. Usually it ruptures in the first trimester of pregnancy and due to its rich blood supply it is deadly hemorrhagic once it is ruptured....
Open Access DOI:10.23937/2378-3516/1410195
Sotatercept in the Treatment of Pulmonary Arterial Hypertension: A Comprehensive Narrative Review of Mechanism, Efficacy, and Future Directions
Niroshan Ranjan, MD, Ahmed Ahmed, MD, Jordana Woods, MD, Ramaneshwar Selvaraj, MBBS, Mihir Patel, DO, Yaman Dalati, DO, Vidushan Sabanathan and Thanujan Thangadurai, MD
Article Type: Narrative Review | First Published: May 17, 2025
Pulmonary arterial hypertension (PAH) is a progressive vascular remodeling disease with elevated pulmonary vascular resistance that is lethal. While therapeutic progress was recently made with endothelin, nitric oxide, and prostacyclin pathway-based therapy for the treatment of PAH, the disease is currently incurable with a high cost of morbidity and mortality. Sotatercept, a new activin receptor IIA-Fc fusion protein, may prove to be a gamechanger as a therapeutic agent for the treatment of PAH...
Open Access DOI:10.23937/2469-5696/1410099
K₂EDTA vs K₃EDTA Stability in Yemen: Sysmex KX-21N Performance in Tropical Lab
Naif Taleb Ali
Article Type: Case Report | First Published: May 12, 2025
Haematological diagnostics occupy a central role in clinical decision-making, with the complete blood count (CBC) serving as a fundamental test for conditions ranging from anaemia to infection. However, the accuracy of CBC results is profoundly influenced by preanalytical variables, particularly the choice of anticoagulant and sample processing timelines (Lippi, 2017)....
Open Access DOI:10.23937/2572-3235.1510134
Ultrasound-Guided Biopsy of Breast Masses in Interventional Radiology Units in Kinshasa
Frederick Tshibasu Tshienda, Tasnime Hamdeni, Najat cherif Idrissi El Ganouni, Jean Mukaya Tshibola, Michel Lelo Tshikwela, Jean Marie Kayembe Ntumba and Jean-Marie Mbuyi Muamba
Article Type: Original Research Article | First Published: May 16, 2025
This was a retrospective, descriptive, multicenter study conducted over a 6-year period from June 2018 to June 2024 and compiled at the university clinics of Kinshasa. Any patient who underwent percutaneous echo-guided biopsy sampling using the multiple-pass technique without co-axial was included. Biopsy specimens were taken using 14 to 17 G tru-cut needles. Data analysis was performed using SPSS version 2.2 software, which enabled us to collect 107 patients....
Open Access DOI:10.23937/2643-4474/1710170
Mild Traumatic Brain Injury and Subacute Subdural Hematoma: Intraoperative Discovery of a Hemorrhagic Arachnoid Cyst
Djalma de Campos Goncalves
Article Type: Case Report | First Published: May 16, 2025
Arachnoid cysts are benign congenital malformations typically located within the cerebrospinal fluid spaces of the brain. They are often asymptomatic and discovered incidentally. However, complications such as hemorrhage can render them clinically significant, especially following minor trauma. We present the case of a 19-year-old male who developed a progressive headache after mild head trauma. Neuroimaging revealed a right frontoparietal subacute subdural hematoma with significant midline shif...
Open Access DOI:10.23937/2469-5742/1510098
Penile Strangulation: A Case Report on Emergency Management in Resource-Limited
Mounir El Idrissi El Jouhari, Bjane O, Bouchareb M, Kabirou A, Moataz A, Dakir M, Debbagh A and Aboutaieb R
Article Type: Case Report | First Published: May 14, 2025
Penile strangulation is a rare but potentially serious urological emergency requiring prompt intervention to prevent severe complications. We report the case of a 30-year-old man with a history of psychiatric disorders who presented to the emergency department with progressive penile swelling and pain after placing a wedding ring around the coronal sulcus. Attempts at removal using lubrication had failed, leading to worsening edema....